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OPENSEQ.org

YCIO - Uncharacterized protein YciO
UniProt: P0AFR4 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12967
Length: 206 (201)
Sequences: 3571
Seq/Len: 17.77

YCIO
Paralog alert: 0.53 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RIMN YCIO
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_I 28_G 5.217 1.00
32_Y 41_G 3.551 1.00
43_K 46_D 3.444 1.00
28_G 169_D 3.322 1.00
76_S 86_F 2.803 1.00
47_K 108_P 2.589 1.00
22_E 26_K 2.557 1.00
18_N 135_A 2.434 1.00
27_G 46_D 2.264 1.00
70_R 74_E 2.11 1.00
32_Y 129_A 2.052 1.00
43_K 138_E 2.047 1.00
52_R 55_R 1.978 1.00
69_C 75_L 1.933 1.00
63_H 148_P 1.906 1.00
41_G 142_S 1.894 1.00
150_S 163_R 1.887 1.00
47_K 110_R 1.865 1.00
71_D 134_E 1.852 1.00
29_V 56_I 1.73 1.00
44_I 67_L 1.714 1.00
24_V 136_L 1.708 1.00
31_V 168_V 1.693 1.00
70_R 133_L 1.661 1.00
35_D 126_N 1.651 1.00
157_P 173_H 1.645 1.00
19_Q 22_E 1.637 1.00
156_D 159_E 1.625 1.00
147_L 163_R 1.622 1.00
45_E 138_E 1.6 1.00
86_F 90_K 1.589 1.00
161_K 165_E 1.579 1.00
51_E 55_R 1.576 1.00
17_I 135_A 1.563 1.00
23_I 170_L 1.557 1.00
201_D 204_P 1.549 1.00
131_A 134_E 1.54 1.00
42_C 49_A 1.51 1.00
31_V 160_I 1.494 1.00
38_Y 157_P 1.458 1.00
79_S 101_L 1.438 1.00
79_S 119_I 1.423 1.00
128_I 174_G 1.421 1.00
41_G 140_M 1.416 1.00
118_T 186_D 1.408 1.00
28_G 52_R 1.387 0.99
78_Y 121_M 1.383 0.99
21_V 135_A 1.381 0.99
47_K 51_E 1.377 0.99
74_E 77_T 1.37 0.99
82_D 85_A 1.358 0.99
73_S 76_S 1.353 0.99
128_I 172_I 1.344 0.99
72_L 90_K 1.341 0.99
46_D 49_A 1.298 0.99
186_D 189_D 1.276 0.99
68_M 142_S 1.268 0.99
75_L 121_M 1.255 0.99
56_I 167_Q 1.253 0.99
23_I 169_D 1.246 0.98
160_I 171_I 1.245 0.98
21_V 25_R 1.241 0.98
20_A 132_L 1.24 0.98
80_F 102_K 1.231 0.98
178_G 199_V 1.229 0.98
89_M 99_F 1.223 0.98
56_I 164_L 1.217 0.98
161_K 171_I 1.211 0.98
53_I 141_L 1.211 0.98
194_V 202_V 1.209 0.98
69_C 78_Y 1.204 0.98
54_C 61_D 1.203 0.98
52_R 56_I 1.196 0.98
21_V 136_L 1.193 0.98
32_Y 132_L 1.189 0.98
70_R 134_E 1.186 0.98
72_L 123_V 1.172 0.98
83_N 86_F 1.168 0.97
187_L 192_P 1.152 0.97
145_L 160_I 1.136 0.97
79_S 121_M 1.131 0.97
127_P 131_A 1.131 0.97
71_D 74_E 1.116 0.96
22_E 25_R 1.113 0.96
98_T 120_G 1.113 0.96
147_L 167_Q 1.112 0.96
31_V 157_P 1.11 0.96
103_G 113_Q 1.108 0.96
186_D 192_P 1.107 0.96
32_Y 142_S 1.103 0.96
66_T 120_G 1.089 0.96
81_V 89_M 1.076 0.95
51_E 110_R 1.075 0.95
20_A 30_I 1.07 0.95
123_V 130_Q 1.068 0.95
132_L 172_I 1.05 0.94
158_E 162_D 1.049 0.94
59_L 146_M 1.047 0.94
100_I 195_V 1.033 0.94
102_K 117_K 1.029 0.94
69_C 123_V 1.027 0.94
24_V 140_M 1.026 0.94
9_P 12_P 1.019 0.93
159_E 163_R 1.016 0.93
154_E 160_I 1.006 0.93
75_L 81_V 1.002 0.92
31_V 40_L 1.002 0.92
136_L 139_P 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2eqaA10.99031000.039Contact Map0.867
1k7jA111000.1Contact Map0.757
1jcuA10.97091000.112Contact Map0.366
3l7vA10.97091000.139Contact Map0.529
3vthA20.97571000.172Contact Map0.753
1hruA20.89321000.184Contact Map0.759
4g9iA60.97571000.199Contact Map0.744
3ttcA10.93691000.242Contact Map0.682
3venA10.8301960.886Contact Map0.63
1x9aA20.422319.80.948Contact Map0.076

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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