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OPENSEQ.org
SERA - D-3-phosphoglycerate dehydrogenase
UniProt: P0A9T0 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10944
Length: 410 (399)
Sequences: 2087
Seq/Len: 5.23
SERA
Paralog alert: 0.34 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: GHRA GHRB LDHD SERA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
245_D 248_A 5.634 1.00
222_G 225_E 4.796 1.00
231_P 257_H 4.293 1.00
223_A 251_D 4.134 1.00
198_S 228_L 4.092 1.00
196_H 199_D 3.452 1.00
233_S 258_L 3.199 1.00
219_N 267_P 3.185 1.00
70_I 79_I 3.006 1.00
221_M 226_I 2.867 1.00
67_E 71_N 2.8 1.00
254_A 284_F 2.767 1.00
154_L 170_A 2.718 1.00
124_L 206_V 2.692 1.00
153_K 176_Y 2.691 1.00
44_D 68_D 2.69 1.00
117_I 173_L 2.612 1.00
67_E 96_K 2.6 1.00
155_G 200_L 2.567 1.00
226_I 235_L 2.478 1.00
209_L 243_V 2.442 1.00
213_E 218_K 2.324 1.00
202_N 228_L 2.316 1.00
153_K 178_Y 2.244 1.00
36_E 54_A 2.236 1.00
21_Q 25_E 2.233 1.00
200_L 204_S 2.201 1.00
232_G 258_L 2.106 1.00
57_I 65_L 2.092 1.00
251_D 255_S 2.087 1.00
123_L 260_G 2.083 1.00
178_Y 203_M 2.067 1.00
44_D 66_T 2.049 1.00
154_L 175_M 2.039 1.00
227_S 257_H 2.021 1.00
199_D 203_M 2.019 1.00
223_A 227_S 2.01 1.00
226_I 252_A 2.008 1.00
166_L 208_S 1.992 1.00
207_V 233_S 1.947 1.00
155_G 204_S 1.897 1.00
234_L 259_A 1.876 1.00
115_L 294_G 1.854 1.00
221_M 235_L 1.847 1.00
43_D 46_Q 1.834 1.00
12_K 34_N 1.831 1.00
48_K 68_D 1.83 1.00
219_N 245_D 1.829 1.00
226_I 229_M 1.828 1.00
250_C 284_F 1.81 1.00
176_Y 192_T 1.806 1.00
152_K 299_E 1.788 1.00
117_I 170_A 1.788 1.00
192_T 203_M 1.786 1.00
25_E 29_A 1.784 1.00
194_V 200_L 1.775 1.00
94_A 101_V 1.744 1.00
201_L 225_E 1.739 1.00
70_I 99_I 1.706 1.00
48_K 72_A 1.682 1.00
175_M 206_V 1.677 1.00
178_Y 204_S 1.674 0.99
224_K 228_L 1.662 0.99
14_L 54_A 1.659 0.99
254_A 283_E 1.651 0.99
95_A 326_N 1.647 0.99
253_L 287_V 1.64 0.99
198_S 202_N 1.638 0.99
131_N 135_H 1.616 0.99
250_C 254_A 1.613 0.99
221_M 225_E 1.608 0.99
93_A 96_K 1.578 0.99
201_L 221_M 1.566 0.99
44_D 48_K 1.542 0.99
215_P 218_K 1.534 0.99
284_F 287_V 1.531 0.99
92_D 96_K 1.512 0.99
45_E 68_D 1.497 0.99
71_N 97_R 1.47 0.98
223_A 248_A 1.461 0.98
126_G 129_E 1.45 0.98
213_E 242_T 1.442 0.98
229_M 233_S 1.436 0.98
212_P 217_T 1.428 0.98
56_F 312_L 1.396 0.98
180_Y 197_L 1.394 0.98
360_E 396_A 1.371 0.97
249_L 261_A 1.365 0.97
153_K 204_S 1.362 0.97
195_Q 199_D 1.36 0.97
71_N 93_A 1.349 0.97
70_I 97_R 1.345 0.97
395_Q 399_A 1.34 0.97
80_G 308_V 1.334 0.97
53_D 75_K 1.333 0.97
205_D 230_K 1.328 0.96
123_L 234_L 1.321 0.96
220_M 243_V 1.312 0.96
116_V 166_L 1.309 0.96
247_P 280_P 1.307 0.96
89_V 101_V 1.306 0.96
252_A 258_L 1.304 0.96
48_K 69_V 1.303 0.96
235_L 244_V 1.299 0.96
157_I 207_V 1.294 0.96
366_A 384_E 1.293 0.96
123_L 288_L 1.286 0.95
36_E 50_S 1.268 0.95
157_I 209_L 1.267 0.95
56_F 78_A 1.267 0.95
156_I 167_G 1.266 0.95
234_L 260_G 1.262 0.95
232_G 257_H 1.261 0.95
170_A 175_M 1.261 0.95
226_I 257_H 1.26 0.95
232_G 255_S 1.251 0.95
81_C 89_V 1.247 0.94
253_L 286_N 1.243 0.94
51_I 74_E 1.243 0.94
159_Y 179_F 1.227 0.94
249_L 258_L 1.225 0.94
198_S 225_E 1.218 0.93
178_Y 194_V 1.216 0.93
74_E 97_R 1.216 0.93
313_I 317_D 1.209 0.93
353_A 400_I 1.209 0.93
361_Q 396_A 1.198 0.93
123_L 262_A 1.195 0.93
176_Y 203_M 1.191 0.92
222_G 245_D 1.19 0.92
55_H 77_V 1.187 0.92
314_K 319_G 1.184 0.92
156_I 208_S 1.184 0.92
201_L 233_S 1.184 0.92
227_S 255_S 1.184 0.92
108_N 295_G 1.182 0.92
314_K 322_L 1.181 0.92
150_R 174_G 1.177 0.92
59_L 89_V 1.177 0.92
209_L 235_L 1.175 0.92
235_L 258_L 1.163 0.91
254_A 286_N 1.161 0.91
46_Q 49_E 1.158 0.91
91_L 95_A 1.143 0.90
116_V 238_A 1.14 0.90
222_G 248_A 1.12 0.89
352_T 359_A 1.104 0.88
254_A 280_P 1.1 0.88
247_P 251_D 1.091 0.87
32_Y 313_I 1.078 0.86
22_K 302_E 1.077 0.86
201_L 229_M 1.072 0.86
89_V 94_A 1.07 0.86
100_P 324_A 1.066 0.86
120_L 206_V 1.065 0.86
233_S 252_A 1.054 0.85
208_S 238_A 1.049 0.84
225_E 229_M 1.042 0.84
121_L 173_L 1.039 0.84
44_D 69_V 1.028 0.83
233_S 257_H 1.023 0.82
122_L 128_P 1.022 0.82
67_E 93_A 1.021 0.82
234_L 262_A 1.018 0.82
340_L 381_I 1.015 0.82
78_A 315_Y 1.015 0.82
116_V 236_I 1.015 0.82
132_A 136_R 1.013 0.81
115_L 119_E 1.011 0.81
315_Y 321_T 1.007 0.81
67_E 90_D 1.006 0.81
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3k5pA10.99511000.203Contact Map0.773
1sc6A40.98541000.217Contact Map0.774
1ygyA20.95851000.355Contact Map0.729
2g76A20.77071000.453Contact Map0.765
3ba1A10.77561000.462Contact Map0.716
4dgsA10.77561000.463Contact Map0.696
1dxyA10.77321000.463Contact Map0.72
4lswA10.76831000.463Contact Map0.653
1xdwA10.76831000.464Contact Map0.71
2w2kA10.78291000.465Contact Map0.703
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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