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OPENSEQ.org
SPR - Probable endopeptidase Spr
UniProt: P0AFV4 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14076
Length: 188 (180)
Sequences: 207
Seq/Len: 1.15
SPR
Paralog alert: 0.01 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: NLPC SPR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
121_G 182_R 2.241 0.99
110_L 184_V 2.104 0.98
77_W 92_I 1.983 0.96
76_D 89_K 1.937 0.96
134_L 146_V 1.853 0.94
26_A 184_V 1.804 0.93
167_S 171_E 1.782 0.92
24_L 27_C 1.757 0.92
113_S 171_E 1.694 0.90
121_G 183_R 1.642 0.88
124_V 129_L 1.624 0.87
126_R 129_L 1.593 0.85
98_V 146_V 1.511 0.81
82_Y 158_A 1.493 0.80
178_Y 181_A 1.481 0.79
77_W 149_Y 1.433 0.76
92_I 96_G 1.428 0.76
74_Y 156_V 1.427 0.75
92_I 100_R 1.419 0.75
102_F 181_A 1.4 0.73
129_L 181_A 1.382 0.72
99_Q 111_P 1.322 0.67
117_Q 158_A 1.321 0.67
70_I 77_W 1.311 0.66
77_W 106_F 1.309 0.66
159_S 167_S 1.289 0.64
149_Y 153_N 1.282 0.64
21_A 83_R 1.277 0.63
86_G 91_G 1.269 0.63
96_G 165_I 1.266 0.62
126_R 141_S 1.263 0.62
169_M 179_N 1.259 0.62
151_G 178_Y 1.258 0.62
148_I 151_G 1.255 0.61
114_T 149_Y 1.255 0.61
151_G 182_R 1.254 0.61
168_S 171_E 1.244 0.60
89_K 163_G 1.22 0.58
97_F 164_V 1.217 0.58
84_L 97_F 1.216 0.58
101_T 148_I 1.216 0.58
83_R 126_R 1.214 0.58
123_S 128_N 1.214 0.58
14_G 33_A 1.206 0.57
129_L 149_Y 1.202 0.56
159_S 165_I 1.196 0.56
26_A 160_T 1.183 0.55
136_L 146_V 1.168 0.53
35_N 42_A 1.153 0.52
29_A 117_Q 1.152 0.52
143_G 179_N 1.15 0.51
146_V 167_S 1.148 0.51
134_L 144_R 1.145 0.51
17_A 21_A 1.145 0.51
70_I 106_F 1.138 0.50
129_L 153_N 1.133 0.50
8_L 13_R 1.125 0.49
87_S 97_F 1.125 0.49
110_L 117_Q 1.125 0.49
26_A 156_V 1.12 0.49
26_A 31_N 1.118 0.48
111_P 116_E 1.112 0.48
113_S 152_N 1.11 0.48
120_M 124_V 1.108 0.47
98_V 148_I 1.108 0.47
111_P 121_G 1.099 0.46
89_K 165_I 1.087 0.45
129_L 174_W 1.086 0.45
12_L 21_A 1.083 0.45
156_V 184_V 1.082 0.45
45_S 48_S 1.071 0.44
13_R 19_A 1.069 0.44
135_V 175_K 1.057 0.42
38_P 128_N 1.053 0.42
47_T 59_N 1.049 0.42
28_S 152_N 1.045 0.41
90_K 122_K 1.045 0.41
25_S 53_S 1.039 0.41
120_M 128_N 1.038 0.41
126_R 148_I 1.038 0.41
81_R 136_L 1.035 0.40
37_H 44_G 1.034 0.40
77_W 100_R 1.034 0.40
70_I 92_I 1.034 0.40
98_V 158_A 1.032 0.40
15_I 70_I 1.031 0.40
38_P 59_N 1.03 0.40
166_I 170_N 1.028 0.40
77_W 167_S 1.028 0.40
80_V 116_E 1.028 0.40
82_Y 111_P 1.027 0.40
7_I 33_A 1.018 0.39
178_Y 185_L 1.016 0.39
87_S 158_A 1.015 0.39
139_A 177_R 1.013 0.38
150_I 166_I 1.01 0.38
73_Q 182_R 1.008 0.38
106_F 117_Q 1.008 0.38
102_F 105_Q 1.005 0.38
92_I 181_A 1.002 0.37
106_F 121_G 1.002 0.37
73_Q 101_T 1.002 0.37
79_G 161_S 1.001 0.37
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jyxA10.67551000.416Contact Map0.414
3npfA20.93621000.451Contact Map0.379
3h41A10.93621000.454Contact Map0.388
4hpeA60.87771000.468Contact Map0.387
4fdyA20.90961000.473Contact Map0.394
2hbwA10.95211000.482Contact Map0.352
4eyzA20.81381000.486Contact Map0.229
3gt2A10.68621000.491Contact Map0.38
3pbiA10.87771000.501Contact Map0.385
4lj1A10.65961000.502Contact Map0.391
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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