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OPENSEQ.org
GLCA - Glycolate permease GlcA
UniProt: Q46839 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12995
Length: 560 (549)
Sequences: 760
Seq/Len: 1.38
GLCA
Paralog alert: 0.34 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: GLCA LLDP
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
524_R 527_E 3.115 1.00
450_F 454_S 3.008 1.00
237_T 257_V 2.429 1.00
549_L 553_V 2.399 1.00
411_I 414_K 2.384 0.99
180_A 476_G 2.383 0.99
27_F 49_L 2.321 0.99
264_L 268_V 2.269 0.99
52_L 56_F 2.204 0.99
496_A 547_T 2.203 0.99
545_I 549_L 2.193 0.99
456_F 540_A 2.168 0.99
540_A 544_G 2.161 0.99
55_I 65_A 2.09 0.98
30_V 35_L 2.077 0.98
124_S 258_S 2.026 0.98
51_I 429_V 1.993 0.98
229_V 265_F 1.931 0.97
177_I 195_A 1.88 0.96
51_I 65_A 1.864 0.96
407_A 411_I 1.843 0.96
392_I 402_G 1.843 0.96
73_F 421_G 1.824 0.95
389_I 393_F 1.803 0.95
391_S 395_L 1.797 0.95
10_P 17_S 1.779 0.94
96_A 408_E 1.776 0.94
97_S 397_V 1.776 0.94
111_T 116_L 1.731 0.93
541_S 545_I 1.699 0.92
403_I 407_A 1.691 0.92
27_F 31_A 1.688 0.92
180_A 494_V 1.678 0.92
456_F 544_G 1.678 0.92
11_M 57_A 1.67 0.92
308_I 312_S 1.658 0.91
30_V 34_V 1.649 0.91
241_T 253_T 1.644 0.91
398_G 401_K 1.644 0.91
320_L 386_I 1.642 0.91
386_I 390_I 1.612 0.90
346_F 374_F 1.605 0.89
92_K 412_S 1.596 0.89
37_L 41_V 1.595 0.89
476_G 494_V 1.592 0.89
387_A 391_S 1.533 0.86
459_W 536_S 1.521 0.86
240_F 244_Y 1.51 0.85
19_L 221_K 1.5 0.84
399_I 403_I 1.497 0.84
48_I 389_I 1.488 0.84
195_A 499_S 1.475 0.83
206_V 539_F 1.473 0.83
329_F 333_F 1.473 0.83
480_S 494_V 1.473 0.83
488_V 493_L 1.471 0.83
222_E 273_N 1.471 0.83
165_T 506_M 1.47 0.83
53_I 57_A 1.463 0.82
62_I 66_F 1.463 0.82
205_L 538_I 1.455 0.82
4_W 8_Y 1.447 0.81
225_P 269_W 1.445 0.81
469_T 504_G 1.431 0.80
47_L 69_A 1.426 0.80
199_L 238_Q 1.424 0.80
42_A 128_L 1.423 0.80
97_S 395_L 1.422 0.80
122_G 163_A 1.42 0.80
101_D 104_R 1.404 0.79
400_K 404_G 1.398 0.78
329_F 332_L 1.396 0.78
227_A 232_G 1.389 0.78
180_A 191_I 1.389 0.78
157_A 478_L 1.381 0.77
117_Q 151_F 1.376 0.77
204_V 235_A 1.376 0.77
537_L 541_S 1.37 0.76
197_R 243_N 1.367 0.76
56_F 62_I 1.364 0.76
158_G 531_Y 1.362 0.76
429_V 464_L 1.361 0.76
20_V 57_A 1.36 0.76
129_L 137_A 1.358 0.75
215_D 219_G 1.355 0.75
312_S 394_I 1.348 0.75
236_V 240_F 1.347 0.75
463_F 532_T 1.345 0.74
260_V 264_L 1.338 0.74
118_V 159_L 1.332 0.73
122_G 195_A 1.329 0.73
315_L 367_P 1.32 0.72
167_P 468_D 1.316 0.72
168_V 468_D 1.311 0.72
26_I 228_L 1.309 0.72
400_K 403_I 1.302 0.71
211_V 223_T 1.294 0.70
329_F 487_N 1.293 0.70
181_G 186_I 1.286 0.70
122_G 210_L 1.271 0.68
96_A 404_G 1.269 0.68
106_S 311_W 1.261 0.67
49_L 53_I 1.259 0.67
114_Q 277_A 1.253 0.67
253_T 257_V 1.252 0.67
233_S 257_V 1.25 0.66
427_A 509_P 1.246 0.66
147_V 519_T 1.245 0.66
122_G 126_G 1.245 0.66
116_L 226_A 1.243 0.66
127_A 462_V 1.24 0.66
468_D 501_G 1.239 0.65
389_I 429_V 1.237 0.65
18_A 442_V 1.237 0.65
137_A 526_S 1.234 0.65
10_P 21_A 1.234 0.65
20_V 23_I 1.233 0.65
420_I 511_S 1.229 0.64
226_A 265_F 1.227 0.64
96_A 401_K 1.225 0.64
430_T 436_S 1.223 0.64
333_F 339_F 1.22 0.64
233_S 258_S 1.22 0.64
506_M 521_M 1.219 0.64
162_I 213_M 1.217 0.63
505_K 511_S 1.216 0.63
110_I 265_F 1.211 0.63
508_S 513_A 1.208 0.63
198_Q 550_Q 1.205 0.62
165_T 468_D 1.205 0.62
48_I 52_L 1.198 0.62
499_S 550_Q 1.197 0.61
90_L 388_A 1.191 0.61
396_G 401_K 1.185 0.60
204_V 231_G 1.176 0.59
512_I 529_F 1.174 0.59
29_F 529_F 1.172 0.59
233_S 237_T 1.171 0.59
23_I 51_I 1.169 0.59
84_I 453_F 1.167 0.59
19_L 390_I 1.162 0.58
157_A 515_A 1.16 0.58
303_S 306_Q 1.154 0.57
514_V 535_H 1.154 0.57
27_F 46_T 1.154 0.57
104_R 145_L 1.152 0.57
52_L 303_S 1.149 0.57
509_P 513_A 1.147 0.57
83_I 90_L 1.144 0.56
205_L 208_F 1.141 0.56
26_I 344_I 1.14 0.56
431_N 470_S 1.14 0.56
483_A 488_V 1.138 0.56
476_G 480_S 1.137 0.56
302_Y 306_Q 1.135 0.55
126_G 163_A 1.133 0.55
468_D 499_S 1.132 0.55
305_G 309_R 1.129 0.55
216_G 219_G 1.127 0.55
169_A 195_A 1.126 0.54
265_F 269_W 1.126 0.54
449_M 452_F 1.126 0.54
166_A 251_D 1.125 0.54
238_Q 502_V 1.121 0.54
75_Y 428_F 1.121 0.54
48_I 51_I 1.12 0.54
206_V 558_L 1.118 0.54
237_T 254_S 1.116 0.53
456_F 537_L 1.115 0.53
419_S 440_A 1.112 0.53
82_W 177_I 1.11 0.53
446_T 449_M 1.11 0.53
61_P 224_W 1.107 0.53
93_L 129_L 1.105 0.52
117_Q 149_L 1.104 0.52
184_T 255_A 1.102 0.52
301_E 545_I 1.101 0.52
47_L 429_V 1.1 0.52
29_F 429_V 1.099 0.52
208_F 227_A 1.099 0.52
46_T 84_I 1.099 0.52
483_A 506_M 1.098 0.52
169_A 468_D 1.098 0.52
191_I 494_V 1.098 0.52
238_Q 468_D 1.093 0.51
277_A 282_Q 1.091 0.51
503_T 539_F 1.091 0.51
188_P 192_G 1.089 0.51
103_I 311_W 1.089 0.51
28_F 145_L 1.088 0.51
550_Q 557_M 1.087 0.51
358_A 365_P 1.086 0.50
225_P 229_V 1.084 0.50
193_A 243_N 1.083 0.50
126_G 165_T 1.081 0.50
49_L 369_D 1.081 0.50
215_D 220_V 1.08 0.50
47_L 133_A 1.079 0.50
58_F 311_W 1.074 0.49
93_L 446_T 1.07 0.49
197_R 200_P 1.068 0.49
36_R 527_E 1.068 0.49
69_A 429_V 1.067 0.49
205_L 374_F 1.065 0.48
49_L 154_L 1.065 0.48
309_R 312_S 1.065 0.48
227_A 231_G 1.064 0.48
201_F 240_F 1.063 0.48
169_A 238_Q 1.063 0.48
255_A 449_M 1.062 0.48
128_L 318_T 1.061 0.48
95_V 101_D 1.06 0.48
44_A 418_L 1.059 0.48
83_I 172_A 1.059 0.48
25_I 131_G 1.058 0.48
505_K 510_Q 1.057 0.48
502_V 510_Q 1.055 0.47
128_L 384_I 1.055 0.47
497_N 505_K 1.054 0.47
53_I 541_S 1.05 0.47
44_A 422_M 1.049 0.47
56_F 389_I 1.045 0.46
172_A 177_I 1.044 0.46
223_T 421_G 1.043 0.46
128_L 132_A 1.04 0.46
48_I 404_G 1.04 0.46
217_W 221_K 1.038 0.46
185_G 219_G 1.036 0.45
244_Y 488_V 1.034 0.45
128_L 160_C 1.033 0.45
179_V 439_L 1.033 0.45
136_G 171_G 1.033 0.45
36_R 95_V 1.032 0.45
128_L 247_P 1.032 0.45
505_K 514_V 1.031 0.45
70_G 393_F 1.026 0.44
40_H 415_W 1.025 0.44
119_L 262_L 1.024 0.44
122_G 231_G 1.024 0.44
55_I 319_V 1.023 0.44
457_L 478_L 1.022 0.44
239_F 244_Y 1.021 0.44
30_V 445_G 1.02 0.44
177_I 472_N 1.02 0.44
52_L 178_L 1.019 0.44
197_R 239_F 1.018 0.44
170_F 250_P 1.017 0.44
231_G 235_A 1.012 0.43
56_F 260_V 1.011 0.43
225_P 271_P 1.011 0.43
83_I 135_F 1.01 0.43
120_L 263_A 1.007 0.43
209_W 453_F 1.007 0.43
45_I 477_S 1.007 0.43
174_G 246_G 1.006 0.42
23_I 49_L 1.006 0.42
332_L 335_P 1.006 0.42
230_A 262_L 1.005 0.42
71_Y 428_F 1.005 0.42
48_I 190_H 1.005 0.42
324_W 383_A 1.005 0.42
366_T 369_D 1.005 0.42
81_A 417_I 1.003 0.42
124_S 230_A 1.003 0.42
450_F 508_S 1.002 0.42
110_I 120_L 1.001 0.42
194_M 491_T 1.001 0.42
131_G 500_G 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4f35D40.733999.40.906Contact Map0.334
1v76A20.140.986Contact Map0.081
3aqpA20.30183.80.986Contact Map0.215
2loqA10.17143.50.986Contact Map0.054
4jc9S140.08573.50.986Contact Map0.735
1p22C10.03932.30.988Contact Map
1nkzB30.07142.30.988Contact Map0.743
2l6wA20.053620.988Contact Map0.251
1p68A10.062520.988Contact Map0.062
4ixqK20.07861.70.988Contact Map0.274
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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