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OPENSEQ.org
YBHR - Inner membrane transport permease YbhR
UniProt: P0AFP9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13674
Length: 368 (366)
Sequences: 3088
Seq/Len: 8.44
YBHR
Paralog alert: 0.78 [within 20: 0.45] - ratio of genomes with paralogs
Cluster includes: YBHR YBHS YHHJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_A 95_A 5.794 1.00
82_S 85_E 3.879 1.00
86_I 98_L 3.791 1.00
104_D 108_K 3.785 1.00
259_T 327_I 3.429 1.00
4_R 217_Q 3.06 1.00
108_K 113_Q 3.02 1.00
54_D 61_S 2.751 1.00
12_E 222_K 2.732 1.00
10_R 14_Q 2.71 1.00
8_L 221_G 2.661 1.00
52_I 65_T 2.655 1.00
199_E 222_K 2.616 1.00
235_T 257_Y 2.615 1.00
89_T 95_A 2.605 1.00
9_I 224_V 2.555 1.00
342_W 346_W 2.525 1.00
5_L 9_I 2.514 1.00
99_V 119_L 2.478 1.00
51_A 80_L 2.477 1.00
58_G 61_S 2.368 1.00
260_M 324_F 2.352 1.00
56_D 106_S 2.347 1.00
101_F 105_F 2.277 1.00
88_P 92_T 2.244 1.00
53_Y 86_I 2.223 1.00
265_L 352_T 2.15 1.00
68_F 136_L 2.106 1.00
47_N 75_T 2.083 1.00
104_D 107_R 2.083 1.00
346_W 350_V 2.07 1.00
51_A 89_T 2.063 1.00
54_D 58_G 2.05 1.00
89_T 94_K 1.912 1.00
316_T 322_R 1.902 1.00
330_Q 336_A 1.89 1.00
90_I 98_L 1.876 1.00
61_S 106_S 1.871 1.00
11_K 199_E 1.865 1.00
199_E 204_T 1.855 1.00
54_D 57_N 1.846 1.00
276_S 362_M 1.827 1.00
262_I 349_L 1.824 1.00
87_R 91_D 1.823 1.00
234_A 260_M 1.82 1.00
239_A 243_W 1.758 1.00
350_V 354_T 1.732 1.00
305_V 316_T 1.67 1.00
80_L 89_T 1.666 1.00
55_E 100_R 1.661 1.00
310_V 314_N 1.658 1.00
81_K 85_E 1.657 1.00
6_W 10_R 1.648 1.00
96_L 122_D 1.625 1.00
56_D 104_D 1.607 1.00
317_W 323_H 1.602 1.00
227_L 261_V 1.59 1.00
58_G 106_S 1.575 1.00
5_L 224_V 1.573 1.00
38_P 245_Y 1.552 1.00
97_L 132_A 1.546 1.00
326_D 344_S 1.543 1.00
214_T 217_Q 1.512 1.00
270_F 291_F 1.505 1.00
39_F 244_A 1.502 1.00
313_Q 317_W 1.5 1.00
259_T 345_L 1.482 1.00
208_L 218_I 1.438 0.99
60_H 109_L 1.437 0.99
64_L 140_V 1.432 0.99
49_T 77_V 1.423 0.99
231_T 235_T 1.418 0.99
337_S 340_I 1.415 0.99
95_A 98_L 1.415 0.99
60_H 106_S 1.414 0.99
347_P 351_I 1.409 0.99
50_I 99_V 1.377 0.99
56_D 101_F 1.356 0.99
85_E 89_T 1.348 0.99
55_E 83_P 1.344 0.99
14_Q 17_L 1.339 0.99
85_E 88_P 1.331 0.99
100_R 120_I 1.326 0.99
9_I 228_I 1.314 0.99
259_T 331_I 1.304 0.98
303_S 307_N 1.302 0.98
330_Q 334_K 1.302 0.98
273_L 358_A 1.301 0.98
278_C 283_Q 1.28 0.98
266_S 352_T 1.279 0.98
269_G 352_T 1.262 0.98
256_F 328_T 1.261 0.98
49_T 96_L 1.26 0.98
223_A 265_L 1.259 0.98
308_M 313_Q 1.255 0.98
6_W 9_I 1.249 0.98
78_L 94_K 1.248 0.98
53_Y 80_L 1.236 0.98
5_L 220_I 1.236 0.98
119_L 136_L 1.234 0.98
83_P 87_R 1.224 0.97
230_A 264_G 1.219 0.97
345_L 349_L 1.219 0.97
317_W 322_R 1.217 0.97
51_A 98_L 1.213 0.97
280_T 283_Q 1.209 0.97
343_N 347_P 1.202 0.97
216_W 360_Y 1.202 0.97
11_K 222_K 1.2 0.97
336_A 340_I 1.199 0.97
5_L 217_Q 1.199 0.97
228_I 232_F 1.194 0.97
66_Q 69_A 1.19 0.97
255_L 331_I 1.179 0.97
97_L 136_L 1.173 0.97
54_D 106_S 1.167 0.96
254_A 258_F 1.163 0.96
323_H 344_S 1.162 0.96
357_S 361_A 1.162 0.96
266_S 355_T 1.158 0.96
63_E 66_Q 1.146 0.96
349_L 353_A 1.143 0.96
83_P 98_L 1.138 0.96
50_I 97_L 1.135 0.96
240_I 244_A 1.134 0.96
83_P 100_R 1.125 0.95
262_I 352_T 1.124 0.95
69_A 76_H 1.102 0.95
311_W 315_L 1.1 0.95
19_E 22_T 1.093 0.94
216_W 220_I 1.091 0.94
8_L 213_L 1.089 0.94
67_R 146_E 1.088 0.94
311_W 314_N 1.087 0.94
221_G 225_P 1.086 0.94
339_D 342_W 1.086 0.94
181_A 295_A 1.073 0.94
49_T 75_T 1.071 0.93
101_F 117_L 1.069 0.93
13_L 225_P 1.068 0.93
4_R 7_T 1.067 0.93
78_L 89_T 1.066 0.93
90_I 93_Q 1.046 0.92
181_A 321_I 1.037 0.92
106_S 110_D 1.035 0.92
86_I 89_T 1.031 0.92
35_I 240_I 1.025 0.91
56_D 61_S 1.022 0.91
327_I 348_L 1.017 0.91
271_G 275_S 1.015 0.91
310_V 313_Q 1.013 0.91
284_A 288_V 1.006 0.90
61_S 101_F 1.004 0.90
238_L 249_F 1.002 0.90
90_I 95_A 1.001 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3cniA10.399599.80.705Contact Map0.641
2p0sA20.3587980.874Contact Map0.559
2plnA10.315213.70.961Contact Map0.604
1xhfA20.304312.80.961Contact Map0.712
1dz3A10.309811.20.962Contact Map0.607
2lpmA10.31529.30.964Contact Map0.526
2zayA20.35338.80.964Contact Map0.716
1jbeA10.30988.80.964Contact Map0.581
2a9oA10.29898.60.964Contact Map0.558
3i42A10.30438.40.964Contact Map0.58
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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