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OPENSEQ.org
USG - USG-1 protein
UniProt: P08390 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11059
Length: 337 (330)
Sequences: 3468
Seq/Len: 10.51
USG
Paralog alert: 0.76 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: ARGC DHAS USG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
261_A 307_V 4.007 1.00
142_K 146_D 3.962 1.00
6_N 33_E 3.892 1.00
46_Q 53_T 3.586 1.00
133_L 159_I 3.445 1.00
8_A 67_A 3 1.00
151_S 253_L 2.815 1.00
272_V 291_H 2.784 1.00
272_V 293_S 2.562 1.00
129_V 327_I 2.519 1.00
46_Q 55_T 2.5 1.00
161_A 195_L 2.457 1.00
164_Q 191_F 2.391 1.00
152_R 251_E 2.291 1.00
48_R 53_T 2.222 1.00
318_F 326_K 2.187 1.00
127_I 331_L 2.182 1.00
23_T 325_V 2.169 1.00
207_E 214_R 2.151 1.00
115_P 268_G 2.145 1.00
280_P 295_G 2.139 1.00
80_A 99_L 2.116 1.00
199_M 238_A 2.099 1.00
136_Q 246_Q 2.097 1.00
156_T 247_M 2.093 1.00
81_A 85_E 2.07 1.00
263_D 267_Q 2.053 1.00
27_R 329_E 1.998 1.00
40_N 58_D 1.987 1.00
133_L 157_S 1.958 1.00
147_Q 264_A 1.93 1.00
71_F 328_A 1.924 1.00
136_Q 313_A 1.915 1.00
258_A 297_V 1.914 1.00
92_L 331_L 1.894 1.00
144_L 252_A 1.865 1.00
260_E 263_D 1.825 1.00
140_A 309_F 1.82 1.00
69_L 328_A 1.817 1.00
257_A 260_E 1.815 1.00
20_L 71_F 1.79 1.00
19_A 22_E 1.78 1.00
92_L 127_I 1.766 1.00
141_L 153_I 1.756 1.00
147_Q 260_E 1.713 1.00
19_A 242_Y 1.695 1.00
155_V 248_V 1.689 1.00
117_V 225_Q 1.682 1.00
204_P 211_R 1.678 1.00
273_L 297_V 1.67 1.00
137_L 246_Q 1.66 1.00
116_F 225_Q 1.639 1.00
32_G 328_A 1.638 1.00
263_D 266_V 1.63 1.00
262_R 266_V 1.622 1.00
270_D 290_P 1.59 1.00
59_A 82_W 1.585 1.00
137_L 155_V 1.579 1.00
113_V 142_K 1.577 1.00
137_L 248_V 1.572 1.00
266_V 275_E 1.549 1.00
16_V 321_A 1.544 1.00
140_A 248_V 1.536 1.00
240_V 282_Q 1.502 1.00
154_S 249_N 1.499 1.00
85_E 88_N 1.496 1.00
151_S 251_E 1.495 1.00
7_I 69_L 1.493 1.00
205_D 211_R 1.449 1.00
164_Q 168_A 1.44 1.00
12_A 37_L 1.434 1.00
141_L 250_F 1.428 1.00
157_S 246_Q 1.427 1.00
6_N 35_Y 1.425 1.00
84_E 88_N 1.42 1.00
6_N 68_Q 1.416 1.00
87_T 126_V 1.416 1.00
140_A 265_F 1.414 1.00
170_D 173_A 1.407 0.99
110_V 138_L 1.386 0.99
138_L 219_E 1.379 0.99
10_L 72_F 1.364 0.99
166_K 170_D 1.36 0.99
148_G 256_L 1.353 0.99
137_L 216_I 1.353 0.99
265_F 309_F 1.346 0.99
317_R 322_L 1.346 0.99
13_T 56_V 1.33 0.99
255_P 299_N 1.33 0.99
77_E 99_L 1.321 0.99
265_F 273_L 1.31 0.99
21_L 34_I 1.302 0.99
243_G 315_N 1.3 0.99
10_L 59_A 1.298 0.99
116_F 119_T 1.286 0.99
245_A 282_Q 1.283 0.99
144_L 265_F 1.272 0.99
142_K 223_I 1.267 0.99
64_W 86_A 1.258 0.99
262_R 275_E 1.252 0.99
140_A 311_S 1.246 0.98
292_L 311_S 1.245 0.98
259_E 263_D 1.242 0.98
117_V 120_D 1.242 0.98
31_V 34_I 1.242 0.98
258_A 262_R 1.232 0.98
5_W 332_V 1.23 0.98
83_V 126_V 1.229 0.98
35_Y 57_Q 1.227 0.98
82_W 85_E 1.221 0.98
111_P 330_K 1.218 0.98
164_Q 200_L 1.218 0.98
248_V 309_F 1.21 0.98
250_F 309_F 1.21 0.98
290_P 317_R 1.205 0.98
153_I 250_F 1.202 0.98
248_V 311_S 1.195 0.98
317_R 325_V 1.195 0.98
24_L 32_G 1.184 0.98
202_L 277_N 1.176 0.98
35_Y 67_A 1.169 0.97
136_Q 157_S 1.15 0.97
114_N 117_V 1.147 0.97
292_L 313_A 1.146 0.97
8_A 70_A 1.141 0.97
258_A 299_N 1.141 0.97
250_F 307_V 1.139 0.97
174_G 178_K 1.136 0.97
255_P 305_E 1.134 0.97
79_T 100_F 1.132 0.97
144_L 307_V 1.126 0.97
105_D 124_R 1.124 0.97
92_L 125_N 1.124 0.97
29_F 328_A 1.12 0.96
245_A 310_W 1.114 0.96
72_F 83_V 1.112 0.96
115_P 330_K 1.111 0.96
158_L 238_A 1.109 0.96
70_A 91_C 1.107 0.96
289_T 293_S 1.098 0.96
65_T 89_S 1.098 0.96
232_S 249_N 1.09 0.96
245_A 312_V 1.088 0.96
83_V 93_V 1.087 0.96
147_Q 254_R 1.085 0.96
139_A 268_G 1.065 0.95
84_E 93_V 1.065 0.95
61_E 81_A 1.063 0.95
42_S 45_E 1.062 0.95
262_R 276_E 1.062 0.95
238_A 282_Q 1.06 0.95
119_T 334_E 1.059 0.95
112_E 326_K 1.059 0.95
69_L 332_V 1.058 0.95
25_A 50_G 1.049 0.94
281_T 285_D 1.039 0.94
155_V 216_I 1.038 0.94
7_I 32_G 1.032 0.94
6_N 32_G 1.031 0.94
290_P 322_L 1.03 0.94
136_Q 312_V 1.027 0.94
24_L 325_V 1.021 0.93
22_E 25_A 1.016 0.93
136_Q 311_S 1.013 0.93
156_T 249_N 1.013 0.93
9_V 24_L 1.011 0.93
61_E 85_E 1.003 0.93
199_M 282_Q 1.002 0.92
13_T 39_R 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2yv3A20.95851000.169Contact Map0.671
3tz6A10.96141000.17Contact Map0.747
2r00A20.94361000.175Contact Map0.719
3uw3A20.97331000.188Contact Map0.672
3pzrA20.97331000.19Contact Map0.678
1t4bA20.96741000.197Contact Map0.68
2hjsA10.98521000.197Contact Map0.663
3pwkA20.97921000.216Contact Map0.798
1vknA40.89321000.244Contact Map0.789
2nqtA20.9051000.265Contact Map0.684
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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