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DNAJ - Chaperone protein DnaJ
UniProt: P08622 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10240
Length: 376 (368)
Sequences: 3066
Seq/Len: 8.33
DNAJ
Paralog alert: 0.29 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: CBPA DNAJ
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
17_E 20_E 4.888 1.00
18_E 60_S 3.659 1.00
146_V 199_K 3.658 1.00
273_M 278_G 3.51 1.00
126_E 253_H 3.307 1.00
336_R 343_E 3.18 1.00
129_V 310_V 3.061 1.00
153_K 195_D 2.967 1.00
163_T 185_H 2.924 1.00
263_L 321_L 2.856 1.00
30_M 36_R 2.841 1.00
279_E 290_K 2.779 1.00
133_T 215_K 2.746 1.00
133_T 213_S 2.698 1.00
159_Q 194_K 2.678 1.00
264_Y 324_R 2.626 1.00
210_K 231_E 2.603 1.00
124_T 251_K 2.513 1.00
127_E 134_K 2.493 1.00
4_Q 49_E 2.482 1.00
334_N 337_Q 2.443 1.00
338_K 342_Q 2.417 1.00
169_Q 180_Q 2.407 1.00
153_K 198_N 2.401 1.00
44_E 48_K 2.348 1.00
281_E 288_R 2.23 1.00
64_A 68_Q 2.21 1.00
336_R 339_Q 2.2 1.00
299_T 329_T 2.198 1.00
261_N 312_S 2.186 1.00
340_L 343_E 2.186 1.00
268_P 328_E 2.174 1.00
302_L 322_L 2.136 1.00
37_N 43_A 2.125 1.00
135_E 211_T 2.097 1.00
263_L 310_V 2.091 1.00
124_T 127_E 2.072 1.00
304_R 320_D 2.06 1.00
16_A 21_I 2.022 1.00
266_E 324_R 1.971 1.00
122_E 251_K 1.965 1.00
6_Y 56_V 1.95 1.00
270_N 273_M 1.949 1.00
297_T 325_V 1.949 1.00
268_P 326_V 1.945 1.00
266_E 326_V 1.923 1.00
6_Y 52_E 1.835 1.00
120_N 249_Q 1.818 1.00
162_P 185_H 1.815 1.00
137_R 209_S 1.808 1.00
279_E 292_K 1.802 1.00
145_D 199_K 1.797 1.00
28_L 50_I 1.791 1.00
13_S 20_E 1.775 1.00
142_E 208_R 1.773 1.00
146_V 153_K 1.759 1.00
65_A 74_F 1.756 1.00
303_F 325_V 1.74 1.00
125_L 263_L 1.739 1.00
222_T 249_Q 1.699 1.00
12_V 21_I 1.689 1.00
273_M 345_Q 1.683 1.00
271_F 275_A 1.672 1.00
65_A 69_Y 1.671 1.00
41_K 44_E 1.669 1.00
222_T 250_V 1.662 1.00
28_L 31_K 1.658 1.00
4_Q 8_E 1.655 1.00
60_S 63_R 1.654 1.00
5_D 8_E 1.646 1.00
127_E 132_V 1.628 1.00
135_E 213_S 1.625 1.00
163_T 184_P 1.625 1.00
220_V 224_D 1.621 1.00
122_E 249_Q 1.611 1.00
19_R 23_K 1.594 1.00
267_V 280_I 1.55 1.00
4_Q 9_I 1.543 1.00
170_V 184_P 1.539 1.00
61_Q 65_A 1.536 1.00
286_D 318_Q 1.535 1.00
61_Q 64_A 1.522 1.00
118_R 247_Q 1.516 1.00
145_D 208_R 1.509 1.00
125_L 310_V 1.499 1.00
152_A 156_T 1.497 1.00
302_L 324_R 1.475 0.99
15_T 20_E 1.475 0.99
32_Y 46_K 1.474 0.99
339_Q 343_E 1.472 0.99
3_K 71_H 1.457 0.99
255_I 265_C 1.454 0.99
46_K 49_E 1.451 0.99
32_Y 50_I 1.451 0.99
252_Q 257_E 1.423 0.99
115_A 233_E 1.409 0.99
156_T 195_D 1.391 0.99
197_C 200_C 1.391 0.99
281_E 290_K 1.376 0.99
123_L 127_E 1.373 0.99
341_L 344_L 1.357 0.99
264_Y 322_L 1.349 0.99
92_D 99_G 1.339 0.99
275_A 341_L 1.337 0.99
343_E 346_E 1.334 0.99
28_L 32_Y 1.325 0.99
262_N 322_L 1.308 0.98
137_R 211_T 1.306 0.98
340_L 344_L 1.297 0.98
129_V 285_L 1.292 0.98
294_P 303_F 1.272 0.98
25_Y 51_K 1.269 0.98
361_K 369_K 1.262 0.98
125_L 250_V 1.262 0.98
120_N 247_Q 1.247 0.98
216_I 248_V 1.244 0.98
121_M 248_V 1.24 0.98
265_C 321_L 1.24 0.98
262_N 320_D 1.239 0.98
42_E 45_A 1.238 0.98
121_M 216_I 1.235 0.98
141_L 205_R 1.235 0.98
221_D 261_N 1.234 0.98
275_A 329_T 1.228 0.97
140_T 210_K 1.222 0.97
335_E 339_Q 1.221 0.97
158_P 191_T 1.216 0.97
185_H 199_K 1.207 0.97
163_T 170_V 1.202 0.97
144_C 147_C 1.2 0.97
72_A 75_E 1.198 0.97
128_A 250_V 1.196 0.97
9_I 49_E 1.193 0.97
269_I 274_A 1.191 0.97
265_C 283_P 1.19 0.97
225_R 245_Y 1.19 0.97
307_G 320_D 1.18 0.97
335_E 342_Q 1.18 0.97
5_D 14_K 1.166 0.96
69_Y 73_A 1.164 0.96
29_A 47_F 1.163 0.96
125_L 129_V 1.139 0.96
285_L 321_L 1.135 0.95
228_L 246_V 1.131 0.95
144_C 197_C 1.121 0.95
162_P 192_L 1.114 0.95
141_L 207_E 1.113 0.95
306_R 320_D 1.113 0.95
336_R 340_L 1.111 0.95
38_Q 42_E 1.107 0.95
128_A 220_V 1.105 0.95
8_E 13_S 1.103 0.94
198_N 201_H 1.101 0.94
38_Q 41_K 1.1 0.94
123_L 128_A 1.099 0.94
220_V 248_V 1.098 0.94
93_I 99_G 1.093 0.94
336_R 347_S 1.092 0.94
337_Q 344_L 1.091 0.94
27_R 30_M 1.091 0.94
271_F 329_T 1.09 0.94
145_D 206_V 1.087 0.94
272_A 275_A 1.085 0.94
333_L 337_Q 1.085 0.94
28_L 46_K 1.081 0.94
160_T 191_T 1.08 0.94
125_L 128_A 1.076 0.93
339_Q 342_Q 1.075 0.93
146_V 163_T 1.072 0.93
11_G 24_A 1.071 0.93
227_R 245_Y 1.07 0.93
299_T 326_V 1.068 0.93
144_C 200_C 1.068 0.93
93_I 97_V 1.066 0.93
128_A 310_V 1.065 0.93
271_F 341_L 1.056 0.93
143_E 148_H 1.055 0.93
139_P 207_E 1.048 0.92
259_E 262_N 1.046 0.92
130_R 310_V 1.043 0.92
228_L 231_E 1.033 0.92
128_A 221_D 1.029 0.91
255_I 283_P 1.029 0.91
291_L 323_C 1.028 0.91
308_K 318_Q 1.025 0.91
161_C 183_C 1.022 0.91
3_K 8_E 1.017 0.91
139_P 209_S 1.015 0.91
125_L 253_H 1.013 0.90
224_D 313_V 1.007 0.90
96_D 101_I 1.005 0.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3lz8A20.78991000.347Contact Map0.835
4j80A40.751000.375Contact Map0.75
1nltA10.63031000.446Contact Map0.722
2q2gA20.47341000.595Contact Map0.836
3agxA20.47611000.6Contact Map0.834
1c3gA10.44681000.613Contact Map0.782
1bq0A10.27391000.744Contact Map0.367
4j7zA60.28991000.76Contact Map0.772
3i38A120.289999.90.773Contact Map0.886
2ctqA10.2599.90.783Contact Map0.42
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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