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OPENSEQ.org
ENTC - Isochorismate synthase EntC
UniProt: P0AEJ2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10261
Length: 391 (373)
Sequences: 625
Seq/Len: 1.68
ENTC
Paralog alert: 0.50 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ENTC MENF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
137_A 367_A 2.988 1.00
218_R 225_D 2.749 1.00
304_L 328_G 2.736 1.00
215_S 274_L 2.722 1.00
210_I 278_A 2.684 1.00
240_H 244_L 2.409 1.00
154_I 381_L 2.313 1.00
155_D 357_R 2.266 0.99
130_E 371_L 2.219 0.99
257_S 283_G 2.185 0.99
235_S 238_D 2.119 0.99
151_S 327_F 1.946 0.98
315_V 319_L 1.934 0.98
191_L 348_C 1.921 0.98
305_S 313_T 1.912 0.98
216_A 231_R 1.882 0.97
259_E 284_K 1.877 0.97
250_K 262_V 1.815 0.97
219_Q 224_L 1.813 0.97
139_L 318_E 1.764 0.96
136_A 150_L 1.753 0.96
229_G 268_L 1.733 0.95
369_S 372_G 1.685 0.94
35_C 38_R 1.658 0.94
77_A 326_L 1.641 0.93
335_D 339_N 1.635 0.93
145_V 315_V 1.626 0.93
201_R 341_E 1.624 0.93
236_E 240_H 1.608 0.92
238_D 372_G 1.605 0.92
152_R 377_T 1.599 0.92
268_L 275_W 1.579 0.91
134_A 370_P 1.542 0.90
256_R 297_L 1.533 0.90
140_T 366_P 1.528 0.89
228_A 275_W 1.512 0.89
242_H 279_T 1.508 0.89
133_V 137_A 1.508 0.89
181_F 348_C 1.505 0.89
358_L 384_M 1.503 0.88
151_S 322_F 1.501 0.88
314_Q 318_E 1.495 0.88
129_F 362_A 1.487 0.88
200_L 340_G 1.482 0.87
77_A 346_I 1.466 0.87
274_L 379_V 1.462 0.87
245_V 302_P 1.449 0.86
130_E 374_W 1.444 0.86
76_G 342_W 1.444 0.86
175_N 383_T 1.409 0.84
117_V 158_T 1.356 0.80
167_L 192_L 1.344 0.80
198_L 342_W 1.341 0.79
147_K 303_A 1.336 0.79
291_A 295_A 1.334 0.79
150_L 316_I 1.324 0.78
139_L 143_P 1.316 0.77
224_L 227_E 1.314 0.77
141_A 367_A 1.306 0.77
136_A 315_V 1.303 0.77
260_L 283_G 1.297 0.76
349_A 356_V 1.294 0.76
80_F 301_T 1.293 0.76
144_Q 167_L 1.291 0.76
125_E 128_T 1.28 0.75
258_S 284_K 1.274 0.74
225_D 268_L 1.272 0.74
148_V 316_I 1.272 0.74
129_F 211_P 1.267 0.74
162_I 356_V 1.253 0.72
178_S 383_T 1.249 0.72
134_A 138_A 1.245 0.72
88_L 342_W 1.244 0.72
198_L 211_P 1.242 0.72
206_R 284_K 1.241 0.71
226_R 230_N 1.24 0.71
248_A 252_V 1.236 0.71
77_A 88_L 1.235 0.71
292_L 295_A 1.234 0.71
244_L 262_V 1.225 0.70
211_P 271_T 1.225 0.70
291_A 342_W 1.22 0.70
77_A 211_P 1.215 0.69
211_P 245_V 1.214 0.69
39_F 56_K 1.213 0.69
158_T 162_I 1.212 0.69
267_Q 280_P 1.21 0.69
351_L 356_V 1.206 0.68
143_P 370_P 1.206 0.68
281_F 323_D 1.205 0.68
129_F 151_S 1.205 0.68
206_R 282_E 1.204 0.68
157_T 230_N 1.199 0.68
22_F 29_S 1.199 0.68
147_K 301_T 1.199 0.68
48_S 52_P 1.196 0.67
304_L 330_I 1.193 0.67
178_S 346_I 1.192 0.67
245_V 344_V 1.192 0.67
211_P 326_L 1.186 0.66
79_P 334_C 1.184 0.66
77_A 191_L 1.183 0.66
191_L 198_L 1.182 0.66
191_L 211_P 1.17 0.65
64_A 68_G 1.165 0.64
138_A 142_T 1.165 0.64
255_E 297_L 1.163 0.64
179_Y 210_I 1.154 0.63
266_P 277_L 1.153 0.63
219_Q 275_W 1.146 0.63
371_L 375_R 1.139 0.62
162_I 195_S 1.133 0.61
212_L 349_A 1.126 0.60
155_D 325_E 1.118 0.60
129_F 330_I 1.117 0.60
78_I 330_I 1.116 0.59
219_Q 295_A 1.116 0.59
126_Q 130_E 1.112 0.59
170_R 333_W 1.101 0.58
199_L 344_V 1.099 0.58
117_V 159_D 1.098 0.58
212_L 271_T 1.098 0.58
243_E 247_Q 1.097 0.57
219_Q 228_A 1.097 0.57
245_V 326_L 1.097 0.57
162_I 177_V 1.095 0.57
92_E 336_S 1.09 0.57
28_R 195_S 1.088 0.57
164_S 351_L 1.087 0.56
248_A 302_P 1.085 0.56
21_F 281_F 1.082 0.56
225_D 346_I 1.08 0.56
325_E 357_R 1.079 0.56
188_G 370_P 1.079 0.56
202_K 205_E 1.078 0.56
144_Q 311_A 1.075 0.55
180_N 362_A 1.074 0.55
129_F 271_T 1.073 0.55
253_L 260_L 1.072 0.55
216_A 238_D 1.07 0.55
230_N 233_L 1.069 0.55
137_A 258_S 1.068 0.54
215_S 271_T 1.067 0.54
132_M 319_L 1.059 0.53
121_Q 157_T 1.059 0.53
201_R 244_L 1.058 0.53
234_A 239_R 1.057 0.53
23_F 339_N 1.056 0.53
205_E 284_K 1.056 0.53
230_N 311_A 1.047 0.52
143_P 364_I 1.046 0.52
225_D 270_T 1.046 0.52
167_L 195_S 1.038 0.51
210_I 249_M 1.038 0.51
290_N 293_T 1.036 0.51
189_G 195_S 1.032 0.51
136_A 148_V 1.03 0.50
185_L 379_V 1.025 0.50
218_R 346_I 1.024 0.50
158_T 247_Q 1.023 0.50
362_A 378_G 1.021 0.49
195_S 343_V 1.016 0.49
305_S 329_G 1.016 0.49
32_T 304_L 1.016 0.49
271_T 302_P 1.015 0.49
216_A 239_R 1.015 0.49
250_K 254_R 1.011 0.48
128_T 131_Q 1.009 0.48
84_Q 323_D 1.004 0.48
209_S 212_L 1.003 0.48
269_I 330_I 1.003 0.48
23_F 274_L 1.003 0.48
203_D 247_Q 1.002 0.47
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3hwoA211000.22Contact Map0.545
3os6A40.97951000.249Contact Map0.574
3bzmA10.9541000.305Contact Map0.531
3gseA10.95651000.309Contact Map0.501
3h9mA10.96161000.353Contact Map0.475
1qdlA10.97951000.361Contact Map0.576
2fn0A20.9771000.361Contact Map0.521
3logA40.98211000.373Contact Map0.539
4grhA10.99231000.382Contact Map0.414
1k0eA20.98721000.385Contact Map0.509
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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