May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
FOCB - Probable formate transporter 2
UniProt: P77733 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14220
Length: 282 (271)
Sequences: 1014
Seq/Len: 3.74
FOCB
Paralog alert: 0.56 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: FOCA FOCB NIRC YFDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
164_V 263_I 6.896 1.00
164_V 259_L 4.694 1.00
259_L 263_I 3.572 1.00
38_A 119_G 3.059 1.00
99_K 106_W 2.998 1.00
163_S 257_V 2.83 1.00
39_M 126_C 2.791 1.00
35_F 119_G 2.757 1.00
117_A 258_M 2.484 1.00
160_F 256_P 2.322 1.00
188_C 192_V 2.293 1.00
51_F 200_L 2.171 1.00
46_A 127_F 2.104 1.00
75_T 195_I 2.102 1.00
113_A 262_I 1.965 1.00
79_I 191_I 1.945 1.00
216_I 249_F 1.827 0.99
172_L 268_L 1.802 0.99
245_T 248_H 1.764 0.99
84_C 179_W 1.646 0.99
80_L 176_L 1.641 0.99
89_F 93_V 1.635 0.99
150_H 153_E 1.587 0.98
35_F 115_L 1.582 0.98
117_A 254_L 1.566 0.98
117_A 209_C 1.549 0.98
158_H 163_S 1.549 0.98
47_I 172_L 1.52 0.97
65_L 69_V 1.518 0.97
209_C 258_M 1.517 0.97
118_C 122_A 1.509 0.97
27_I 104_I 1.506 0.97
121_L 213_L 1.505 0.97
89_F 262_I 1.501 0.97
34_V 115_L 1.482 0.97
186_S 189_D 1.477 0.97
158_H 166_L 1.472 0.97
92_S 112_N 1.472 0.97
77_G 202_V 1.463 0.97
129_L 133_F 1.447 0.96
51_F 199_T 1.442 0.96
114_L 118_C 1.437 0.96
122_A 125_A 1.409 0.96
184_G 189_D 1.394 0.95
24_A 103_V 1.386 0.95
55_V 69_V 1.378 0.95
39_M 122_A 1.368 0.95
168_I 263_I 1.364 0.94
180_M 193_A 1.364 0.94
23_A 98_A 1.363 0.94
168_I 267_V 1.359 0.94
35_F 122_A 1.349 0.94
52_Y 70_G 1.34 0.94
130_L 169_M 1.302 0.92
47_I 127_F 1.298 0.92
99_K 104_I 1.286 0.92
170_C 210_I 1.286 0.92
212_N 253_N 1.276 0.91
11_L 14_R 1.272 0.91
72_L 195_I 1.262 0.91
160_F 163_S 1.261 0.91
82_A 194_M 1.26 0.91
110_L 114_L 1.243 0.90
258_M 262_I 1.24 0.90
171_N 201_F 1.236 0.90
43_V 46_A 1.233 0.89
128_S 218_F 1.233 0.89
109_W 113_A 1.229 0.89
82_A 178_L 1.201 0.88
72_L 199_T 1.199 0.88
159_T 162_E 1.192 0.87
43_V 172_L 1.191 0.87
234_A 238_A 1.177 0.86
99_K 109_W 1.17 0.86
34_V 111_I 1.167 0.86
247_S 251_T 1.156 0.85
44_F 80_L 1.149 0.84
160_F 164_V 1.143 0.84
37_M 179_W 1.139 0.84
83_V 187_L 1.136 0.84
41_A 89_F 1.135 0.83
87_S 92_S 1.129 0.83
265_G 270_S 1.124 0.83
201_F 212_N 1.114 0.82
40_S 44_F 1.112 0.82
28_A 108_T 1.108 0.81
160_F 259_L 1.108 0.81
121_L 125_A 1.107 0.81
210_I 213_L 1.102 0.81
228_P 232_Q 1.101 0.81
107_R 111_I 1.097 0.80
99_K 102_G 1.095 0.80
110_L 255_L 1.09 0.80
89_F 258_M 1.086 0.80
210_I 272_C 1.077 0.79
269_V 273_Y 1.077 0.79
84_C 273_Y 1.073 0.78
167_G 258_M 1.073 0.78
44_F 86_T 1.073 0.78
129_L 221_A 1.071 0.78
128_S 221_A 1.066 0.78
183_C 187_L 1.059 0.77
235_H 238_A 1.057 0.77
155_K 211_A 1.055 0.77
148_V 218_F 1.054 0.77
74_F 212_N 1.051 0.76
161_T 165_S 1.051 0.76
106_W 110_L 1.05 0.76
209_C 254_L 1.05 0.76
86_T 273_Y 1.043 0.76
130_L 165_S 1.033 0.75
194_M 198_I 1.033 0.75
47_I 210_I 1.03 0.74
11_L 15_K 1.025 0.74
214_F 217_P 1.007 0.72
167_G 256_P 1.004 0.72
45_M 49_F 1.003 0.72
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kcuA511000.038Contact Map0.756
3klyA50.98941000.05Contact Map0.731
3tdsE50.90781000.131Contact Map0.783
4fc4A100.88651000.157Contact Map0.749
3zojA10.875971.40.947Contact Map0.466
3iyzA10.879431.70.959Contact Map0.032
3cn5A10.879420.70.962Contact Map0.396
3llqA20.868816.40.964Contact Map0.399
1j4nA10.812110.50.967Contact Map0.475
2o9gA10.80857.10.97Contact Map0.357
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0474 seconds.