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OPENSEQ.org
INSL3 - Putative transposase InsL for insertion sequence element IS186C
UniProt: P0CF93 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG60039
Length: 370 (330)
Sequences: 464
Seq/Len: 1.41
INSL3
Paralog alert: 0.42 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: INSG INSL1 INSL2 INSL3
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
116_G 154_E 2.766 1.00
128_E 150_S 2.613 1.00
329_A 334_L 2.488 1.00
189_D 290_S 2.408 1.00
132_H 148_T 2.054 0.98
168_I 304_C 1.956 0.97
328_R 338_W 1.848 0.96
291_L 296_Y 1.834 0.96
222_K 225_E 1.775 0.95
221_G 224_G 1.762 0.94
225_E 228_V 1.719 0.93
123_G 130_R 1.713 0.93
162_T 165_E 1.705 0.93
76_A 79_K 1.67 0.92
75_V 79_K 1.613 0.90
194_V 198_G 1.573 0.88
113_L 137_P 1.552 0.87
190_Y 244_A 1.551 0.87
73_S 76_A 1.536 0.87
92_A 343_L 1.526 0.86
190_Y 290_S 1.506 0.85
329_A 338_W 1.505 0.85
311_I 315_F 1.494 0.85
329_A 335_A 1.48 0.84
25_A 301_V 1.476 0.84
183_L 188_A 1.476 0.84
50_Y 329_A 1.472 0.83
171_R 192_V 1.448 0.82
130_R 153_A 1.43 0.81
43_L 173_F 1.429 0.81
37_I 79_K 1.421 0.80
317_R 350_D 1.421 0.80
132_H 173_F 1.419 0.80
177_P 198_G 1.384 0.78
312_E 319_K 1.378 0.77
60_V 88_F 1.368 0.77
249_V 287_L 1.352 0.76
113_L 128_E 1.344 0.75
27_N 90_I 1.342 0.75
332_P 336_K 1.339 0.75
112_R 165_E 1.337 0.74
221_G 226_T 1.335 0.74
316_K 320_S 1.328 0.74
316_K 322_L 1.308 0.72
37_I 56_S 1.307 0.72
316_K 321_L 1.306 0.72
135_Y 340_F 1.305 0.72
129_W 345_A 1.301 0.71
331_E 340_F 1.289 0.70
37_I 76_A 1.285 0.70
301_V 315_F 1.283 0.70
316_K 319_K 1.28 0.70
337_A 341_A 1.278 0.70
305_Y 308_R 1.256 0.68
305_Y 309_W 1.256 0.68
192_V 288_L 1.253 0.67
77_L 95_T 1.246 0.67
249_V 302_A 1.242 0.66
330_K 338_W 1.233 0.66
46_L 86_D 1.23 0.65
321_L 347_F 1.226 0.65
178_E 339_I 1.224 0.65
25_A 134_G 1.216 0.64
169_A 192_V 1.216 0.64
317_R 335_A 1.214 0.64
121_A 314_A 1.213 0.64
37_I 45_R 1.205 0.63
313_L 316_K 1.2 0.62
56_S 301_V 1.194 0.62
118_A 130_R 1.187 0.61
92_A 346_A 1.183 0.61
130_R 150_S 1.181 0.61
130_R 290_S 1.178 0.60
30_A 87_W 1.178 0.60
22_D 26_R 1.177 0.60
39_D 83_N 1.176 0.60
210_D 222_K 1.168 0.59
197_R 288_L 1.167 0.59
221_G 230_I 1.164 0.59
136_D 195_H 1.161 0.59
89_G 93_A 1.157 0.58
13_A 131_L 1.154 0.58
317_R 346_A 1.153 0.58
109_K 166_I 1.153 0.58
64_A 139_T 1.153 0.58
136_D 171_R 1.15 0.58
307_L 310_Q 1.147 0.57
104_G 117_T 1.147 0.57
173_F 301_V 1.146 0.57
166_I 291_L 1.139 0.56
271_G 289_T 1.136 0.56
123_G 126_S 1.136 0.56
328_R 341_A 1.136 0.56
327_L 338_W 1.128 0.55
117_T 123_G 1.127 0.55
6_D 10_A 1.126 0.55
34_R 247_I 1.126 0.55
145_F 222_K 1.12 0.55
208_R 247_I 1.12 0.55
176_R 347_F 1.116 0.54
310_Q 313_L 1.116 0.54
273_V 282_A 1.116 0.54
102_V 161_Q 1.11 0.54
100_A 311_I 1.109 0.53
172_G 285_V 1.106 0.53
57_L 119_I 1.105 0.53
72_L 76_A 1.102 0.53
76_A 80_R 1.1 0.53
113_L 240_A 1.098 0.52
327_L 334_L 1.097 0.52
21_L 24_S 1.095 0.52
317_R 338_W 1.095 0.52
106_T 127_A 1.094 0.52
334_L 342_N 1.091 0.52
91_L 344_L 1.09 0.51
50_Y 341_A 1.089 0.51
20_E 43_L 1.089 0.51
111_L 304_C 1.085 0.51
211_M 247_I 1.084 0.51
43_L 60_V 1.083 0.51
284_H 331_E 1.08 0.50
221_G 228_V 1.078 0.50
139_T 151_R 1.074 0.50
250_S 271_G 1.073 0.50
182_S 186_G 1.068 0.49
180_I 192_V 1.067 0.49
290_S 327_L 1.066 0.49
272_R 282_A 1.063 0.49
96_L 347_F 1.061 0.49
136_D 339_I 1.061 0.49
29_G 297_S 1.06 0.48
147_L 168_I 1.057 0.48
93_A 144_D 1.054 0.48
218_L 247_I 1.053 0.48
57_L 77_L 1.053 0.48
81_L 338_W 1.053 0.48
75_V 126_S 1.05 0.47
35_R 116_G 1.045 0.47
168_I 192_V 1.044 0.47
97_A 227_T 1.042 0.47
75_V 78_L 1.039 0.46
91_L 343_L 1.038 0.46
62_A 339_I 1.038 0.46
172_G 195_H 1.037 0.46
252_P 311_I 1.033 0.46
333_E 338_W 1.031 0.46
218_L 221_G 1.031 0.46
153_A 171_R 1.03 0.45
171_R 193_R 1.027 0.45
314_A 322_L 1.025 0.45
308_R 312_E 1.025 0.45
309_W 312_E 1.025 0.45
210_D 219_D 1.025 0.45
85_A 336_K 1.024 0.45
337_A 347_F 1.024 0.45
165_E 183_L 1.02 0.44
17_K 173_F 1.016 0.44
304_C 322_L 1.015 0.44
94_Q 345_A 1.015 0.44
117_T 130_R 1.015 0.44
121_A 316_K 1.014 0.44
181_R 185_F 1.013 0.44
317_R 322_L 1.008 0.43
173_F 304_C 1.008 0.43
101_A 113_L 1.006 0.43
80_R 108_G 1.004 0.43
328_R 337_A 1.004 0.43
44_L 141_Q 1.002 0.43
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1musA10.840599.90.711Contact Map0.356
2fm9A10.216.80.967Contact Map0.289
3atrA10.24054.40.975Contact Map0.275
2opoA40.22433.80.976Contact Map0.419
2fm8C10.26493.10.977Contact Map0.213
2kycA10.27032.50.978Contact Map0.138
4iikA10.16222.40.978Contact Map0.525
2g7rA20.19462.30.978Contact Map0.243
1pdnC10.22162.30.978Contact Map0.525
2ga1A20.25412.30.978Contact Map0.278
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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