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OPENSEQ.org
MCP2 - Methyl-accepting chemotaxis protein II
UniProt: P07017 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10988
Length: 553 (518)
Sequences: 4686
Seq/Len: 9.05
MCP2
Paralog alert: 0.85 [within 20: 0.29] - ratio of genomes with paralogs
Cluster includes: AER MCP1 MCP2 MCP3 MCP4
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
145_N 148_A 4.977 1.00
243_G 248_G 3.952 1.00
229_E 234_N 3.681 1.00
6_R 9_T 3.418 1.00
108_K 124_D 2.506 1.00
223_I 251_A 2.427 1.00
26_G 198_A 2.359 1.00
91_D 95_K 2.232 1.00
255_S 258_Q 2.228 1.00
177_R 181_T 2.176 1.00
170_L 174_K 2.16 1.00
163_E 167_Q 2.157 1.00
403_N 406_S 2.106 1.00
102_T 106_K 2.05 1.00
118_A 122_N 2.017 1.00
139_D 143_Y 2.009 1.00
98_A 102_T 1.974 1.00
219_P 246_E 1.97 1.00
408_S 412_A 1.943 1.00
115_E 118_A 1.93 1.00
136_E 139_D 1.867 1.00
229_E 237_N 1.86 1.00
228_R 249_D 1.858 1.00
135_T 139_D 1.85 1.00
216_L 219_P 1.839 1.00
8_V 12_V 1.835 1.00
223_I 254_V 1.829 1.00
340_K 344_G 1.828 1.00
10_L 215_M 1.827 1.00
214_R 218_T 1.82 1.00
37_Q 187_Y 1.798 1.00
192_W 196_V 1.796 1.00
228_R 256_H 1.756 1.00
174_K 178_D 1.746 1.00
27_S 31_S 1.743 1.00
121_R 125_E 1.739 1.00
371_F 382_V 1.739 1.00
352_I 429_G 1.736 1.00
195_A 199_L 1.735 1.00
126_K 164_A 1.731 1.00
431_V 435_S 1.725 1.00
230_I 257_M 1.679 1.00
140_Y 145_N 1.675 1.00
140_Y 148_A 1.673 1.00
191_Q 195_A 1.67 1.00
323_Q 326_Q 1.659 1.00
181_T 185_D 1.645 1.00
122_N 164_A 1.624 1.00
166_A 170_L 1.624 1.00
105_K 109_S 1.623 1.00
24_I 28_L 1.621 1.00
224_I 253_S 1.62 1.00
40_F 43_S 1.603 1.00
351_E 425_R 1.601 1.00
10_L 245_S 1.585 1.00
470_Q 473_L 1.537 1.00
344_G 435_S 1.512 1.00
117_V 121_R 1.511 1.00
114_P 117_V 1.51 1.00
364_S 368_G 1.51 1.00
7_V 220_L 1.508 1.00
95_K 99_Q 1.502 1.00
136_E 140_Y 1.499 1.00
477_E 480_R 1.498 1.00
19_A 205_L 1.489 1.00
187_Y 191_Q 1.479 1.00
227_I 253_S 1.477 1.00
22_Q 25_S 1.475 1.00
338_G 443_I 1.468 1.00
228_R 232_G 1.468 1.00
124_D 128_K 1.46 1.00
213_R 217_L 1.449 1.00
246_E 249_D 1.448 1.00
448_T 452_D 1.442 0.99
101_A 105_K 1.441 0.99
346_V 437_G 1.44 0.99
8_V 213_R 1.439 0.99
125_E 129_N 1.438 0.99
339_G 444_V 1.428 0.99
316_Q 319_D 1.428 0.99
345_V 433_V 1.426 0.99
333_D 337_H 1.423 0.99
358_K 361_D 1.421 0.99
504_S 508_Q 1.42 0.99
317_N 461_S 1.419 0.99
227_I 250_L 1.414 0.99
427_D 431_V 1.412 0.99
105_K 108_K 1.408 0.99
14_V 18_F 1.405 0.99
337_H 442_N 1.401 0.99
349_M 352_I 1.4 0.99
87_V 91_D 1.393 0.99
249_D 252_Q 1.392 0.99
330_S 333_D 1.388 0.99
490_Q 494_A 1.384 0.99
449_R 452_D 1.384 0.99
335_A 444_V 1.378 0.99
122_N 126_K 1.372 0.99
334_T 442_N 1.372 0.99
196_V 200_V 1.371 0.99
94_R 98_A 1.369 0.99
132_T 136_E 1.365 0.99
33_L 36_S 1.362 0.99
139_D 142_D 1.36 0.99
99_Q 102_T 1.358 0.99
227_I 257_M 1.358 0.99
438_E 442_N 1.343 0.99
358_K 414_E 1.342 0.99
255_S 259_R 1.338 0.99
15_L 18_F 1.336 0.99
119_T 171_S 1.332 0.99
164_A 167_Q 1.322 0.99
438_E 441_N 1.317 0.99
41_V 45_Q 1.313 0.99
462_D 466_R 1.312 0.99
224_I 250_L 1.308 0.99
85_A 88_E 1.306 0.99
199_L 203_L 1.305 0.99
215_M 219_P 1.301 0.99
123_I 161_M 1.296 0.99
487_S 491_E 1.292 0.99
238_T 258_Q 1.292 0.99
238_T 255_S 1.289 0.99
128_K 132_T 1.287 0.99
227_I 254_V 1.286 0.99
92_S 95_K 1.285 0.99
336_Q 448_T 1.285 0.99
402_R 407_R 1.284 0.99
375_I 382_V 1.283 0.99
29_F 194_L 1.282 0.99
440_M 443_I 1.279 0.98
487_S 490_Q 1.279 0.98
254_V 258_Q 1.273 0.98
267_H 505_R 1.271 0.98
238_T 262_T 1.27 0.98
223_I 250_L 1.266 0.98
129_N 132_T 1.25 0.98
44_N 176_Y 1.245 0.98
122_N 125_E 1.245 0.98
205_L 209_W 1.244 0.98
25_S 29_F 1.243 0.98
309_Q 312_A 1.243 0.98
225_A 228_R 1.235 0.98
343_D 347_K 1.231 0.98
469_D 472_A 1.231 0.98
367_D 371_F 1.23 0.98
308_E 312_A 1.229 0.98
31_S 35_H 1.226 0.98
315_K 469_D 1.213 0.98
505_R 508_Q 1.211 0.98
238_T 259_R 1.208 0.98
7_V 216_L 1.204 0.98
257_M 261_L 1.195 0.97
381_A 399_G 1.195 0.97
178_D 182_D 1.193 0.97
247_M 251_A 1.193 0.97
434_E 438_E 1.188 0.97
439_T 443_I 1.188 0.97
336_Q 340_K 1.185 0.97
341_V 432_L 1.184 0.97
113_L 116_M 1.184 0.97
306_S 470_Q 1.184 0.97
225_A 229_E 1.181 0.97
53_L 57_W 1.18 0.97
295_Q 298_S 1.179 0.97
106_K 109_S 1.175 0.97
159_N 163_E 1.175 0.97
173_E 177_R 1.173 0.97
281_E 491_E 1.172 0.97
263_D 267_H 1.169 0.97
219_P 248_G 1.168 0.97
127_Y 161_M 1.161 0.97
487_S 494_A 1.161 0.97
114_P 118_A 1.152 0.97
40_F 183_N 1.15 0.96
239_L 255_S 1.148 0.96
91_D 94_R 1.146 0.96
475_V 478_M 1.145 0.96
259_R 263_D 1.144 0.96
102_T 105_K 1.144 0.96
206_L 210_Y 1.142 0.96
480_R 484_Q 1.141 0.96
381_A 402_R 1.138 0.96
133_A 136_E 1.136 0.96
81_Q 85_A 1.135 0.96
192_W 195_A 1.134 0.96
89_L 92_S 1.132 0.96
230_I 258_Q 1.13 0.96
382_V 479_D 1.129 0.96
189_F 193_Q 1.12 0.96
342_V 436_A 1.118 0.96
15_L 21_L 1.117 0.96
337_H 435_S 1.114 0.96
236_A 515_L 1.112 0.96
260_S 512_A 1.109 0.95
452_D 459_S 1.107 0.95
426_V 429_G 1.105 0.95
322_R 462_D 1.103 0.95
269_R 273_D 1.101 0.95
103_H 106_K 1.101 0.95
125_E 128_K 1.1 0.95
137_L 149_Y 1.099 0.95
243_G 246_E 1.098 0.95
201_V 205_L 1.095 0.95
305_A 309_Q 1.094 0.95
350_H 434_E 1.094 0.95
54_T 57_W 1.093 0.95
41_V 184_A 1.092 0.95
245_S 248_G 1.091 0.95
28_L 32_S 1.091 0.95
93_A 97_L 1.089 0.95
326_Q 329_Q 1.089 0.95
281_E 284_A 1.083 0.95
470_Q 474_A 1.081 0.95
5_I 9_T 1.081 0.95
88_E 91_D 1.08 0.95
209_W 213_R 1.079 0.94
351_E 354_D 1.079 0.94
34_H 191_Q 1.078 0.94
251_A 257_M 1.077 0.94
188_R 192_W 1.077 0.94
84_N 87_V 1.075 0.94
32_S 190_A 1.075 0.94
55_S 59_L 1.074 0.94
219_P 249_D 1.069 0.94
101_A 131_Y 1.068 0.94
371_F 375_I 1.067 0.94
188_R 191_Q 1.062 0.94
99_Q 103_H 1.061 0.94
362_I 418_L 1.06 0.94
498_A 501_E 1.06 0.94
293_T 489_V 1.06 0.94
221_A 246_E 1.057 0.94
234_N 237_N 1.057 0.94
228_R 253_S 1.056 0.94
264_T 268_V 1.051 0.93
107_F 116_M 1.047 0.93
90_L 94_R 1.046 0.93
233_G 250_L 1.043 0.93
252_Q 255_S 1.039 0.93
315_K 319_D 1.036 0.93
236_A 258_Q 1.036 0.93
332_S 447_V 1.035 0.93
224_I 249_D 1.035 0.93
111_A 120_S 1.031 0.93
311_T 472_A 1.029 0.92
116_M 172_S 1.029 0.92
421_D 424_S 1.029 0.92
14_V 21_L 1.027 0.92
302_E 470_Q 1.027 0.92
330_S 449_R 1.026 0.92
345_V 436_A 1.022 0.92
66_N 69_R 1.021 0.92
492_S 495_A 1.02 0.92
241_I 255_S 1.02 0.92
88_E 92_S 1.018 0.92
277_A 281_E 1.016 0.92
12_V 213_R 1.015 0.92
221_A 224_I 1.012 0.92
491_E 494_A 1.011 0.92
219_P 250_L 1.009 0.91
52_E 55_S 1.009 0.91
382_V 412_A 1.009 0.91
230_I 254_V 1.008 0.91
196_V 203_L 1.008 0.91
183_N 187_Y 1.008 0.91
129_N 160_A 1.007 0.91
276_Y 280_R 1.007 0.91
29_F 201_V 1.007 0.91
84_N 88_E 1.007 0.91
375_I 440_M 1.005 0.91
152_Q 155_Q 1.005 0.91
64_R 68_S 1.004 0.91
423_V 426_V 1.004 0.91
30_F 191_Q 1.003 0.91
19_A 22_Q 1.003 0.91
501_E 505_R 1.001 0.91
121_R 124_D 1.001 0.91
54_T 58_D 1.001 0.91
285_G 488_L 1 0.91
182_D 186_D 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3zx6A20.6131000.409Contact Map0.57
1qu7A20.41051000.552Contact Map0.527
2ch7A10.48281000.605Contact Map0.337
3g67A20.38521000.656Contact Map0.638
4i3mA10.30561000.77Contact Map0.465
4gn0A40.188199.40.876Contact Map0.667
2f95B10.291199.30.886Contact Map0.361
2d4uA20.312899.10.896Contact Map0.585
3zccA20.197199.10.896Contact Map0.616
4gycB10.2441990.899Contact Map0.427
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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