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OPENSEQ.org
PPPA - Leader peptidase PppA
UniProt: Q46836 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12992
Length: 269 (262)
Sequences: 1163
Seq/Len: 4.44
PPPA
Paralog alert: 0.09 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: LEP4 PPPA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
77_D 92_R 4.964 1.00
101_R 145_D 4.245 1.00
63_R 72_T 3.399 1.00
135_W 153_F 2.808 1.00
215_L 227_V 2.717 1.00
157_V 214_A 2.71 1.00
24_I 28_L 2.485 1.00
32_I 141_V 2.468 1.00
139_A 149_L 2.436 1.00
206_M 209_V 2.408 1.00
71_Q 77_D 2.34 1.00
113_F 134_A 2.328 1.00
22_L 81_L 2.213 1.00
236_L 239_A 2.211 1.00
18_T 110_A 2.196 1.00
77_D 93_D 2.185 1.00
59_L 62_P 2.15 1.00
133_S 260_I 1.993 1.00
149_L 154_T 1.953 1.00
109_T 137_I 1.864 1.00
57_I 65_H 1.838 1.00
151_D 210_L 1.782 1.00
58_S 62_P 1.746 0.99
84_W 100_K 1.727 0.99
73_I 78_N 1.685 0.99
73_I 93_D 1.673 0.99
77_D 87_L 1.664 0.99
149_L 252_G 1.661 0.99
140_S 256_S 1.655 0.99
109_T 113_F 1.651 0.99
179_T 183_V 1.611 0.99
116_A 133_S 1.6 0.99
195_A 199_L 1.598 0.99
108_L 141_V 1.589 0.99
100_K 104_L 1.584 0.99
71_Q 93_D 1.567 0.99
82_F 86_M 1.545 0.98
161_G 218_W 1.54 0.98
116_A 126_G 1.538 0.98
31_V 35_Y 1.537 0.98
74_R 77_D 1.511 0.98
128_A 164_A 1.499 0.98
181_V 217_G 1.495 0.98
78_N 87_L 1.494 0.98
126_G 130_M 1.488 0.98
215_L 259_G 1.475 0.98
88_K 95_Q 1.448 0.97
195_A 203_A 1.438 0.97
71_Q 74_R 1.438 0.97
79_I 83_S 1.415 0.97
101_R 141_V 1.409 0.97
113_F 130_M 1.401 0.97
33_W 57_I 1.4 0.97
68_H 96_A 1.39 0.96
21_G 110_A 1.387 0.96
192_R 202_E 1.376 0.96
76_R 92_R 1.371 0.96
29_N 105_V 1.37 0.96
174_L 178_V 1.363 0.96
149_L 211_L 1.347 0.96
44_A 47_H 1.346 0.96
69_C 94_C 1.335 0.95
258_G 262_T 1.328 0.95
67_P 98_I 1.32 0.95
22_L 110_A 1.312 0.95
29_N 32_I 1.312 0.95
227_V 258_G 1.303 0.94
112_A 133_S 1.299 0.94
43_M 46_F 1.293 0.94
28_L 138_A 1.29 0.94
136_L 256_S 1.28 0.94
37_I 57_I 1.265 0.93
184_G 224_L 1.255 0.93
141_V 145_D 1.251 0.93
211_L 252_G 1.229 0.92
26_S 34_R 1.221 0.91
231_A 255_L 1.215 0.91
21_G 25_G 1.206 0.91
26_S 64_S 1.205 0.91
192_R 206_M 1.194 0.90
188_F 228_A 1.192 0.90
77_D 83_S 1.188 0.90
180_G 216_G 1.185 0.90
151_D 155_Q 1.178 0.89
99_S 103_P 1.162 0.89
180_G 184_G 1.159 0.88
150_P 210_L 1.155 0.88
32_I 142_I 1.153 0.88
139_A 154_T 1.152 0.88
43_M 47_H 1.147 0.88
193_W 196_G 1.136 0.87
32_I 105_V 1.129 0.87
105_V 141_V 1.129 0.87
17_A 117_S 1.127 0.86
199_L 203_A 1.126 0.86
74_R 92_R 1.124 0.86
30_V 36_P 1.122 0.86
73_I 76_R 1.108 0.85
188_F 212_F 1.106 0.85
226_N 262_T 1.099 0.85
66_C 94_C 1.097 0.84
14_P 114_L 1.094 0.84
166_W 179_T 1.092 0.84
66_C 69_C 1.082 0.83
18_T 114_L 1.058 0.81
147_Q 250_P 1.056 0.81
27_F 34_R 1.05 0.81
81_L 107_L 1.049 0.81
22_L 103_P 1.038 0.80
212_F 227_V 1.038 0.80
137_I 141_V 1.03 0.79
44_A 49_E 1.015 0.77
63_R 74_R 1.011 0.77
112_A 137_I 1.005 0.77
223_S 262_T 1.003 0.76
185_F 209_V 1.002 0.76
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3s0xA20.531699.20.813Contact Map0.474
3py7A10.364346.10.949Contact Map0.49
2xzfA10.234230.70.954Contact Map0.359
2ct0A10.267726.70.955Contact Map0.208
3j20Y10.185925.20.956Contact Map0.181
3u6pA10.234224.40.956Contact Map0.366
1ee8A20.260222.10.957Contact Map0.373
1iymA10.204522.10.957Contact Map0.356
1k82A40.234221.60.957Contact Map0.438
2ep4A10.230520.10.958Contact Map0.019
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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