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OPENSEQ.org
ODO2 - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex
UniProt: P0AFG6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10980
Length: 405 (404)
Sequences: 3723
Seq/Len: 9.22
ODO2
Paralog alert: 0.79 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ODO2 ODP2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
301_E 305_K 4.019 1.00
27_P 59_A 3.773 1.00
357_A 362_V 3.43 1.00
25_K 35_E 3.34 1.00
353_D 360_G 3.093 1.00
290_L 298_K 3.033 1.00
304_V 308_D 2.977 1.00
298_K 301_E 2.932 1.00
63_D 66_T 2.915 1.00
248_R 390_T 2.915 1.00
187_R 190_E 2.86 1.00
208_V 370_L 2.77 1.00
58_D 78_R 2.733 1.00
32_V 54_D 2.723 1.00
59_A 76_R 2.632 1.00
25_K 57_L 2.632 1.00
128_D 131_A 2.631 1.00
207_E 354_R 2.606 1.00
305_K 315_D 2.534 1.00
255_S 264_H 2.5 1.00
239_V 269_V 2.413 1.00
22_T 64_E 2.381 1.00
209_N 365_L 2.376 1.00
177_K 265_N 2.344 1.00
242_V 321_F 2.325 1.00
24_H 36_V 2.32 1.00
357_A 364_I 2.298 1.00
62_E 72_Q 2.29 1.00
249_Y 390_T 2.268 1.00
201_M 373_S 2.221 1.00
290_L 294_D 2.183 1.00
247_K 288_D 2.138 1.00
268_D 285_R 2.098 1.00
178_R 260_D 2.089 1.00
270_S 281_T 2.042 1.00
246_L 321_F 2.024 1.00
242_V 391_I 2.014 1.00
20_V 38_V 1.984 1.00
266_Y 286_D 1.982 1.00
61_L 76_R 1.953 1.00
353_D 366_P 1.937 1.00
61_L 73_I 1.934 1.00
38_V 74_L 1.92 1.00
306_G 311_L 1.918 1.00
131_A 149_H 1.897 1.00
243_V 267_F 1.853 1.00
26_K 29_D 1.852 1.00
319_G 342_Q 1.842 1.00
143_R 147_E 1.842 1.00
33_R 54_D 1.841 1.00
57_L 60_V 1.83 1.00
32_V 35_E 1.813 1.00
122_L 129_A 1.807 1.00
57_L 75_G 1.798 1.00
181_M 256_I 1.783 1.00
127_L 132_I 1.757 1.00
5_D 76_R 1.736 1.00
243_V 287_V 1.728 1.00
179_V 263_Y 1.728 1.00
184_L 188_V 1.721 1.00
114_L 129_A 1.72 1.00
336_P 347_G 1.704 1.00
277_R 309_G 1.701 1.00
239_V 299_I 1.693 1.00
121_L 147_E 1.688 1.00
30_A 56_I 1.685 1.00
120_R 124_E 1.666 1.00
225_E 231_R 1.666 1.00
214_M 234_F 1.666 1.00
239_V 295_I 1.65 1.00
5_D 73_I 1.632 1.00
39_E 48_E 1.628 1.00
239_V 287_V 1.591 1.00
211_K 365_L 1.58 1.00
299_I 303_A 1.58 1.00
22_T 39_E 1.577 1.00
185_R 188_V 1.567 1.00
20_V 74_L 1.564 1.00
254_A 263_Y 1.562 1.00
194_E 198_S 1.561 1.00
196_K 201_M 1.54 1.00
199_T 338_I 1.517 1.00
191_R 194_E 1.516 1.00
187_R 191_R 1.508 1.00
390_T 393_E 1.5 1.00
134_G 141_L 1.5 1.00
355_P 362_V 1.482 1.00
245_A 391_I 1.481 1.00
249_Y 386_G 1.465 1.00
17_D 67_T 1.461 1.00
303_A 307_R 1.454 1.00
244_E 394_L 1.446 1.00
270_S 342_Q 1.417 0.99
125_H 150_L 1.416 0.99
69_T 72_Q 1.403 0.99
212_P 215_D 1.402 0.99
389_V 393_E 1.393 0.99
261_V 378_L 1.38 0.99
62_E 68_V 1.37 0.99
178_R 262_V 1.369 0.99
238_Y 348_M 1.358 0.99
185_R 380_D 1.358 0.99
180_P 260_D 1.357 0.99
205_F 333_M 1.353 0.99
186_K 259_D 1.351 0.99
219_Q 399_T 1.35 0.99
24_H 39_E 1.348 0.99
284_L 298_K 1.344 0.99
204_T 374_Y 1.34 0.99
251_E 383_E 1.339 0.99
239_V 271_M 1.329 0.99
286_D 289_T 1.314 0.99
6_I 75_G 1.309 0.99
121_L 146_V 1.309 0.99
203_T 373_S 1.298 0.99
204_T 384_S 1.298 0.99
209_N 358_V 1.291 0.99
7_L 73_I 1.283 0.99
254_A 378_L 1.278 0.99
267_F 288_D 1.273 0.98
27_P 60_V 1.272 0.98
358_V 363_E 1.264 0.98
239_V 323_I 1.261 0.98
211_K 215_D 1.261 0.98
122_L 127_L 1.26 0.98
353_D 364_I 1.258 0.98
207_E 332_L 1.258 0.98
222_E 225_E 1.252 0.98
268_D 283_V 1.25 0.98
251_E 263_Y 1.246 0.98
346_L 391_I 1.241 0.98
203_T 335_T 1.233 0.98
221_G 231_R 1.23 0.98
134_G 140_R 1.227 0.98
376_H 381_G 1.222 0.98
213_I 237_F 1.218 0.98
291_G 294_D 1.211 0.98
218_K 221_G 1.207 0.98
204_T 331_S 1.198 0.98
27_P 63_D 1.196 0.97
392_K 396_E 1.187 0.97
257_D 260_D 1.18 0.97
370_L 391_I 1.173 0.97
210_M 368_M 1.169 0.97
121_L 125_H 1.166 0.97
321_F 344_A 1.156 0.97
211_K 366_P 1.154 0.97
144_E 147_E 1.144 0.96
62_E 66_T 1.143 0.96
122_L 132_I 1.139 0.96
190_E 194_E 1.136 0.96
339_N 342_Q 1.13 0.96
193_L 197_N 1.126 0.96
271_M 299_I 1.123 0.96
134_G 139_G 1.121 0.96
274_S 386_G 1.117 0.96
206_N 392_K 1.111 0.96
312_T 315_D 1.109 0.96
240_K 244_E 1.104 0.95
305_K 312_T 1.103 0.95
239_V 284_L 1.102 0.95
372_L 388_L 1.1 0.95
11_L 18_A 1.098 0.95
274_S 329_F 1.096 0.95
31_V 57_L 1.094 0.95
326_G 334_S 1.093 0.95
210_M 213_I 1.092 0.95
15_V 18_A 1.091 0.95
252_V 344_A 1.089 0.95
27_P 58_D 1.087 0.95
129_A 141_L 1.083 0.95
382_R 386_G 1.079 0.95
256_I 378_L 1.077 0.95
202_L 374_Y 1.075 0.95
321_F 346_L 1.07 0.94
144_E 148_K 1.068 0.94
122_L 141_L 1.064 0.94
236_S 292_M 1.063 0.94
343_S 378_L 1.057 0.94
36_V 48_E 1.053 0.94
117_A 143_R 1.049 0.94
26_K 60_V 1.046 0.93
215_D 218_K 1.044 0.93
8_V 18_A 1.042 0.93
10_D 13_E 1.041 0.93
356_M 365_L 1.04 0.93
135_T 142_T 1.029 0.93
242_V 344_A 1.028 0.93
247_K 267_F 1.019 0.92
346_L 372_L 1.015 0.92
21_A 46_V 1.015 0.92
252_V 379_I 1.013 0.92
112_D 141_L 1.013 0.92
105_S 108_E 1.013 0.92
210_M 351_I 1.009 0.92
358_V 365_L 1.006 0.92
286_D 290_L 1.005 0.92
356_M 367_M 1.004 0.91
205_F 335_T 1.002 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3dvaI20.99511000.145Contact Map0.776
1sczA10.57531000.434Contact Map0.753
3maeA30.60991000.444Contact Map0.875
2ii3A80.63461000.444Contact Map0.81
1dpbA10.59511000.447Contact Map0.691
3b8kA10.58521000.451Contact Map0.462
3l60A10.58771000.458Contact Map0.739
3rqcA70.54811000.47Contact Map0.857
2xt6A20.52841000.498Contact Map0.773
1q23A120.52841000.57Contact Map0.626
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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