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OPENSEQ.org
DAPE - Succinyl-diaminopimelate desuccinylase
UniProt: P0AED7 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10208
Length: 375 (371)
Sequences: 12874
Seq/Len: 34.70
DAPE
Paralog alert: 0.89 [within 20: 0.19] - ratio of genomes with paralogs
Cluster includes: ABGA ABGB ALLC ARGE DAPE PEPT YGEY
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
186_T 249_E 3.275 1.00
30_I 34_Q 3.068 1.00
192_G 200_A 3.061 1.00
54_W 126_A 3.044 1.00
272_L 276_E 2.822 1.00
310_H 372_Q 2.776 1.00
269_A 273_A 2.766 1.00
186_T 251_F 2.712 1.00
188_H 281_R 2.7 1.00
206_R 280_L 2.682 1.00
268_K 272_L 2.667 1.00
306_N 372_Q 2.667 1.00
187_I 210_F 2.663 1.00
91_M 353_C 2.571 1.00
79_I 351_N 2.564 1.00
310_H 368_R 2.52 1.00
186_T 283_T 2.487 1.00
207_A 236_I 2.443 1.00
32_R 35_A 2.437 1.00
60_T 124_R 2.43 1.00
309_E 315_K 2.409 1.00
188_H 283_T 2.347 1.00
188_H 249_E 2.323 1.00
30_I 42_R 2.314 1.00
184_N 251_F 2.297 1.00
11_Q 28_L 2.289 1.00
184_N 285_D 2.265 1.00
207_A 250_L 2.17 1.00
207_A 252_V 2.166 1.00
33_L 53_A 2.166 1.00
36_I 112_E 2.138 1.00
113_R 367_Q 2.137 1.00
368_R 371_E 2.123 1.00
208_A 211_L 2.115 1.00
27_A 31_E 2.1 1.00
305_V 309_E 2.041 1.00
237_Q 251_F 2.036 1.00
80_N 88_R 2.02 1.00
11_Q 24_G 2.017 1.00
184_N 253_Q 2.001 1.00
186_T 285_D 1.996 1.00
24_G 27_A 1.977 1.00
31_E 35_A 1.964 1.00
29_L 67_T 1.924 1.00
238_A 250_L 1.903 1.00
210_F 275_L 1.851 1.00
113_R 117_Q 1.834 1.00
81_P 84_E 1.795 1.00
28_L 32_R 1.784 1.00
190_V 201_D 1.784 1.00
90_G 357_A 1.767 1.00
304_V 369_I 1.759 1.00
270_Q 273_A 1.744 1.00
265_E 269_A 1.739 1.00
60_T 126_A 1.737 1.00
23_A 27_A 1.729 1.00
62_A 155_L 1.71 1.00
80_N 84_E 1.706 1.00
142_V 146_E 1.704 1.00
54_W 124_R 1.674 1.00
201_D 206_R 1.673 1.00
27_A 42_R 1.663 1.00
203_P 250_L 1.662 1.00
209_P 212_N 1.656 1.00
15_R 28_L 1.655 1.00
235_N 253_Q 1.642 1.00
307_A 372_Q 1.635 1.00
106_A 362_L 1.622 1.00
112_E 116_A 1.615 1.00
266_M 270_Q 1.59 1.00
63_F 107_M 1.564 1.00
30_I 51_F 1.563 1.00
187_I 207_A 1.558 1.00
11_Q 14_R 1.552 1.00
38_F 55_R 1.551 1.00
34_Q 42_R 1.551 1.00
204_V 236_I 1.548 1.00
208_A 212_N 1.546 1.00
263_T 266_M 1.54 1.00
302_D 305_V 1.539 1.00
62_A 128_L 1.519 1.00
32_R 36_I 1.511 1.00
191_Q 248_G 1.469 1.00
10_Q 14_R 1.459 1.00
31_E 34_Q 1.447 1.00
26_Q 67_T 1.446 1.00
331_A 337_V 1.426 1.00
17_S 25_C 1.412 1.00
55_R 115_V 1.41 1.00
13_I 94_G 1.41 1.00
30_I 40_V 1.396 0.99
201_D 280_L 1.373 0.99
34_Q 40_V 1.368 0.99
275_L 282_Y 1.359 0.99
19_S 135_A 1.356 0.99
187_I 206_R 1.354 0.99
7_E 11_Q 1.351 0.99
87_I 356_A 1.348 0.99
115_V 118_H 1.348 0.99
143_K 146_E 1.342 0.99
308_V 365_M 1.336 0.99
361_L 364_R 1.33 0.99
213_E 277_K 1.324 0.99
266_M 269_A 1.318 0.99
8_L 28_L 1.315 0.99
10_Q 87_I 1.314 0.99
360_Q 364_R 1.307 0.99
304_V 338_V 1.306 0.99
205_H 215_V 1.305 0.99
29_L 104_L 1.293 0.99
157_Y 373_L 1.282 0.99
185_L 252_V 1.281 0.99
63_F 370_M 1.279 0.99
23_A 49_Q 1.276 0.99
306_N 310_H 1.267 0.99
368_R 372_Q 1.266 0.99
307_A 368_R 1.266 0.99
8_L 32_R 1.264 0.99
7_E 10_Q 1.263 0.99
11_Q 15_R 1.262 0.99
14_R 87_I 1.26 0.99
14_R 84_E 1.257 0.99
204_V 238_A 1.252 0.99
229_T 267_I 1.251 0.99
273_A 277_K 1.24 0.98
10_Q 356_A 1.238 0.98
184_N 287_W 1.232 0.98
303_A 307_A 1.228 0.98
65_G 100_M 1.226 0.98
28_L 31_E 1.223 0.98
10_Q 85_P 1.219 0.98
227_P 260_T 1.218 0.98
269_A 272_L 1.217 0.98
357_A 361_L 1.216 0.98
107_M 127_F 1.211 0.98
183_C 254_F 1.204 0.98
268_K 286_W 1.203 0.98
62_A 158_C 1.2 0.98
302_D 306_N 1.198 0.98
185_L 210_F 1.191 0.98
13_I 97_A 1.19 0.98
8_L 109_V 1.178 0.98
272_L 284_V 1.177 0.98
5_V 363_A 1.176 0.98
305_V 318_L 1.172 0.98
27_A 30_I 1.167 0.97
303_A 372_Q 1.161 0.97
5_V 109_V 1.161 0.97
123_G 374_V 1.161 0.97
90_G 355_N 1.158 0.97
181_L 264_D 1.155 0.97
32_R 112_E 1.153 0.97
26_Q 51_F 1.151 0.97
110_A 367_Q 1.149 0.97
211_L 252_V 1.148 0.97
12_L 28_L 1.148 0.97
205_H 216_A 1.139 0.97
213_E 274_L 1.135 0.97
268_K 288_L 1.133 0.97
196_Y 199_L 1.111 0.96
65_G 104_L 1.111 0.96
306_N 309_E 1.106 0.96
24_G 28_L 1.089 0.96
55_R 127_F 1.083 0.96
6_I 10_Q 1.079 0.95
113_R 364_R 1.073 0.95
39_T 54_W 1.069 0.95
213_E 216_A 1.069 0.95
67_T 104_L 1.066 0.95
40_V 53_A 1.066 0.95
236_I 250_L 1.066 0.95
183_C 268_K 1.06 0.95
91_M 355_N 1.058 0.95
211_L 233_I 1.055 0.95
117_Q 371_E 1.055 0.95
205_H 211_L 1.054 0.95
355_N 358_D 1.054 0.95
75_A 351_N 1.05 0.94
14_R 85_P 1.047 0.94
311_Y 368_R 1.043 0.94
354_V 359_L 1.041 0.94
5_V 105_A 1.032 0.94
211_L 236_I 1.028 0.94
59_E 156_D 1.026 0.94
213_E 278_H 1.026 0.94
187_I 252_V 1.026 0.94
188_H 248_G 1.025 0.93
364_R 368_R 1.022 0.93
158_C 335_A 1.021 0.93
60_T 156_D 1.015 0.93
12_L 25_C 1.006 0.93
301_V 338_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3iszA211000.153Contact Map0.793
1vgyA211000.159Contact Map0.705
3pfoA20.97071000.19Contact Map0.729
1cg2A40.95471000.253Contact Map0.702
4g1pA10.99471000.253Contact Map0.716
2f7vA10.93071000.255Contact Map0.551
3ct9A20.9121000.256Contact Map0.676
3gb0A10.9361000.257Contact Map0.715
2zogA20.98931000.258Contact Map0.68
3rzaA20.9361000.258Contact Map0.737
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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