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YGHD - Putative type II secretion system M-type protein YghD
UniProt: Q46832 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12988
Length: 178 (153)
Sequences: 212
Seq/Len: 1.39
YGHD
Paralog alert: 0.05 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: GSPM YGHD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
51_G 55_L 2.12 0.99
36_E 39_M 1.964 0.97
32_R 40_L 1.922 0.97
39_M 43_A 1.594 0.89
172_R 175_F 1.552 0.87
31_G 90_A 1.54 0.87
139_L 168_V 1.46 0.82
65_E 92_R 1.447 0.82
132_E 169_N 1.437 0.81
115_V 131_I 1.417 0.80
115_V 127_I 1.406 0.79
51_G 134_V 1.394 0.78
39_M 121_A 1.393 0.78
48_F 52_Y 1.371 0.77
83_N 154_V 1.368 0.76
66_Q 143_L 1.352 0.75
46_F 49_S 1.351 0.75
112_A 164_K 1.345 0.75
89_I 134_V 1.34 0.74
49_S 131_I 1.315 0.72
29_L 75_V 1.31 0.72
37_K 122_D 1.27 0.68
79_T 154_V 1.267 0.68
28_H 37_K 1.261 0.68
131_I 148_E 1.259 0.67
159_V 168_V 1.257 0.67
110_A 146_L 1.254 0.67
28_H 139_L 1.252 0.67
57_W 100_A 1.228 0.65
60_L 114_S 1.228 0.65
70_I 135_V 1.22 0.64
42_A 56_I 1.218 0.64
37_K 75_V 1.215 0.63
108_D 165_P 1.21 0.63
102_V 128_Q 1.21 0.63
104_R 158_D 1.207 0.63
134_V 139_L 1.205 0.62
37_K 107_S 1.199 0.62
81_L 168_V 1.176 0.60
121_A 166_G 1.173 0.59
49_S 141_K 1.162 0.58
147_D 152_L 1.162 0.58
105_V 135_V 1.16 0.58
100_A 171_Q 1.157 0.58
78_N 91_A 1.154 0.58
88_I 103_S 1.148 0.57
143_L 165_P 1.148 0.57
30_A 113_H 1.146 0.57
47_L 154_V 1.142 0.56
134_V 167_M 1.139 0.56
53_Y 57_W 1.138 0.56
49_S 129_V 1.137 0.56
100_A 161_A 1.136 0.56
49_S 53_Y 1.129 0.55
39_M 127_I 1.129 0.55
62_E 159_V 1.125 0.55
136_F 159_V 1.103 0.52
40_L 114_S 1.099 0.52
51_G 92_R 1.094 0.51
80_R 122_D 1.093 0.51
129_V 136_F 1.092 0.51
52_Y 57_W 1.087 0.51
33_S 40_L 1.085 0.51
42_A 114_S 1.069 0.49
45_V 52_Y 1.069 0.49
129_V 149_K 1.068 0.49
90_A 134_V 1.066 0.49
43_A 162_A 1.053 0.47
123_R 171_Q 1.05 0.47
91_A 128_Q 1.038 0.46
96_T 130_W 1.035 0.46
46_F 148_E 1.034 0.45
75_V 169_N 1.033 0.45
70_I 75_V 1.032 0.45
50_V 54_V 1.025 0.45
51_G 176_G 1.024 0.44
39_M 170_V 1.023 0.44
43_A 105_V 1.021 0.44
114_S 152_L 1.017 0.44
82_K 128_Q 1.016 0.44
76_A 96_T 1.014 0.43
60_L 134_V 1.011 0.43
33_S 36_E 1.008 0.43
33_S 71_L 1.004 0.42
131_I 134_V 1.004 0.42
58_Q 63_R 1.003 0.42
106_I 150_Y 1.001 0.42
93_K 125_E 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1uv7A20.550699.90.571Contact Map0.345
2rjzA20.629270.70.926Contact Map0.238
2w7vA20.4663350.94Contact Map0.3
4e9jA20.365223.80.945Contact Map0.541
2kogA10.286514.70.95Contact Map0.299
2rddB10.207914.20.95Contact Map0.293
2cqxA10.24729.10.955Contact Map0.139
1x2mA10.247270.957Contact Map0.116
4g9iA60.56.60.957Contact Map0.108
3hd7A20.28655.90.958Contact Map0.485
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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