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OPENSEQ.org
BIOD2 - ATP-dependent dethiobiotin synthetase BioD 2
UniProt: P0A6E9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13849
Length: 231 (220)
Sequences: 1293
Seq/Len: 5.88
BIOD2
Paralog alert: 0.31 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: BIOD1 BIOD2
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
140_M 155_T 3.636 1.00
157_Q 162_D 2.824 1.00
142_V 148_C 2.712 1.00
138_V 159_I 2.672 1.00
156_A 166_L 2.462 1.00
78_S 86_H 2.339 1.00
19_V 170_V 2.3 1.00
150_N 154_L 2.19 1.00
84_V 123_D 2.112 1.00
157_Q 161_N 2.074 1.00
33_T 107_D 2.071 1.00
27_L 108_H 2.045 1.00
79_E 85_A 2.039 1.00
77_L 88_C 2.012 1.00
24_L 34_V 1.969 1.00
143_G 148_C 1.929 1.00
11_D 151_H 1.908 1.00
47_T 50_G 1.851 1.00
79_E 86_H 1.839 1.00
149_I 188_L 1.835 1.00
144_I 171_A 1.801 1.00
148_C 152_A 1.767 1.00
5_F 139_L 1.764 1.00
37_Y 98_G 1.757 1.00
5_F 167_I 1.714 1.00
117_W 159_I 1.699 1.00
122_N 125_R 1.679 1.00
142_V 152_A 1.663 1.00
132_V 162_D 1.649 1.00
8_T 113_G 1.63 1.00
156_A 192_L 1.621 0.99
128_S 162_D 1.595 0.99
20_S 110_V 1.585 0.99
91_N 94_L 1.557 0.99
44_S 76_A 1.544 0.99
138_V 164_L 1.489 0.99
10_T 148_C 1.477 0.99
96_S 134_E 1.444 0.99
7_I 20_S 1.442 0.99
36_G 63_S 1.438 0.99
37_Y 99_L 1.434 0.98
159_I 164_L 1.43 0.98
28_A 34_V 1.422 0.98
46_E 78_S 1.392 0.98
68_P 71_A 1.387 0.98
143_G 151_H 1.385 0.98
144_I 148_C 1.37 0.98
130_W 134_E 1.358 0.98
24_L 110_V 1.357 0.98
11_D 143_G 1.351 0.98
153_L 191_K 1.332 0.97
19_V 200_L 1.311 0.97
118_R 158_A 1.3 0.97
169_W 192_L 1.299 0.97
36_G 59_L 1.297 0.97
6_F 113_G 1.295 0.97
11_D 145_Q 1.293 0.97
141_V 172_N 1.274 0.96
111_V 137_P 1.26 0.96
216_R 220_L 1.26 0.96
92_Y 125_R 1.245 0.95
40_V 121_M 1.244 0.95
149_I 171_A 1.232 0.95
150_N 155_T 1.232 0.95
59_L 62_V 1.223 0.95
145_Q 148_C 1.221 0.95
13_S 54_K 1.211 0.94
74_P 98_G 1.197 0.94
169_W 188_L 1.194 0.94
142_V 171_A 1.19 0.94
118_R 128_S 1.175 0.93
140_M 166_L 1.174 0.93
126_P 191_K 1.169 0.93
71_A 105_K 1.164 0.93
188_L 192_L 1.16 0.93
40_V 95_I 1.156 0.93
8_T 155_T 1.155 0.92
159_I 166_L 1.15 0.92
24_L 36_G 1.137 0.92
27_L 34_V 1.126 0.91
189_G 196_L 1.106 0.90
6_F 131_V 1.102 0.90
42_K 81_E 1.099 0.90
118_R 157_Q 1.097 0.90
194_A 197_I 1.096 0.90
171_A 196_L 1.094 0.90
94_L 98_G 1.093 0.89
111_V 136_L 1.085 0.89
73_N 76_A 1.085 0.89
155_T 158_A 1.083 0.89
149_I 184_I 1.078 0.89
173_R 181_Y 1.067 0.88
119_S 127_L 1.067 0.88
42_K 77_L 1.057 0.87
4_R 136_L 1.053 0.87
117_W 131_V 1.052 0.87
118_R 127_L 1.052 0.87
77_L 89_P 1.05 0.87
93_T 133_Q 1.048 0.87
75_I 90_I 1.037 0.86
142_V 169_W 1.035 0.86
13_S 145_Q 1.033 0.86
47_T 52_R 1.026 0.85
117_W 155_T 1.011 0.84
22_A 198_G 1.009 0.84
183_E 186_D 1.008 0.84
158_A 162_D 1.007 0.84
113_G 127_L 1.005 0.83
119_S 184_I 1.003 0.83
124_L 190_K 1.002 0.83
118_R 162_D 1.001 0.83
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a0gA40.99131000.371Contact Map0.621
2obnA40.78791000.545Contact Map0.429
3fgnA40.93071000.597Contact Map0.736
1byiA10.948199.90.623Contact Map0.717
3of5A20.956799.90.634Contact Map0.73
3zq6A40.969799.90.64Contact Map0.576
1s1mA20.982799.90.651Contact Map0.441
3qxcA10.904899.90.651Contact Map0.69
3ug7A40.978499.90.658Contact Map0.528
3nvaA20.991399.90.68Contact Map0.385
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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