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OPENSEQ.org
MURA - UDP-N-acetylglucosamine 1-carboxyvinyltransferase
UniProt: P0A749 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11358
Length: 419 (417)
Sequences: 3782
Seq/Len: 9.07
MURA
Paralog alert: 0.88 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: AROA MURA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
344_H 355_H 3.737 1.00
15_E 252_R 3.696 1.00
248_K 281_S 3.643 1.00
42_Q 225_V 3.348 1.00
179_T 216_E 3.303 1.00
401_R 404_D 3.214 1.00
7_Q 412_N 3.155 1.00
198_L 203_A 3.138 1.00
250_I 281_S 3.11 1.00
36_E 220_R 3.083 1.00
244_I 378_L 2.939 1.00
204_K 216_E 2.868 1.00
17_T 252_R 2.816 1.00
38_P 73_D 2.656 1.00
42_Q 227_R 2.609 1.00
399_Y 405_K 2.602 1.00
243_A 271_A 2.564 1.00
248_K 283_D 2.473 1.00
150_R 177_E 2.463 1.00
320_T 355_H 2.45 1.00
155_H 183_E 2.447 1.00
337_E 340_R 2.429 1.00
112_P 118_G 2.413 1.00
46_K 51_D 2.402 1.00
288_R 318_E 2.371 1.00
366_M 390_D 2.351 1.00
55_K 58_S 2.35 1.00
162_S 165_A 2.336 1.00
249_I 409_L 2.274 1.00
128_G 169_I 2.271 1.00
380_G 387_T 2.229 1.00
359_K 384_E 2.225 1.00
272_D 283_D 2.197 1.00
240_V 313_L 2.185 1.00
179_T 214_V 2.116 1.00
40_E 225_V 2.104 1.00
65_E 71_H 2.103 1.00
364_Q 388_V 2.088 1.00
290_K 318_E 2.083 1.00
276_G 279_W 2.019 1.00
25_A 44_V 2.007 1.00
396_D 415_R 1.971 1.00
10_T 412_N 1.968 1.00
170_M 195_A 1.955 1.00
364_Q 390_D 1.952 1.00
320_T 353_I 1.845 1.00
30_F 53_S 1.835 1.00
38_P 71_H 1.834 1.00
348_E 351_T 1.825 1.00
42_Q 69_S 1.818 1.00
157_V 183_E 1.818 1.00
155_H 181_I 1.805 1.00
293_N 324_T 1.802 1.00
106_Q 146_S 1.79 1.00
40_E 71_H 1.784 1.00
337_E 376_L 1.781 1.00
291_A 321_G 1.78 1.00
322_F 353_I 1.753 1.00
13_Q 248_K 1.749 1.00
346_E 353_I 1.736 1.00
40_E 69_S 1.712 1.00
316_V 382_I 1.703 1.00
108_Q 144_K 1.694 1.00
58_S 63_K 1.685 1.00
152_K 177_E 1.662 1.00
16_V 409_L 1.659 1.00
250_I 279_W 1.626 1.00
203_A 221_L 1.624 1.00
208_Q 213_I 1.616 1.00
58_S 64_V 1.609 1.00
312_L 375_S 1.593 1.00
28_I 197_F 1.588 1.00
291_A 320_T 1.579 1.00
199_I 208_Q 1.577 1.00
250_I 276_G 1.575 1.00
63_K 73_D 1.571 1.00
144_K 147_V 1.567 1.00
32_A 39_V 1.558 1.00
153_G 176_A 1.553 1.00
338_L 343_A 1.55 1.00
95_W 167_V 1.549 1.00
62_A 72_I 1.541 1.00
264_A 267_R 1.526 1.00
123_D 127_S 1.525 1.00
335_V 345_A 1.522 1.00
235_T 254_A 1.489 1.00
127_S 131_Q 1.479 1.00
239_L 263_L 1.478 1.00
158_M 169_I 1.475 1.00
337_E 368_T 1.473 1.00
99_P 168_T 1.469 1.00
130_E 135_T 1.468 1.00
41_I 228_V 1.467 1.00
199_I 204_K 1.454 1.00
236_G 306_M 1.452 1.00
377_V 402_I 1.45 1.00
346_E 355_H 1.447 1.00
341_M 363_A 1.432 0.99
37_E 223_G 1.43 0.99
46_K 66_R 1.427 0.99
274_E 281_S 1.426 0.99
319_G 356_G 1.424 0.99
274_E 283_D 1.421 0.99
25_A 50_V 1.417 0.99
314_N 321_G 1.407 0.99
365_V 376_L 1.402 0.99
341_M 387_T 1.401 0.99
229_L 258_T 1.394 0.99
35_A 39_V 1.39 0.99
177_E 219_E 1.375 0.99
240_V 262_V 1.36 0.99
88_K 91_R 1.357 0.99
293_N 322_F 1.356 0.99
28_I 228_V 1.347 0.99
15_E 250_I 1.345 0.99
239_L 266_L 1.334 0.99
182_I 185_A 1.333 0.99
5_R 414_E 1.328 0.99
135_T 148_D 1.305 0.99
5_R 388_V 1.301 0.99
239_L 251_C 1.294 0.99
5_R 416_V 1.287 0.99
201_L 224_G 1.283 0.99
7_Q 386_T 1.275 0.98
341_M 379_A 1.27 0.98
135_T 146_S 1.268 0.98
54_M 70_V 1.268 0.98
29_L 54_M 1.267 0.98
206_S 216_E 1.263 0.98
380_G 389_V 1.254 0.98
170_M 215_I 1.254 0.98
137_K 146_S 1.253 0.98
127_S 130_E 1.253 0.98
116_T 119_A 1.249 0.98
199_I 205_I 1.229 0.98
28_I 41_I 1.229 0.98
330_N 333_M 1.222 0.98
18_I 251_C 1.222 0.98
29_L 57_L 1.206 0.98
407_R 414_E 1.204 0.98
91_R 95_W 1.199 0.97
193_D 226_Y 1.199 0.97
269_A 317_A 1.191 0.97
315_L 343_A 1.191 0.97
373_S 395_I 1.184 0.97
345_A 352_V 1.184 0.97
366_M 391_R 1.183 0.97
239_L 242_A 1.179 0.97
26_L 53_S 1.178 0.97
269_A 292_V 1.177 0.97
311_T 323_I 1.176 0.97
296_T 325_E 1.172 0.97
241_A 378_L 1.168 0.97
314_N 323_I 1.159 0.97
312_L 379_A 1.154 0.97
27_P 30_F 1.152 0.97
226_Y 229_L 1.148 0.96
255_Q 258_T 1.148 0.96
44_V 50_V 1.146 0.96
54_M 64_V 1.143 0.96
311_T 334_H 1.143 0.96
335_V 352_V 1.14 0.96
151_L 176_A 1.137 0.96
241_A 381_C 1.137 0.96
190_E 232_R 1.129 0.96
316_V 357_V 1.127 0.96
134_A 151_L 1.121 0.96
343_A 360_L 1.12 0.96
404_D 407_R 1.118 0.96
197_F 224_G 1.115 0.96
87_V 91_R 1.113 0.96
291_A 317_A 1.105 0.95
240_V 306_M 1.098 0.95
200_T 224_G 1.095 0.95
267_R 272_D 1.091 0.95
406_L 411_A 1.086 0.95
37_E 74_A 1.081 0.95
126_I 130_E 1.079 0.95
348_E 353_I 1.075 0.94
291_A 318_E 1.07 0.94
267_R 275_V 1.067 0.94
199_I 206_S 1.064 0.94
176_A 180_T 1.063 0.94
187_R 211_D 1.062 0.94
62_A 74_A 1.062 0.94
132_L 154_A 1.06 0.94
238_F 399_Y 1.059 0.94
183_E 212_R 1.059 0.94
178_G 217_G 1.057 0.94
7_Q 10_T 1.053 0.94
99_P 102_A 1.052 0.93
383_A 387_T 1.052 0.93
373_S 394_H 1.05 0.93
266_L 313_L 1.044 0.93
365_V 387_T 1.043 0.93
266_L 271_A 1.041 0.93
39_V 197_F 1.035 0.93
174_T 203_A 1.034 0.93
5_R 386_T 1.034 0.93
236_G 309_Q 1.033 0.93
52_T 55_K 1.03 0.93
197_F 201_L 1.028 0.92
81_C 108_Q 1.022 0.92
124_L 160_K 1.021 0.92
405_K 408_A 1.021 0.92
167_V 194_T 1.017 0.92
276_G 281_S 1.015 0.92
115_C 370_L 1.012 0.92
37_E 222_G 1.01 0.92
55_K 59_Q 1.008 0.91
244_I 382_I 1.007 0.91
335_V 347_I 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3rmtA40.98091000.099Contact Map0.761
2pqcA10.97611000.122Contact Map0.725
3zh4A10.99521000.141Contact Map0.786
3slhA40.97851000.149Contact Map0.775
4fqdA20.99521000.163Contact Map0.704
3r38A10.99521000.163Contact Map0.789
1rf6A40.95941000.174Contact Map0.748
1ejdA20.99761000.177Contact Map0.779
2yvwA10.99051000.181Contact Map0.784
3nvsA10.96181000.188Contact Map0.733
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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