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YKGA - Putative HTH-type transcriptional regulator YkgA
UniProt: P77601 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13381
Length: 239 (222)
Sequences: 695
Seq/Len: 3.13
YKGA
Paralog alert: 0.44 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ROB YKGA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
28_N 31_H 3.625 1.00
25_I 65_I 2.324 1.00
53_F 64_Y 2.31 1.00
21_L 49_I 2.285 1.00
95_S 98_S 2.235 1.00
148_P 221_E 2.138 1.00
76_L 90_S 2.101 1.00
146_E 226_R 2.039 1.00
89_L 96_Q 2.022 1.00
146_E 223_T 1.942 1.00
26_E 64_Y 1.864 0.99
82_K 87_I 1.767 0.99
36_E 46_R 1.727 0.99
225_T 229_Y 1.691 0.98
153_S 206_E 1.671 0.98
37_D 40_Q 1.66 0.98
30_E 72_R 1.614 0.98
64_Y 68_R 1.558 0.97
87_I 115_R 1.545 0.97
80_T 115_R 1.538 0.97
38_I 84_M 1.522 0.96
96_Q 100_S 1.512 0.96
83_S 86_D 1.49 0.96
95_S 129_F 1.47 0.95
76_L 91_L 1.464 0.95
70_L 106_L 1.431 0.94
76_L 82_K 1.417 0.94
26_E 68_R 1.414 0.94
44_Y 47_R 1.393 0.93
21_L 41_K 1.388 0.93
169_V 173_R 1.378 0.93
64_Y 93_F 1.376 0.93
49_I 102_E 1.375 0.93
34_S 37_D 1.361 0.92
24_W 32_P 1.358 0.92
47_R 205_V 1.355 0.92
71_C 151_G 1.353 0.92
144_F 147_T 1.35 0.92
133_Q 137_T 1.348 0.92
21_L 38_I 1.33 0.91
62_G 97_Q 1.33 0.91
65_I 84_M 1.324 0.91
147_T 224_T 1.319 0.91
114_Y 123_A 1.311 0.90
71_C 107_F 1.302 0.90
141_L 152_N 1.296 0.90
73_A 99_F 1.291 0.89
144_F 229_Y 1.25 0.87
100_S 110_S 1.249 0.87
85_L 89_L 1.223 0.86
80_T 87_I 1.222 0.86
199_S 202_L 1.215 0.85
177_A 180_M 1.213 0.85
189_F 207_T 1.209 0.85
25_I 38_I 1.208 0.85
153_S 220_K 1.205 0.84
151_G 208_F 1.202 0.84
156_Y 182_N 1.201 0.84
24_W 28_N 1.193 0.84
17_I 21_L 1.19 0.83
24_W 29_L 1.181 0.83
58_H 69_R 1.176 0.82
28_N 38_I 1.167 0.82
54_R 60_P 1.147 0.80
194_E 197_T 1.144 0.80
194_E 198_K 1.138 0.79
35_I 38_I 1.132 0.79
17_I 43_G 1.129 0.79
148_P 223_T 1.127 0.79
173_R 177_A 1.126 0.78
60_P 78_R 1.117 0.78
15_Q 164_S 1.116 0.78
183_F 192_T 1.107 0.77
83_S 96_Q 1.1 0.76
84_M 115_R 1.097 0.76
24_W 33_I 1.091 0.75
18_L 57_M 1.091 0.75
35_I 46_R 1.091 0.75
35_I 61_L 1.089 0.75
33_I 70_L 1.083 0.75
173_R 181_K 1.073 0.74
93_F 104_K 1.065 0.73
57_M 60_P 1.064 0.73
63_E 147_T 1.058 0.72
70_L 100_S 1.054 0.72
49_I 112_R 1.051 0.71
23_E 128_S 1.049 0.71
149_I 208_F 1.048 0.71
20_Q 29_L 1.036 0.70
77_V 84_M 1.034 0.70
36_E 89_L 1.033 0.70
30_E 88_A 1.032 0.69
59_V 67_K 1.032 0.69
123_A 156_Y 1.025 0.69
190_V 198_K 1.024 0.69
55_N 100_S 1.023 0.68
151_G 222_W 1.021 0.68
12_M 176_L 1.021 0.68
89_L 149_I 1.02 0.68
38_I 41_K 1.019 0.68
25_I 29_L 1.017 0.68
43_G 47_R 1.014 0.67
41_K 226_R 1.014 0.67
12_M 17_I 1.013 0.67
145_P 153_S 1.012 0.67
44_Y 75_I 1.01 0.67
61_L 104_K 1.007 0.67
192_T 195_P 1.004 0.66
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1d5yA40.94141000.449Contact Map0.465
4fe7A10.51461000.613Contact Map0.551
3gbgA10.50631000.617Contact Map0.448
1bl0A10.53971000.619Contact Map0.483
3oioA10.472899.90.623Contact Map0.511
3oouA10.451999.90.626Contact Map0.539
2k9sA10.443599.90.626Contact Map0.408
3mn2A20.443599.90.626Contact Map0.504
3w6vA10.518899.90.628Contact Map0.523
3lsgA50.426899.90.63Contact Map0.622
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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