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TYRB - Aromatic-amino-acid aminotransferase
UniProt: P04693 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11040
Length: 397 (385)
Sequences: 18587
Seq/Len: 48.28
TYRB
Paralog alert: 0.94 [within 20: 0.24] - ratio of genomes with paralogs
Cluster includes: AAT ALAA ALAC ARNB AVTA CSDA HIS8 ISCS MALY RFFA SERC SUFS TYRB YBDL YDCR YJIR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
54_A 58_A 3.24 1.00
321_A 383_T 3.226 1.00
164_L 204_A 3.185 1.00
366_F 395_A 3.087 1.00
320_L 324_Q 2.951 1.00
325_E 387_Q 2.94 1.00
192_N 196_D 2.913 1.00
123_G 144_E 2.873 1.00
101_T 107_A 2.783 1.00
84_F 90_V 2.745 1.00
361_R 365_E 2.517 1.00
388_R 392_A 2.493 1.00
78_A 300_N 2.452 1.00
122_S 174_S 2.444 1.00
340_D 353_G 2.438 1.00
388_R 391_K 2.341 1.00
329_V 390_A 2.316 1.00
118_Y 143_F 2.296 1.00
74_C 296_A 2.277 1.00
47_Q 51_E 2.224 1.00
51_E 55_R 2.168 1.00
256_V 295_V 2.156 1.00
191_T 194_Q 2.133 1.00
196_D 200_E 2.123 1.00
77_H 81_P 2.1 1.00
382_N 385_N 2.079 1.00
31_L 389_V 2.036 1.00
328_K 332_T 2.003 1.00
109_K 113_D 1.971 1.00
77_H 93_Q 1.947 1.00
202_L 209_P 1.939 1.00
161_N 197_A 1.905 1.00
325_E 383_T 1.895 1.00
327_V 331_S 1.881 1.00
329_V 332_T 1.878 1.00
324_Q 328_K 1.876 1.00
175_I 210_F 1.856 1.00
327_V 343_L 1.852 1.00
123_G 146_S 1.849 1.00
73_N 77_H 1.847 1.00
138_F 143_F 1.844 1.00
157_G 194_Q 1.843 1.00
164_L 197_A 1.831 1.00
210_F 242_S 1.828 1.00
193_D 196_D 1.824 1.00
214_A 244_S 1.815 1.00
329_V 391_K 1.797 1.00
197_A 200_E 1.791 1.00
81_P 300_N 1.754 1.00
80_A 93_Q 1.737 1.00
128_D 147_T 1.734 1.00
104_G 242_S 1.73 1.00
78_A 81_P 1.73 1.00
206_E 238_P 1.728 1.00
159_R 162_D 1.708 1.00
55_R 297_A 1.7 1.00
329_V 394_A 1.689 1.00
162_D 166_T 1.687 1.00
111_G 240_L 1.679 1.00
111_G 210_F 1.673 1.00
331_S 341_Y 1.657 1.00
151_Y 194_Q 1.625 1.00
124_V 138_F 1.62 1.00
325_E 329_V 1.618 1.00
50_A 54_A 1.608 1.00
123_G 168_K 1.594 1.00
313_E 317_T 1.586 1.00
162_D 165_A 1.572 1.00
74_C 300_N 1.559 1.00
79_I 258_G 1.553 1.00
200_E 204_A 1.539 1.00
51_E 54_A 1.531 1.00
94_Q 266_A 1.528 1.00
391_K 395_A 1.524 1.00
164_L 205_R 1.51 1.00
167_L 201_I 1.508 1.00
332_T 394_A 1.508 1.00
202_L 207_L 1.507 1.00
135_V 139_A 1.503 1.00
160_F 201_I 1.501 1.00
329_V 387_Q 1.491 1.00
288_P 291_G 1.48 1.00
383_T 387_Q 1.471 1.00
72_L 293_Q 1.469 1.00
112_A 138_F 1.467 1.00
200_E 203_K 1.451 1.00
192_N 227_Y 1.442 1.00
326_L 350_S 1.44 1.00
329_V 333_E 1.438 1.00
80_A 96_V 1.433 1.00
52_A 297_A 1.428 1.00
326_L 390_A 1.423 1.00
81_P 85_G 1.419 1.00
313_E 316_R 1.419 1.00
123_G 173_R 1.417 1.00
112_A 177_L 1.411 1.00
79_I 100_Q 1.411 1.00
361_R 396_V 1.404 0.99
78_A 296_A 1.403 0.99
360_D 364_E 1.393 0.99
26_S 367_G 1.387 0.99
302_E 310_A 1.383 0.99
128_D 149_P 1.374 0.99
366_F 392_A 1.373 0.99
123_G 172_A 1.371 0.99
55_R 59_Q 1.369 0.99
149_P 162_D 1.361 0.99
318_R 383_T 1.343 0.99
327_V 350_S 1.341 0.99
112_A 118_Y 1.337 0.99
160_F 197_A 1.327 0.99
362_L 393_F 1.325 0.99
70_E 277_K 1.323 0.99
261_V 273_L 1.314 0.99
387_Q 391_K 1.305 0.99
327_V 341_Y 1.303 0.99
331_S 343_L 1.299 0.99
201_I 205_R 1.299 0.99
333_E 394_A 1.298 0.99
317_T 320_L 1.296 0.99
76_R 80_A 1.294 0.99
245_F 295_V 1.292 0.99
79_I 96_V 1.284 0.99
178_L 198_V 1.281 0.99
370_L 374_G 1.277 0.99
318_R 321_A 1.267 0.99
194_Q 197_A 1.263 0.99
53_E 294_V 1.251 0.99
124_V 175_I 1.246 0.98
115_L 208_I 1.237 0.98
176_V 207_L 1.231 0.98
201_I 207_L 1.23 0.98
50_A 58_A 1.228 0.98
165_A 169_T 1.225 0.98
70_E 76_R 1.223 0.98
164_L 201_I 1.22 0.98
106_G 280_V 1.22 0.98
192_N 232_I 1.22 0.98
334_M 338_N 1.219 0.98
164_L 168_K 1.21 0.98
193_D 197_A 1.208 0.98
359_V 370_L 1.206 0.98
83_L 260_S 1.202 0.98
259_L 276_L 1.195 0.98
126_V 145_V 1.195 0.98
73_N 93_Q 1.191 0.98
91_L 260_S 1.19 0.98
326_L 386_V 1.184 0.98
118_Y 124_V 1.18 0.98
280_V 284_Y 1.175 0.98
296_A 300_N 1.175 0.98
83_L 258_G 1.175 0.98
275_Q 278_A 1.174 0.98
47_Q 50_A 1.173 0.98
95_R 266_A 1.171 0.98
243_N 258_G 1.17 0.97
113_D 141_A 1.165 0.97
74_C 293_Q 1.162 0.97
297_A 300_N 1.16 0.97
92_K 266_A 1.16 0.97
192_N 231_A 1.156 0.97
328_K 331_S 1.152 0.97
161_N 165_A 1.149 0.97
263_C 273_L 1.142 0.97
199_I 209_P 1.134 0.97
323_R 327_V 1.133 0.97
31_L 386_V 1.127 0.97
75_Y 100_Q 1.126 0.97
135_V 147_T 1.126 0.97
317_T 321_A 1.126 0.97
196_D 235_A 1.12 0.96
51_E 58_A 1.118 0.96
97_A 273_L 1.114 0.96
357_A 360_D 1.113 0.96
376_M 389_V 1.112 0.96
167_L 207_L 1.11 0.96
274_G 278_A 1.11 0.96
102_L 106_G 1.108 0.96
50_A 57_N 1.107 0.96
168_K 171_P 1.106 0.96
209_P 229_I 1.104 0.96
151_Y 159_R 1.103 0.96
52_A 56_L 1.091 0.96
120_P 142_G 1.091 0.96
53_E 57_N 1.086 0.96
324_Q 343_L 1.085 0.96
92_K 95_R 1.083 0.96
115_L 175_I 1.078 0.95
196_D 232_I 1.077 0.95
104_G 244_S 1.073 0.95
326_L 329_V 1.072 0.95
138_F 145_V 1.07 0.95
208_I 240_L 1.068 0.95
240_L 261_V 1.066 0.95
203_K 236_G 1.063 0.95
297_A 301_D 1.048 0.94
362_L 370_L 1.041 0.94
125_W 173_R 1.041 0.94
125_W 148_Y 1.038 0.94
264_E 267_E 1.031 0.94
240_L 259_L 1.021 0.93
74_C 77_H 1.02 0.93
85_G 306_A 1.018 0.93
221_G 345_Q 1.015 0.93
318_R 322_M 1.011 0.93
114_F 279_T 1.011 0.93
168_K 173_R 1.011 0.93
323_R 378_V 1.011 0.93
119_F 122_S 1.01 0.93
199_I 239_A 1.01 0.93
102_L 288_P 1.008 0.93
161_N 164_L 1.006 0.93
323_R 344_N 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f4eA20.98491000.26Contact Map0.531
7aatA20.9951000.26Contact Map0.576
4h51A20.96981000.265Contact Map0.579
4eu1A20.96731000.268Contact Map0.523
1ajsA10.98741000.274Contact Map0.565
1yaaA40.98741000.275Contact Map0.592
2q7wA10.98491000.28Contact Map0.549
3fslA60.98991000.288Contact Map0.592
2ay1A20.97731000.292Contact Map0.574
3k7yA10.98241000.295Contact Map0.514
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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