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OPENSEQ.org
MTR - Tryptophan-specific transport protein
UniProt: P0AAD2 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10617
Length: 414 (405)
Sequences: 420
Seq/Len: 1.04
MTR
Paralog alert: 0.83 [within 20: 0.05] - ratio of genomes with paralogs
Cluster includes: MTR TNAB TYRP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
45_M 241_T 2.415 0.99
15_G 150_S 2.413 0.99
386_P 390_L 2.123 0.97
41_F 180_L 1.858 0.93
327_L 331_A 1.823 0.92
310_A 325_T 1.823 0.92
159_A 230_V 1.767 0.90
184_A 414_Q 1.722 0.89
104_Y 343_G 1.695 0.88
59_G 233_T 1.693 0.88
206_G 301_V 1.676 0.87
150_S 154_A 1.672 0.87
126_P 129_A 1.669 0.87
103_T 302_T 1.667 0.87
209_G 304_G 1.619 0.85
150_S 217_Y 1.602 0.84
15_G 217_Y 1.584 0.83
102_L 206_G 1.581 0.83
92_G 308_Y 1.576 0.82
69_Y 81_D 1.575 0.82
371_R 383_G 1.575 0.82
98_V 236_A 1.567 0.82
23_T 31_S 1.556 0.81
111_G 130_A 1.542 0.80
404_L 407_F 1.533 0.80
31_S 200_F 1.499 0.78
58_S 355_A 1.489 0.77
371_R 384_G 1.469 0.76
209_G 359_A 1.468 0.76
381_V 384_G 1.464 0.75
210_N 359_A 1.449 0.74
64_E 371_R 1.448 0.74
79_T 87_W 1.442 0.74
14_L 132_F 1.413 0.72
114_L 245_L 1.41 0.71
245_L 255_E 1.394 0.70
109_A 294_V 1.379 0.69
213_S 307_D 1.372 0.68
301_V 330_F 1.371 0.68
38_G 304_G 1.37 0.68
236_A 348_I 1.364 0.68
24_I 160_K 1.361 0.67
206_G 351_A 1.359 0.67
21_G 235_M 1.357 0.67
238_A 396_V 1.355 0.67
343_G 349_G 1.347 0.66
93_I 403_I 1.337 0.65
97_F 341_P 1.33 0.65
94_S 338_L 1.321 0.64
146_T 217_Y 1.314 0.63
102_L 207_Y 1.307 0.63
171_L 360_A 1.3 0.62
307_D 310_A 1.294 0.62
133_G 327_L 1.29 0.61
60_L 226_V 1.287 0.61
31_S 305_L 1.279 0.60
46_A 49_I 1.276 0.60
126_P 327_L 1.271 0.60
328_L 404_L 1.267 0.59
238_A 385_K 1.266 0.59
82_L 366_L 1.263 0.59
59_G 212_P 1.263 0.59
104_Y 349_G 1.262 0.59
404_L 409_L 1.259 0.59
15_G 154_A 1.258 0.59
108_S 131_G 1.257 0.58
19_I 146_T 1.256 0.58
227_K 381_V 1.253 0.58
102_L 304_G 1.235 0.56
63_L 77_T 1.225 0.55
323_L 386_P 1.224 0.55
146_T 303_L 1.218 0.55
297_S 344_F 1.217 0.55
23_T 72_G 1.216 0.55
162_I 219_G 1.214 0.54
15_G 146_T 1.214 0.54
49_I 372_K 1.214 0.54
301_V 359_A 1.212 0.54
77_T 311_D 1.207 0.54
270_V 294_V 1.2 0.53
56_L 229_L 1.198 0.53
310_A 321_G 1.196 0.53
25_I 207_Y 1.196 0.53
22_G 52_W 1.193 0.52
97_F 304_G 1.19 0.52
19_I 210_N 1.179 0.51
55_M 97_F 1.179 0.51
238_A 400_L 1.175 0.51
369_A 373_R 1.174 0.51
108_S 347_A 1.171 0.50
210_N 304_G 1.169 0.50
122_S 273_L 1.164 0.50
369_A 372_K 1.161 0.49
372_K 385_K 1.16 0.49
133_G 223_K 1.158 0.49
78_I 290_S 1.157 0.49
27_A 384_G 1.156 0.49
142_V 234_L 1.155 0.49
355_A 359_A 1.153 0.49
178_A 251_I 1.152 0.49
21_G 27_A 1.149 0.48
221_D 357_I 1.148 0.48
31_S 52_W 1.145 0.48
167_T 292_F 1.144 0.48
56_L 234_L 1.142 0.48
31_S 110_S 1.141 0.48
16_G 34_V 1.139 0.47
36_M 110_S 1.136 0.47
153_T 358_W 1.134 0.47
254_P 377_P 1.128 0.46
136_L 335_V 1.125 0.46
75_F 145_S 1.118 0.45
405_S 414_Q 1.117 0.45
15_G 19_I 1.115 0.45
185_E 188_A 1.111 0.45
32_L 82_L 1.104 0.44
353_L 361_I 1.103 0.44
49_I 114_L 1.1 0.44
199_P 293_A 1.093 0.43
83_L 365_L 1.093 0.43
386_P 389_A 1.092 0.43
22_G 26_G 1.091 0.43
105_A 333_P 1.091 0.43
58_S 348_I 1.091 0.43
71_I 397_G 1.09 0.43
218_Y 296_S 1.09 0.43
59_G 164_F 1.09 0.43
208_H 293_A 1.085 0.42
91_N 362_V 1.085 0.42
76_D 229_L 1.083 0.42
309_L 360_A 1.079 0.42
20_I 328_L 1.078 0.42
92_G 103_T 1.078 0.42
97_F 354_A 1.077 0.42
294_V 337_G 1.077 0.42
48_L 270_V 1.075 0.42
109_A 156_V 1.075 0.42
40_W 104_Y 1.074 0.41
125_V 221_D 1.073 0.41
171_L 273_L 1.073 0.41
50_F 198_L 1.071 0.41
100_Y 332_P 1.069 0.41
158_G 390_L 1.068 0.41
95_I 266_I 1.065 0.41
238_A 389_A 1.065 0.41
155_I 292_F 1.063 0.40
404_L 410_L 1.062 0.40
405_S 412_V 1.057 0.40
371_R 381_V 1.056 0.40
177_P 331_A 1.055 0.40
141_V 187_N 1.054 0.40
138_V 147_K 1.054 0.40
160_K 236_A 1.053 0.40
354_A 359_A 1.051 0.39
27_A 93_I 1.049 0.39
165_F 176_Q 1.048 0.39
40_W 98_V 1.046 0.39
404_L 411_P 1.045 0.39
61_M 367_A 1.044 0.39
238_A 393_V 1.044 0.39
240_Y 301_V 1.043 0.39
115_H 125_V 1.043 0.39
61_M 388_I 1.043 0.39
379_F 395_G 1.043 0.39
110_S 150_S 1.042 0.39
367_A 371_R 1.041 0.38
352_G 357_I 1.04 0.38
132_F 175_V 1.04 0.38
132_F 159_A 1.039 0.38
76_D 153_T 1.039 0.38
206_G 240_Y 1.038 0.38
135_A 220_K 1.038 0.38
384_G 388_I 1.037 0.38
29_M 206_G 1.037 0.38
207_Y 230_V 1.035 0.38
200_F 345_L 1.034 0.38
188_A 414_Q 1.034 0.38
139_A 326_A 1.034 0.38
66_N 74_S 1.034 0.38
61_M 381_V 1.033 0.38
88_N 356_T 1.033 0.38
22_G 28_G 1.032 0.38
269_L 272_A 1.031 0.38
185_E 414_Q 1.03 0.37
405_S 410_L 1.029 0.37
45_M 361_I 1.026 0.37
87_W 145_S 1.025 0.37
399_A 402_H 1.024 0.37
52_W 96_A 1.024 0.37
138_V 246_A 1.024 0.37
184_A 405_S 1.022 0.37
65_A 78_I 1.021 0.37
15_G 98_V 1.021 0.37
159_A 235_M 1.02 0.37
157_L 247_T 1.018 0.36
125_V 129_A 1.018 0.36
256_F 259_I 1.018 0.36
32_L 66_N 1.018 0.36
217_Y 330_F 1.017 0.36
331_A 335_V 1.017 0.36
361_I 392_L 1.014 0.36
306_F 325_T 1.013 0.36
357_I 400_L 1.011 0.36
41_F 347_A 1.009 0.36
27_A 105_A 1.008 0.36
378_K 403_I 1.008 0.36
223_K 227_K 1.004 0.35
66_N 72_G 1.003 0.35
55_M 100_Y 1.001 0.35
32_L 74_S 1 0.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.97341000.772Contact Map0.206
4djkA20.968699.90.806Contact Map0.161
3giaA10.94299.90.806Contact Map0.188
2jlnA10.9034980.925Contact Map0.158
3dh4A40.944497.40.935Contact Map0.182
2xq2A10.951796.80.94Contact Map0.189
2a65A10.958996.10.944Contact Map0.184
4m48A10.958991.90.954Contact Map0.131
2gfpA20.620826.50.973Contact Map0.115
3qrxB10.05819.10.975Contact Map0.349
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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