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OPENSEQ.org
SSUD - Alkanesulfonate monooxygenase
UniProt: P80645 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13706
Length: 381 (351)
Sequences: 5168
Seq/Len: 14.72
SSUD
Paralog alert: 0.65 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: RUTA SSUD YHBW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
236_N 311_T 7.012 1.00
236_N 308_D 3.691 1.00
37_Q 68_V 3.442 1.00
151_N 156_H 3.389 1.00
133_A 189_E 3.336 1.00
341_V 345_L 3.107 1.00
38_A 41_R 2.89 1.00
130_E 153_K 2.883 1.00
40_D 71_R 2.849 1.00
235_T 238_E 2.804 1.00
42_L 342_G 2.729 1.00
62_A 74_F 2.706 1.00
348_L 351_V 2.692 1.00
184_Q 210_Q 2.682 1.00
310_P 348_L 2.644 1.00
38_A 339_Y 2.628 1.00
208_I 224_F 2.621 1.00
315_R 318_E 2.6 1.00
308_D 311_T 2.517 1.00
236_N 240_W 2.491 1.00
188_A 214_K 2.457 1.00
209_E 213_A 2.417 1.00
237_D 241_Q 2.37 1.00
317_N 321_A 2.363 1.00
185_E 214_K 2.357 1.00
234_E 344_L 2.351 1.00
210_Q 214_K 2.326 1.00
205_K 209_E 2.284 1.00
30_G 100_N 2.26 1.00
124_D 127_E 2.233 1.00
233_R 238_E 2.224 1.00
339_Y 343_E 2.169 1.00
127_E 153_K 2.121 1.00
37_Q 41_R 2.113 1.00
33_Q 37_Q 2.066 1.00
208_I 212_R 2.04 1.00
213_A 217_A 2.036 1.00
33_Q 68_V 2.018 1.00
313_A 348_L 1.976 1.00
244_E 248_S 1.954 1.00
66_I 99_S 1.95 1.00
73_K 104_L 1.937 1.00
134_E 152_G 1.936 1.00
215_A 222_I 1.934 1.00
310_P 314_A 1.889 1.00
317_N 320_A 1.867 1.00
65_M 74_F 1.85 1.00
141_R 148_V 1.846 1.00
130_E 154_H 1.809 1.00
336_E 339_Y 1.785 1.00
34_Q 37_Q 1.782 1.00
36_A 65_M 1.766 1.00
149_D 159_G 1.758 1.00
137_Q 190_Q 1.758 1.00
66_I 74_F 1.754 1.00
185_E 217_A 1.71 1.00
43_G 350_D 1.706 1.00
226_I 324_I 1.694 1.00
96_D 101_G 1.685 1.00
117_A 158_R 1.673 1.00
234_E 238_E 1.667 1.00
38_A 42_L 1.66 1.00
36_A 47_V 1.626 1.00
92_A 103_A 1.612 1.00
238_E 242_A 1.612 1.00
141_R 145_R 1.602 1.00
48_L 75_L 1.574 1.00
144_Q 171_Y 1.565 1.00
138_V 157_V 1.559 1.00
206_E 209_E 1.552 1.00
41_R 70_Q 1.547 1.00
47_V 72_L 1.541 1.00
137_Q 150_F 1.529 1.00
188_A 218_H 1.499 1.00
40_D 70_Q 1.482 1.00
137_Q 141_R 1.479 1.00
232_V 312_V 1.469 1.00
309_G 340_R 1.462 1.00
305_L 312_V 1.45 1.00
318_E 321_A 1.448 1.00
176_F 183_A 1.433 1.00
57_D 60_L 1.427 1.00
127_E 130_E 1.407 0.99
232_V 340_R 1.406 0.99
39_A 338_A 1.403 0.99
228_L 316_I 1.399 0.99
340_R 344_L 1.398 0.99
311_T 314_A 1.398 0.99
346_F 350_D 1.391 0.99
185_E 218_H 1.384 0.99
127_E 154_H 1.38 0.99
238_E 241_Q 1.362 0.99
185_E 189_E 1.355 0.99
223_R 325_D 1.348 0.99
75_L 104_L 1.337 0.99
107_L 136_T 1.331 0.99
285_E 288_P 1.329 0.99
33_Q 64_S 1.298 0.99
242_A 340_R 1.296 0.99
140_R 171_Y 1.293 0.99
34_Q 38_A 1.29 0.99
113_P 117_A 1.289 0.99
151_N 158_R 1.28 0.99
83_T 91_Q 1.268 0.99
149_D 158_R 1.268 0.99
133_A 190_Q 1.26 0.99
29_H 98_L 1.253 0.99
34_Q 335_L 1.253 0.99
178_G 194_Y 1.246 0.98
49_I 65_M 1.244 0.98
214_K 217_A 1.242 0.98
138_V 150_F 1.239 0.98
140_R 174_L 1.238 0.98
133_A 137_Q 1.236 0.98
235_T 239_A 1.236 0.98
232_V 309_G 1.222 0.98
96_D 168_Q 1.217 0.98
138_V 141_R 1.215 0.98
30_G 34_Q 1.212 0.98
44_Y 342_G 1.21 0.98
100_N 167_I 1.209 0.98
234_E 336_E 1.206 0.98
138_V 155_I 1.206 0.98
175_Y 225_G 1.205 0.98
136_T 190_Q 1.202 0.98
233_R 239_A 1.202 0.98
141_R 150_F 1.201 0.98
241_Q 244_E 1.197 0.98
57_D 91_Q 1.19 0.98
49_I 62_A 1.186 0.98
336_E 340_R 1.183 0.98
30_G 33_Q 1.182 0.98
42_L 338_A 1.181 0.98
184_Q 214_K 1.174 0.98
344_L 348_L 1.171 0.98
66_I 103_A 1.171 0.98
36_A 69_T 1.17 0.97
314_A 317_N 1.17 0.97
36_A 72_L 1.162 0.97
314_A 318_E 1.153 0.97
22_E 25_R 1.144 0.97
134_E 153_K 1.141 0.97
243_A 306_V 1.141 0.97
329_L 341_V 1.139 0.97
38_A 335_L 1.139 0.97
348_L 352_A 1.137 0.97
140_R 190_Q 1.136 0.97
210_Q 213_A 1.131 0.97
64_S 67_P 1.13 0.97
6_F 46_G 1.122 0.97
56_E 94_T 1.119 0.96
189_E 218_H 1.117 0.96
64_S 98_L 1.116 0.96
17_Y 20_T 1.109 0.96
140_R 192_D 1.103 0.96
241_Q 245_R 1.087 0.96
313_A 317_N 1.084 0.96
335_L 339_Y 1.083 0.96
243_A 247_I 1.082 0.96
40_D 69_T 1.082 0.96
95_L 103_A 1.076 0.95
126_S 182_V 1.068 0.95
181_D 214_K 1.068 0.95
194_Y 211_V 1.066 0.95
41_R 339_Y 1.065 0.95
45_T 350_D 1.041 0.94
185_E 213_A 1.036 0.94
268_V 271_Q 1.024 0.93
203_L 206_E 1.022 0.93
157_V 160_A 1.018 0.93
201_P 318_E 1.014 0.93
307_G 312_V 1.006 0.93
311_T 315_R 1.002 0.92
230_V 341_V 1.001 0.92
92_A 105_F 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nqkA111000.244Contact Map0.705
3raoA20.88981000.337Contact Map0.735
2wgkA20.8741000.342Contact Map0.669
3sdoA20.99211000.344Contact Map0.663
1lucA10.88191000.348Contact Map0.64
1ezwA10.85831000.351Contact Map0.692
1tvlA10.9791000.353Contact Map0.678
3b9oA20.97111000.354Contact Map0.779
2i7gA20.88191000.361Contact Map0.748
1lucB10.80581000.362Contact Map0.625
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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