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OPENSEQ.org
PPX - Exopolyphosphatase
UniProt: P0AFL6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11403
Length: 513 (493)
Sequences: 1042
Seq/Len: 2.11
PPX
Paralog alert: 0.37 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GPPA PPX
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
345_E 360_E 3.501 1.00
219_T 274_G 2.903 1.00
63_T 67_N 2.855 1.00
385_S 409_V 2.706 1.00
173_A 273_P 2.588 1.00
56_M 96_L 2.414 1.00
384_H 387_Y 2.322 1.00
87_V 301_V 2.303 1.00
142_I 281_V 2.289 1.00
105_A 113_I 2.154 1.00
17_D 21_N 2.099 0.99
39_G 447_N 2.097 0.99
341_M 345_E 2.078 0.99
389_L 409_V 2.065 0.99
220_I 278_L 2.058 0.99
493_W 497_A 1.99 0.99
73_A 77_Q 1.953 0.99
85_C 114_E 1.952 0.99
59_E 104_R 1.945 0.99
57_L 101_F 1.915 0.99
356_H 359_L 1.909 0.99
282_F 290_L 1.906 0.99
315_R 397_F 1.894 0.99
18_L 23_F 1.876 0.98
120_E 123_R 1.868 0.98
65_G 101_F 1.858 0.98
76_L 84_V 1.826 0.98
226_V 271_F 1.814 0.98
376_I 388_I 1.791 0.98
151_L 281_V 1.791 0.98
125_I 217_S 1.748 0.97
24_H 296_A 1.72 0.97
343_M 438_L 1.713 0.97
88_G 92_L 1.707 0.97
106_E 112_P 1.693 0.96
381_L 412_H 1.642 0.96
337_L 364_R 1.63 0.95
101_F 105_A 1.61 0.95
341_M 360_E 1.582 0.94
170_V 270_V 1.566 0.94
215_G 220_I 1.559 0.94
470_R 504_E 1.556 0.94
14_A 84_V 1.553 0.93
332_Q 335_R 1.54 0.93
195_A 280_G 1.532 0.93
18_L 113_I 1.52 0.93
86_I 111_Y 1.508 0.92
466_H 502_K 1.507 0.92
14_A 76_L 1.503 0.92
359_L 431_Q 1.496 0.92
92_L 101_F 1.494 0.92
123_R 304_E 1.492 0.92
118_G 150_E 1.491 0.92
59_E 63_T 1.462 0.90
88_G 115_I 1.456 0.90
28_A 302_L 1.451 0.90
468_T 502_K 1.449 0.90
26_V 299_E 1.447 0.90
365_W 397_F 1.444 0.90
66_L 101_F 1.437 0.89
100_D 103_K 1.431 0.89
21_N 150_E 1.424 0.89
249_V 275_L 1.419 0.89
21_N 267_R 1.418 0.89
198_L 281_V 1.41 0.88
89_T 93_R 1.409 0.88
65_G 92_L 1.389 0.87
120_E 304_E 1.385 0.87
347_W 438_L 1.375 0.86
105_A 109_I 1.373 0.86
243_E 283_D 1.368 0.86
17_D 22_S 1.363 0.86
132_T 295_G 1.362 0.86
62_M 97_N 1.359 0.86
194_A 276_A 1.358 0.86
344_Y 360_E 1.356 0.85
92_L 105_A 1.348 0.85
70_S 108_V 1.343 0.85
123_R 127_M 1.343 0.85
217_S 296_A 1.338 0.84
17_D 218_G 1.318 0.83
145_G 148_S 1.316 0.83
27_I 39_G 1.307 0.82
154_G 217_S 1.306 0.82
269_T 272_V 1.304 0.82
118_G 122_A 1.304 0.82
459_T 470_R 1.302 0.82
415_A 445_L 1.301 0.82
467_W 493_W 1.3 0.82
61_A 97_N 1.295 0.82
227_L 241_R 1.29 0.81
97_N 147_G 1.288 0.81
21_N 42_K 1.287 0.81
99_T 103_K 1.286 0.81
412_H 445_L 1.283 0.81
463_D 466_H 1.283 0.81
22_S 150_E 1.283 0.81
218_G 267_R 1.282 0.81
23_F 72_F 1.282 0.81
328_I 372_V 1.279 0.81
232_E 399_Q 1.272 0.80
22_S 42_K 1.268 0.80
138_R 155_E 1.266 0.80
249_V 258_L 1.255 0.79
17_D 150_E 1.253 0.79
25_M 328_I 1.25 0.78
400_E 428_K 1.239 0.78
143_D 267_R 1.238 0.77
87_V 297_L 1.238 0.77
494_E 500_R 1.237 0.77
197_K 200_T 1.231 0.77
294_D 343_M 1.226 0.77
17_D 148_S 1.225 0.76
52_G 56_M 1.224 0.76
144_I 149_T 1.221 0.76
90_H 171_S 1.22 0.76
21_N 218_G 1.22 0.76
24_H 299_E 1.219 0.76
42_K 150_E 1.219 0.76
267_R 298_R 1.216 0.76
362_L 404_M 1.216 0.76
24_H 217_S 1.213 0.75
24_H 40_R 1.21 0.75
27_I 79_F 1.208 0.75
483_L 487_E 1.203 0.75
122_A 150_E 1.201 0.74
146_G 298_R 1.199 0.74
122_A 267_R 1.197 0.74
239_P 283_D 1.193 0.74
17_D 145_G 1.191 0.74
416_I 493_W 1.191 0.74
17_D 267_R 1.19 0.73
17_D 146_G 1.19 0.73
24_H 302_L 1.188 0.73
62_M 104_R 1.165 0.71
347_W 351_Q 1.162 0.71
122_A 148_S 1.161 0.71
21_N 164_S 1.159 0.71
71_L 378_H 1.158 0.71
94_Q 171_S 1.158 0.71
17_D 20_S 1.158 0.71
147_G 171_S 1.152 0.70
88_G 416_I 1.15 0.70
223_A 275_L 1.147 0.69
16_V 86_I 1.146 0.69
149_T 387_Y 1.145 0.69
148_S 267_R 1.144 0.69
146_G 267_R 1.141 0.69
341_M 364_R 1.141 0.69
122_A 143_D 1.14 0.69
15_A 120_E 1.134 0.68
17_D 122_A 1.131 0.68
265_E 268_K 1.124 0.67
103_K 107_K 1.123 0.67
176_Y 193_A 1.123 0.67
119_N 197_K 1.12 0.67
146_G 150_E 1.117 0.67
46_H 270_V 1.117 0.67
121_E 218_G 1.115 0.66
143_D 146_G 1.115 0.66
150_E 218_G 1.115 0.66
383_R 412_H 1.107 0.66
398_N 401_Q 1.106 0.65
412_H 443_V 1.102 0.65
66_L 105_A 1.101 0.65
62_M 101_F 1.101 0.65
488_K 500_R 1.099 0.65
18_L 88_G 1.099 0.65
21_N 146_G 1.099 0.65
167_M 198_L 1.097 0.64
98_A 115_I 1.096 0.64
21_N 24_H 1.095 0.64
142_I 213_A 1.095 0.64
58_S 61_A 1.094 0.64
143_D 148_S 1.094 0.64
215_G 278_L 1.093 0.64
293_S 372_V 1.091 0.64
205_F 209_G 1.091 0.64
102_L 108_V 1.09 0.64
59_E 66_L 1.088 0.64
16_V 108_V 1.087 0.63
221_K 232_E 1.086 0.63
118_G 146_G 1.08 0.63
191_R 283_D 1.078 0.62
226_V 263_L 1.078 0.62
122_A 218_G 1.075 0.62
388_I 394_L 1.074 0.62
87_V 116_I 1.071 0.62
322_L 372_V 1.07 0.62
339_T 446_N 1.068 0.61
223_A 249_V 1.067 0.61
243_E 247_K 1.064 0.61
17_D 143_D 1.063 0.61
145_G 267_R 1.063 0.61
169_C 270_V 1.062 0.61
188_Q 283_D 1.062 0.61
14_A 29_R 1.061 0.61
104_R 107_K 1.061 0.61
332_Q 371_E 1.058 0.60
217_S 315_R 1.058 0.60
326_Y 392_S 1.057 0.60
21_N 121_E 1.056 0.60
64_R 274_G 1.054 0.60
223_A 271_F 1.051 0.60
38_I 391_N 1.049 0.59
150_E 164_S 1.048 0.59
118_G 145_G 1.048 0.59
22_S 118_G 1.048 0.59
131_H 157_F 1.046 0.59
195_A 283_D 1.043 0.59
337_L 368_M 1.043 0.59
315_R 365_W 1.042 0.59
21_N 122_A 1.041 0.58
146_G 218_G 1.041 0.58
61_A 64_R 1.041 0.58
218_G 298_R 1.039 0.58
90_H 147_G 1.036 0.58
104_R 198_L 1.035 0.58
38_I 100_D 1.035 0.58
21_N 145_G 1.034 0.58
59_E 100_D 1.032 0.57
19_G 22_S 1.03 0.57
42_K 46_H 1.029 0.57
133_Q 214_M 1.027 0.57
325_Q 392_S 1.027 0.57
247_K 435_L 1.027 0.57
113_I 152_V 1.025 0.57
282_F 287_I 1.024 0.57
246_V 275_L 1.022 0.56
24_H 46_H 1.022 0.56
462_T 467_W 1.021 0.56
19_G 143_D 1.02 0.56
122_A 144_I 1.019 0.56
28_A 217_S 1.018 0.56
371_E 381_L 1.017 0.56
437_Q 499_W 1.017 0.56
121_E 267_R 1.015 0.56
385_S 412_H 1.014 0.55
122_A 146_G 1.012 0.55
14_A 19_G 1.011 0.55
17_D 24_H 1.01 0.55
366_A 405_M 1.007 0.55
154_G 315_R 1.005 0.54
93_R 150_E 1.005 0.54
191_R 280_G 1.004 0.54
29_R 36_Q 1.003 0.54
17_D 93_R 1.003 0.54
48_A 171_S 1.002 0.54
253_R 256_A 1.001 0.54
17_D 89_T 1.001 0.54
137_G 155_E 1 0.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1u6zA20.99421000.099Contact Map0.515
3hi0A20.95131000.217Contact Map0.464
3cerA50.60821000.499Contact Map0.516
1t6cA10.59451000.507Contact Map0.472
3mdqA10.59651000.514Contact Map0.488
4brcA20.59651000.662Contact Map0.272
3rf0A20.38991000.689Contact Map0.65
3cj1A10.63161000.758Contact Map0.287
3zx3A40.61011000.766Contact Map0.342
3h1qA20.458199.70.873Contact Map0.217
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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