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OPENSEQ.org
YNAI - Low conductance mechanosensitive channel YnaI
UniProt: P0AEB5 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13924
Length: 343 (324)
Sequences: 761
Seq/Len: 2.35
YNAI
Paralog alert: 0.23 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MSCS YBDG YNAI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
257_A 320_H 2.61 1.00
91_T 130_L 2.386 1.00
197_A 207_T 2.323 1.00
258_V 313_I 2.32 1.00
282_A 287_N 1.92 0.99
328_S 332_Y 1.811 0.98
278_F 286_L 1.747 0.98
265_H 308_D 1.716 0.97
242_G 285_S 1.685 0.97
259_R 263_K 1.68 0.97
261_M 312_K 1.597 0.96
280_Q 287_N 1.591 0.95
181_I 223_S 1.579 0.95
249_A 315_D 1.559 0.95
298_V 301_E 1.535 0.94
269_D 272_Q 1.515 0.94
247_D 250_K 1.513 0.94
258_V 288_I 1.508 0.93
186_R 227_E 1.487 0.93
296_T 301_E 1.486 0.93
159_A 164_L 1.436 0.91
184_W 291_Y 1.426 0.91
290_V 313_I 1.42 0.90
317_V 322_A 1.416 0.90
209_F 291_Y 1.414 0.90
291_Y 299_W 1.4 0.90
245_Y 281_F 1.392 0.89
53_I 57_V 1.383 0.89
15_I 18_G 1.376 0.89
268_I 292_C 1.375 0.88
48_L 125_T 1.371 0.88
268_I 294_T 1.37 0.88
104_Q 125_T 1.368 0.88
253_V 319_S 1.359 0.88
186_R 193_E 1.358 0.88
241_I 313_I 1.332 0.86
145_L 173_L 1.324 0.86
277_Y 304_A 1.32 0.86
184_W 293_F 1.312 0.85
188_P 191_N 1.31 0.85
278_F 310_Y 1.304 0.85
185_I 308_D 1.299 0.84
118_M 288_I 1.296 0.84
44_A 64_V 1.292 0.84
87_A 130_L 1.287 0.84
251_V 288_I 1.28 0.83
315_D 319_S 1.279 0.83
57_V 79_D 1.278 0.83
178_P 205_K 1.277 0.83
250_K 253_V 1.272 0.83
20_C 40_F 1.268 0.82
21_A 31_R 1.267 0.82
243_L 323_D 1.258 0.82
242_G 245_Y 1.255 0.81
196_V 224_I 1.252 0.81
25_L 31_R 1.242 0.80
14_V 18_G 1.237 0.80
275_L 291_Y 1.234 0.80
202_R 218_N 1.233 0.80
126_I 133_L 1.226 0.79
196_V 243_L 1.225 0.79
14_V 20_C 1.218 0.79
27_S 36_K 1.215 0.78
241_I 324_F 1.212 0.78
15_I 19_S 1.209 0.78
88_V 146_L 1.209 0.78
142_L 183_D 1.206 0.78
184_W 302_W 1.204 0.78
170_G 314_I 1.202 0.77
19_S 23_L 1.193 0.77
316_I 320_H 1.192 0.77
184_W 209_F 1.188 0.76
184_W 193_E 1.185 0.76
301_E 304_A 1.175 0.75
21_A 35_R 1.169 0.75
292_C 301_E 1.167 0.74
204_T 218_N 1.165 0.74
243_L 251_V 1.164 0.74
101_F 122_I 1.159 0.74
28_F 32_R 1.159 0.74
128_V 132_L 1.157 0.74
220_L 225_S 1.156 0.73
53_I 118_M 1.149 0.73
161_K 165_S 1.144 0.72
176_D 202_R 1.141 0.72
293_F 299_W 1.14 0.72
20_C 24_I 1.139 0.72
26_M 36_K 1.136 0.72
251_V 290_V 1.135 0.71
254_I 317_V 1.131 0.71
168_F 172_M 1.129 0.71
325_A 328_S 1.128 0.71
256_E 260_E 1.126 0.71
18_G 41_L 1.124 0.70
247_D 251_V 1.121 0.70
51_T 89_I 1.118 0.70
244_R 325_A 1.117 0.70
242_G 327_P 1.114 0.69
111_D 323_D 1.112 0.69
151_I 155_A 1.107 0.69
26_M 40_F 1.105 0.69
152_G 178_P 1.104 0.68
168_F 231_R 1.101 0.68
302_W 306_Q 1.096 0.68
312_K 315_D 1.095 0.68
44_A 78_I 1.093 0.67
303_L 307_Q 1.089 0.67
28_F 40_F 1.088 0.67
262_L 290_V 1.088 0.67
81_I 181_I 1.085 0.66
245_Y 324_F 1.085 0.66
37_R 40_F 1.084 0.66
84_S 88_V 1.081 0.66
153_G 218_N 1.081 0.66
317_V 324_F 1.081 0.66
14_V 23_L 1.08 0.66
152_G 159_A 1.079 0.66
168_F 222_S 1.077 0.66
15_I 30_F 1.074 0.65
20_C 28_F 1.074 0.65
243_L 288_I 1.07 0.65
149_G 158_M 1.063 0.64
218_N 245_Y 1.063 0.64
52_I 107_K 1.06 0.64
278_F 311_L 1.06 0.64
173_L 245_Y 1.054 0.63
20_C 29_W 1.047 0.62
153_G 176_D 1.044 0.62
18_G 31_R 1.042 0.62
184_W 299_W 1.042 0.62
16_I 20_C 1.042 0.62
113_T 172_M 1.042 0.62
267_A 301_E 1.041 0.62
240_T 289_M 1.038 0.61
194_G 206_I 1.036 0.61
17_F 37_R 1.035 0.61
260_E 263_K 1.035 0.61
245_Y 283_D 1.034 0.61
14_V 17_F 1.031 0.61
146_L 155_A 1.03 0.61
197_A 213_P 1.03 0.61
331_L 335_N 1.027 0.60
198_E 205_K 1.026 0.60
113_T 231_R 1.025 0.60
24_I 41_L 1.023 0.60
243_L 317_V 1.023 0.60
82_C 96_L 1.019 0.59
112_I 132_L 1.017 0.59
257_A 316_I 1.015 0.59
166_N 217_P 1.014 0.59
15_I 21_A 1.014 0.59
82_C 161_K 1.013 0.59
25_L 32_R 1.012 0.59
140_M 144_G 1.01 0.58
80_F 92_I 1.008 0.58
117_I 157_G 1.004 0.58
169_S 255_V 1.002 0.57
78_I 96_L 1.002 0.57
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2vv5A70.8281000.375Contact Map0.569
4hw9A70.86591000.379Contact Map0.527
3udcA70.79591000.411Contact Map0.509
2lt1A10.186635.20.961Contact Map0.393
3mlqE40.183731.40.962Contact Map0.652
1nz9A10.145828.40.963Contact Map0.453
2e6zA10.154526.30.964Contact Map0.6
4l5gA20.396524.70.964Contact Map0.343
2lt4A10.180821.30.965Contact Map0.386
4kbmB10.393618.20.966Contact Map0.402
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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