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OPENSEQ.org
NLPA - Lipoprotein 28
UniProt: P04846 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10657
Length: 272 (258)
Sequences: 1589
Seq/Len: 6.16
NLPA
Paralog alert: 0.59 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: METQ NLPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
157_T 173_D 4.256 1.00
132_A 198_D 3.212 1.00
35_K 65_V 3.197 1.00
122_I 129_K 3.157 1.00
103_K 236_E 3.064 1.00
254_P 258_K 3.024 1.00
90_R 94_E 2.957 1.00
37_G 82_L 2.951 1.00
133_T 181_M 2.94 1.00
258_K 262_T 2.827 1.00
53_V 255_E 2.729 1.00
135_A 197_V 2.712 1.00
235_R 238_N 2.685 1.00
130_E 177_H 2.543 1.00
134_V 199_V 2.424 1.00
133_T 179_Q 2.408 1.00
97_N 102_Y 2.404 1.00
108_G 248_L 2.37 1.00
55_K 61_D 2.334 1.00
129_K 132_A 2.251 1.00
120_K 193_D 2.233 1.00
238_N 241_A 2.229 1.00
107_V 244_V 2.22 1.00
95_Q 99_A 2.213 1.00
123_K 127_Q 2.212 1.00
96_D 102_Y 2.198 1.00
35_K 63_E 2.103 1.00
148_L 151_Q 2.047 1.00
137_P 146_A 2.033 1.00
168_A 182_E 2.025 1.00
104_L 233_V 1.997 1.00
49_V 256_V 1.992 1.00
33_H 61_D 1.92 1.00
33_H 63_E 1.894 1.00
136_I 143_L 1.866 1.00
78_N 103_K 1.817 1.00
258_K 261_E 1.784 1.00
80_G 235_R 1.778 1.00
171_I 180_I 1.77 1.00
245_K 249_Q 1.762 1.00
134_V 178_L 1.732 1.00
57_K 246_E 1.721 1.00
57_K 249_Q 1.674 1.00
117_G 199_V 1.628 1.00
105_V 236_E 1.588 0.99
84_A 234_A 1.546 0.99
116_A 218_S 1.545 0.99
128_I 132_A 1.534 0.99
152_K 223_D 1.523 0.99
232_L 248_L 1.504 0.99
84_A 247_F 1.503 0.99
34_I 243_N 1.499 0.99
60_L 243_N 1.467 0.99
37_G 77_T 1.464 0.99
109_N 229_V 1.459 0.99
48_E 51_K 1.456 0.99
153_E 220_F 1.446 0.99
128_I 199_V 1.443 0.99
212_L 217_D 1.409 0.98
71_L 92_F 1.406 0.98
136_I 180_I 1.404 0.98
75_D 96_D 1.392 0.98
213_S 216_H 1.385 0.98
54_A 60_L 1.383 0.98
53_V 250_S 1.369 0.98
248_L 252_Q 1.362 0.98
139_D 142_N 1.356 0.98
90_R 106_A 1.347 0.98
122_I 198_D 1.345 0.98
21_L 24_C 1.337 0.98
241_A 244_V 1.32 0.97
60_L 246_E 1.319 0.97
122_I 132_A 1.3 0.97
254_P 257_A 1.299 0.97
259_A 263_I 1.293 0.97
155_L 178_L 1.293 0.97
240_N 245_K 1.272 0.96
151_Q 157_T 1.269 0.96
242_E 246_E 1.265 0.96
53_V 56_E 1.254 0.96
197_V 200_A 1.251 0.96
157_T 172_T 1.251 0.96
34_I 60_L 1.24 0.96
75_D 79_H 1.239 0.96
183_L 191_V 1.21 0.95
124_T 127_Q 1.21 0.95
38_V 47_A 1.206 0.95
125_V 128_I 1.186 0.94
159_K 172_T 1.175 0.94
236_E 239_K 1.168 0.94
110_T 248_L 1.162 0.93
86_V 110_T 1.159 0.93
130_E 176_R 1.155 0.93
213_S 217_D 1.15 0.93
53_V 256_V 1.149 0.93
49_V 53_V 1.147 0.93
116_A 221_I 1.144 0.93
77_T 82_L 1.144 0.93
128_I 134_V 1.143 0.93
234_A 238_N 1.138 0.92
97_N 103_K 1.138 0.92
158_L 172_T 1.137 0.92
45_D 263_I 1.121 0.92
75_D 100_H 1.119 0.92
159_K 170_D 1.112 0.91
43_E 111_F 1.111 0.91
90_R 231_I 1.11 0.91
49_V 52_K 1.104 0.91
105_V 239_K 1.103 0.91
203_S 230_N 1.101 0.91
108_G 232_L 1.089 0.90
135_A 191_V 1.084 0.90
97_N 104_L 1.081 0.90
86_V 111_F 1.075 0.89
38_V 44_Q 1.068 0.89
45_D 264_F 1.059 0.88
70_S 73_P 1.054 0.88
160_E 163_G 1.053 0.88
43_E 113_F 1.05 0.88
90_R 109_N 1.05 0.88
54_A 250_S 1.047 0.87
84_A 244_V 1.047 0.87
45_D 48_E 1.036 0.87
51_K 55_K 1.03 0.86
162_K 166_P 1.03 0.86
199_V 219_V 1.022 0.86
234_A 237_D 1.018 0.85
24_C 27_S 1.016 0.85
34_I 247_F 1.004 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ir1A60.86761000.469Contact Map0.839
3up9A10.8861000.489Contact Map0.698
4gotA10.90071000.496Contact Map0.854
4ib2A20.90071000.497Contact Map0.867
1xs5A10.88241000.509Contact Map0.88
4k3fA10.88241000.513Contact Map0.85
3tqwA20.88241000.514Contact Map0.84
3gxaA60.94851000.516Contact Map0.838
3k2dA20.87131000.53Contact Map0.837
4ef1A20.89341000.547Contact Map0.787
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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