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OPENSEQ.org
FRDB - Fumarate reductase iron-sulfur subunit
UniProt: P0AC47 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10331
Length: 244 (233)
Sequences: 1376
Seq/Len: 5.91
FRDB
Paralog alert: 0.40 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DHSB FRDB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
8_K 28_E 4.037 1.00
43_Y 47_N 3.561 1.00
42_G 54_Y 3.456 1.00
6_N 30_P 3.248 1.00
9_I 40_A 3.035 1.00
25_A 49_A 2.858 1.00
118_K 122_I 2.84 1.00
10_E 90_K 2.753 1.00
10_E 26_F 2.716 1.00
53_S 104_V 2.582 1.00
15_N 18_V 2.442 1.00
110_F 153_G 2.391 1.00
40_A 82_L 2.206 1.00
68_M 77_A 2.077 1.00
118_K 191_E 2.041 1.00
74_P 158_A 2.022 1.00
122_I 188_G 2.012 1.00
6_N 28_E 1.95 1.00
9_I 44_I 1.924 1.00
123_G 187_H 1.879 1.00
174_I 196_L 1.835 1.00
29_V 44_I 1.811 1.00
174_I 228_G 1.723 1.00
75_K 80_T 1.705 1.00
146_F 224_A 1.701 1.00
41_L 68_M 1.685 1.00
137_P 141_A 1.643 1.00
124_N 187_H 1.584 0.99
37_L 70_V 1.557 0.99
178_H 182_E 1.548 0.99
123_G 133_N 1.545 0.99
209_G 221_P 1.527 0.99
8_K 26_F 1.519 0.99
160_P 208_V 1.517 0.99
129_D 132_T 1.452 0.99
125_S 187_H 1.451 0.99
139_Q 184_S 1.435 0.99
196_L 199_Q 1.43 0.98
15_N 23_H 1.429 0.98
35_T 43_Y 1.403 0.98
195_Q 201_G 1.397 0.98
190_K 194_A 1.389 0.98
175_T 219_V 1.38 0.98
30_P 43_Y 1.321 0.97
168_F 182_E 1.321 0.97
212_S 222_A 1.321 0.97
42_G 46_D 1.317 0.97
170_G 224_A 1.314 0.97
113_S 196_L 1.312 0.97
11_V 52_L 1.3 0.97
135_Q 184_S 1.288 0.96
142_K 227_Q 1.267 0.96
110_F 156_Y 1.248 0.96
234_K 237_L 1.243 0.95
67_G 116_A 1.238 0.95
70_V 75_K 1.229 0.95
169_I 173_A 1.224 0.95
10_E 24_S 1.208 0.94
15_N 19_D 1.197 0.94
20_T 23_H 1.192 0.94
62_I 79_K 1.19 0.94
7_L 40_A 1.189 0.94
43_Y 48_L 1.186 0.94
29_V 40_A 1.18 0.93
15_N 20_T 1.171 0.93
110_F 173_A 1.162 0.93
52_L 103_L 1.16 0.93
175_T 224_A 1.134 0.92
55_R 65_S 1.133 0.92
18_V 101_R 1.125 0.91
85_Y 89_M 1.124 0.91
17_E 20_T 1.118 0.91
210_Y 214_V 1.118 0.91
29_V 43_Y 1.116 0.91
113_S 200_N 1.114 0.91
9_I 89_M 1.108 0.90
212_S 220_D 1.103 0.90
37_L 82_L 1.098 0.90
92_E 214_V 1.09 0.89
205_C 211_C 1.08 0.89
127_T 130_Q 1.076 0.89
12_V 92_E 1.076 0.89
194_A 197_N 1.071 0.88
73_V 191_E 1.068 0.88
31_Y 40_A 1.06 0.88
31_Y 82_L 1.058 0.87
97_F 107_M 1.056 0.87
12_V 22_P 1.054 0.87
112_E 115_E 1.05 0.87
147_S 153_G 1.035 0.86
137_P 168_F 1.034 0.86
23_H 27_Y 1.033 0.86
70_V 77_A 1.029 0.85
12_V 24_S 1.029 0.85
24_S 92_E 1.024 0.85
74_P 210_Y 1.023 0.85
118_K 195_Q 1.021 0.85
66_C 96_N 1.014 0.84
69_M 208_V 1.006 0.84
29_V 52_L 1.002 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kwlA10.84021000.394Contact Map0.578
1kf6B20.99591000.429Contact Map0.675
3vr8B211000.438Contact Map0.674
2h88B20.98361000.445Contact Map0.687
2wdqB30.95081000.456Contact Map0.67
2bs2B20.96721000.476Contact Map0.671
3i9v320.840299.90.755Contact Map0.397
3c8yA10.856699.90.756Contact Map0.351
1ffvA20.659899.80.766Contact Map0.571
1t3qA20.659899.80.78Contact Map0.527
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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