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FECB - Fe(3+) dicitrate-binding periplasmic protein
UniProt: P15028 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10287
Length: 300 (274)
Sequences: 5934
Seq/Len: 21.66
FECB
Paralog alert: 0.75 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: BTUF FECB FEPB FHUD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
144_G 153_M 5.055 1.00
228_N 256_T 4.884 1.00
149_K 152_E 3.618 1.00
141_A 154_Q 3.463 1.00
145_E 150_K 3.445 1.00
256_T 260_K 3.291 1.00
42_V 48_A 3.037 1.00
154_Q 158_E 2.864 1.00
200_L 205_L 2.836 1.00
158_E 162_E 2.77 1.00
152_E 155_A 2.638 1.00
94_A 97_A 2.505 1.00
25_Q 30_T 2.495 1.00
137_L 161_K 2.445 1.00
165_A 169_S 2.429 1.00
41_V 95_I 2.394 1.00
39_R 59_I 2.379 1.00
176_R 206_N 2.362 1.00
163_R 281_E 2.321 1.00
26_D 31_F 2.313 1.00
161_K 165_A 2.278 1.00
40_I 147_V 2.202 1.00
51_L 147_V 2.2 1.00
197_G 201_A 2.136 1.00
223_Q 226_A 2.136 1.00
23_T 30_T 2.1 1.00
116_A 119_Q 2.075 1.00
141_A 157_L 2.072 1.00
230_A 256_T 2.065 1.00
155_A 159_Q 2.026 1.00
134_A 161_K 1.97 1.00
247_Q 261_Q 1.969 1.00
138_Q 154_Q 1.951 1.00
56_V 149_K 1.923 1.00
60_G 98_L 1.922 1.00
56_V 147_V 1.903 1.00
23_T 32_T 1.89 1.00
104_I 143_I 1.863 1.00
162_E 166_Q 1.844 1.00
132_T 135_E 1.842 1.00
166_Q 170_Q 1.813 1.00
114_Y 118_Q 1.794 1.00
90_P 95_I 1.706 1.00
255_L 258_A 1.661 1.00
93_E 222_E 1.648 1.00
165_A 168_A 1.643 1.00
41_V 98_L 1.642 1.00
26_D 29_G 1.599 1.00
115_I 119_Q 1.591 1.00
231_W 264_A 1.59 1.00
37_P 101_D 1.571 1.00
96_A 120_I 1.557 1.00
163_R 285_A 1.549 1.00
41_V 60_G 1.547 1.00
54_V 149_K 1.543 1.00
124_L 146_M 1.527 1.00
252_W 258_A 1.51 1.00
135_E 138_Q 1.499 1.00
42_V 51_L 1.496 1.00
231_W 262_Q 1.496 1.00
38_Q 101_D 1.49 1.00
159_Q 163_R 1.488 1.00
22_A 145_E 1.468 1.00
151_R 155_A 1.456 1.00
141_A 161_K 1.445 1.00
286_D 289_K 1.441 1.00
150_K 154_Q 1.436 1.00
244_K 248_Q 1.428 1.00
256_T 259_Q 1.418 1.00
223_Q 227_V 1.382 0.99
115_I 118_Q 1.38 0.99
243_V 247_Q 1.365 0.99
82_Q 94_A 1.364 0.99
157_L 161_K 1.357 0.99
151_R 154_Q 1.344 0.99
254_M 259_Q 1.343 0.99
58_P 81_W 1.327 0.99
158_E 161_K 1.325 0.99
244_K 247_Q 1.316 0.99
50_A 140_A 1.316 0.99
91_S 94_A 1.312 0.99
177_V 205_L 1.308 0.99
111_A 115_I 1.301 0.99
102_L 124_L 1.294 0.99
208_P 227_V 1.292 0.99
176_R 230_A 1.275 0.99
159_Q 162_E 1.266 0.99
152_E 156_R 1.266 0.99
53_A 156_R 1.228 0.98
103_I 120_I 1.227 0.98
169_S 172_P 1.221 0.98
209_A 227_V 1.218 0.98
33_L 36_T 1.201 0.98
142_I 146_M 1.201 0.98
221_L 249_D 1.196 0.98
39_R 99_K 1.196 0.98
154_Q 157_L 1.174 0.98
232_L 257_A 1.168 0.97
105_A 125_L 1.167 0.97
252_W 255_L 1.152 0.97
40_I 102_L 1.146 0.97
211_M 227_V 1.143 0.97
178_A 224_L 1.132 0.97
51_L 104_I 1.114 0.96
33_L 122_P 1.11 0.96
59_I 98_L 1.107 0.96
162_E 165_A 1.096 0.96
76_A 79_K 1.095 0.96
47_F 104_I 1.095 0.96
166_Q 169_S 1.091 0.96
35_K 38_Q 1.091 0.96
20_F 148_G 1.085 0.96
174_G 206_N 1.072 0.95
175_T 231_W 1.064 0.95
164_M 202_S 1.059 0.95
21_A 35_K 1.059 0.95
284_A 288_V 1.051 0.94
156_R 159_Q 1.05 0.94
33_L 37_P 1.048 0.94
52_A 78_L 1.041 0.94
163_R 167_W 1.039 0.94
41_V 59_I 1.038 0.94
26_D 114_Y 1.037 0.94
225_L 255_L 1.031 0.94
54_V 156_R 1.03 0.94
285_A 289_K 1.02 0.93
142_I 145_E 1.018 0.93
281_E 285_A 1.009 0.93
21_A 32_T 1.009 0.93
177_V 200_L 1.007 0.93
168_A 202_S 1.007 0.93
26_D 30_T 1.006 0.93
138_Q 141_A 1.006 0.93
51_L 56_V 1.003 0.93
60_G 85_G 1.003 0.93
103_I 121_A 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lhsA10.941000.222Contact Map0.72
3mwfA10.921000.252Contact Map0.769
3tnyA10.94331000.253Contact Map0.739
3tefA10.92671000.263Contact Map0.742
3tlkA30.97331000.273Contact Map0.711
3zkwA20.91671000.274Contact Map0.788
4mlzA20.94671000.275Contact Map0.685
4hn9A20.961000.277Contact Map0.78
4jccA10.90671000.285Contact Map0.643
4mdyA10.93331000.286Contact Map0.7
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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