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OPENSEQ.org
FRLB - Fructoselysine 6-phosphate deglycase
UniProt: P0AC00 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12909
Length: 340 (309)
Sequences: 2411
Seq/Len: 7.80
FRLB
Paralog alert: 0.40 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: AGAS FRLB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_D 93_R 5.06 1.00
124_A 137_A 3.78 1.00
113_E 136_A 3.659 1.00
49_F 59_A 3.533 1.00
188_G 192_R 3.238 1.00
195_E 319_Y 3.097 1.00
98_G 112_L 2.551 1.00
59_A 99_V 2.54 1.00
189_H 192_R 2.516 1.00
46_R 75_Y 2.29 1.00
187_L 311_V 2.273 1.00
45_D 91_D 2.233 1.00
244_S 274_T 2.221 1.00
44_I 95_A 2.199 1.00
116_R 138_E 2.196 1.00
172_E 175_K 2.189 1.00
143_Y 151_I 2.141 1.00
114_L 117_A 2.125 1.00
228_I 239_G 2.11 1.00
95_A 123_A 2.073 1.00
206_S 323_Y 2.058 1.00
99_V 156_C 1.973 1.00
322_I 328_P 1.937 1.00
149_W 222_L 1.937 1.00
225_K 241_V 1.903 1.00
196_E 199_R 1.903 1.00
227_G 313_M 1.886 1.00
203_E 323_Y 1.865 1.00
96_V 115_G 1.841 1.00
100_S 133_I 1.836 1.00
204_L 287_N 1.829 1.00
66_A 74_V 1.786 1.00
297_S 309_M 1.777 1.00
66_A 163_M 1.776 1.00
47_I 97_I 1.775 1.00
161_L 176_I 1.772 1.00
78_S 243_E 1.763 1.00
112_L 133_I 1.735 1.00
96_V 120_A 1.724 1.00
268_D 302_P 1.698 1.00
292_D 296_I 1.674 1.00
183_L 307_F 1.673 1.00
66_A 160_V 1.664 1.00
193_T 197_K 1.635 1.00
49_F 74_V 1.63 1.00
68_R 87_P 1.626 1.00
126_T 134_T 1.583 1.00
263_F 278_I 1.568 1.00
91_D 94_C 1.55 1.00
56_L 60_Q 1.545 1.00
129_A 142_D 1.542 1.00
265_L 278_I 1.532 1.00
124_A 133_I 1.529 1.00
47_I 95_A 1.523 1.00
179_D 301_H 1.52 1.00
291_I 297_S 1.517 1.00
71_D 89_R 1.512 1.00
90_L 120_A 1.504 0.99
63_K 67_D 1.5 0.99
220_R 225_K 1.492 0.99
124_A 140_S 1.47 0.99
319_Y 323_Y 1.47 0.99
182_Q 185_N 1.459 0.99
185_N 188_G 1.457 0.99
134_T 140_S 1.457 0.99
179_D 186_A 1.455 0.99
122_T 137_A 1.443 0.99
222_L 310_F 1.443 0.99
44_I 94_C 1.441 0.99
232_M 240_C 1.427 0.99
186_A 300_L 1.415 0.99
169_P 172_E 1.41 0.99
182_Q 186_A 1.41 0.99
281_V 288_V 1.407 0.99
200_Q 203_E 1.391 0.99
48_Y 94_C 1.386 0.99
186_A 308_L 1.365 0.99
82_F 90_L 1.351 0.99
106_E 110_K 1.343 0.99
197_K 200_Q 1.335 0.99
209_P 324_K 1.335 0.99
49_F 97_I 1.327 0.98
190_L 308_L 1.323 0.98
50_V 96_V 1.311 0.98
98_G 122_T 1.31 0.98
248_R 280_F 1.297 0.98
46_R 73_Q 1.291 0.98
209_P 256_E 1.283 0.98
178_N 182_Q 1.258 0.98
227_G 264_L 1.242 0.97
71_D 87_P 1.239 0.97
121_L 138_E 1.234 0.97
125_F 159_V 1.221 0.97
77_I 85_N 1.214 0.97
183_L 308_L 1.212 0.97
262_L 316_L 1.197 0.97
113_E 117_A 1.196 0.96
269_E 302_P 1.196 0.96
226_E 230_T 1.191 0.96
47_I 72_L 1.188 0.96
114_L 118_C 1.175 0.96
175_K 301_H 1.173 0.96
46_R 94_C 1.169 0.96
205_A 316_L 1.158 0.96
264_L 313_M 1.151 0.95
315_W 319_Y 1.147 0.95
123_A 141_I 1.138 0.95
125_F 156_C 1.131 0.95
97_I 159_V 1.128 0.95
63_K 75_Y 1.123 0.94
209_P 258_G 1.122 0.94
316_L 320_L 1.122 0.94
65_L 157_Y 1.118 0.94
134_T 142_D 1.116 0.94
161_L 173_I 1.116 0.94
104_K 132_P 1.103 0.94
176_I 179_D 1.099 0.94
171_A 175_K 1.096 0.94
213_T 231_L 1.09 0.93
214_V 263_F 1.084 0.93
271_R 275_E 1.083 0.93
143_Y 152_H 1.077 0.93
199_R 203_E 1.077 0.93
199_R 319_Y 1.073 0.93
265_L 271_R 1.068 0.92
179_D 182_Q 1.067 0.92
121_L 139_F 1.067 0.92
279_N 282_K 1.066 0.92
62_A 156_C 1.065 0.92
165_T 173_I 1.06 0.92
46_R 91_D 1.059 0.92
94_C 120_A 1.056 0.92
174_G 178_N 1.055 0.92
52_C 79_G 1.054 0.92
177_K 181_K 1.05 0.91
219_L 264_L 1.042 0.91
170_N 174_G 1.041 0.91
130_D 134_T 1.038 0.91
51_A 76_A 1.031 0.90
236_W 332_R 1.03 0.90
282_K 295_E 1.019 0.90
161_L 164_I 1.019 0.90
175_K 179_D 1.019 0.90
29_V 33_H 1.017 0.90
300_L 308_L 1.016 0.90
168_A 173_I 1.01 0.89
230_T 253_E 1.005 0.89
110_K 113_E 1.004 0.89
141_I 155_L 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2a3nA10.96761000.266Contact Map0.686
2zj3A10.97351000.282Contact Map0.8
1moqA10.97651000.285Contact Map0.73
2pocA40.96181000.286Contact Map0.838
3tbfA80.97351000.291Contact Map0.82
3euaA80.93821000.295Contact Map0.708
3fkjA20.97651000.297Contact Map0.698
2bplA30.97351000.299Contact Map0.802
3fj1A40.95591000.309Contact Map0.671
3knzA60.98241000.31Contact Map0.787
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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