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YGAV - Probable HTH-type transcriptional regulator YgaV
UniProt: P77295 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13524
Length: 99 (90)
Sequences: 6005
Seq/Len: 66.72

YGAV
Paralog alert: 0.75 [within 20: 0.14] - ratio of genomes with paralogs
Cluster includes: ARSR YGAV
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
69_D 82_K 3.07 1.00
70_S 77_I 3.024 1.00
69_D 80_S 2.679 1.00
38_G 71_Q 2.536 1.00
63_R 70_S 2.128 1.00
72_R 77_I 2.049 1.00
38_G 80_S 2.03 1.00
51_S 54_A 1.84 1.00
15_A 27_L 1.816 1.00
32_M 47_I 1.784 1.00
20_A 65_E 1.741 1.00
45_T 52_A 1.727 1.00
16_A 64_D 1.599 1.00
29_I 55_T 1.596 1.00
12_E 24_P 1.586 1.00
45_T 55_T 1.544 1.00
32_M 39_T 1.536 1.00
29_I 44_L 1.518 1.00
73_D 78_L 1.486 1.00
54_A 57_Q 1.449 1.00
60_A 64_D 1.443 1.00
25_K 50_L 1.412 1.00
41_A 79_Y 1.398 0.99
30_L 67_L 1.37 0.99
23_H 57_Q 1.362 0.99
30_L 81_I 1.359 0.99
40_S 76_R 1.354 0.99
59_L 68_I 1.344 0.99
66_G 82_K 1.319 0.99
40_S 43_E 1.278 0.99
36_S 39_T 1.239 0.98
11_A 31_C 1.217 0.98
43_E 46_R 1.209 0.98
39_T 43_E 1.204 0.98
50_L 55_T 1.204 0.98
73_D 76_R 1.185 0.98
59_L 79_Y 1.175 0.98
87_N 91_A 1.163 0.97
39_T 47_I 1.159 0.97
20_A 61_R 1.156 0.97
61_R 64_D 1.144 0.97
61_R 65_E 1.144 0.97
15_A 24_P 1.116 0.96
38_G 78_L 1.113 0.96
40_S 78_L 1.104 0.96
71_Q 78_L 1.099 0.96
85_A 88_A 1.08 0.95
28_L 32_M 1.06 0.95
32_M 44_L 1.054 0.95
71_Q 80_S 1.052 0.95
11_A 28_L 1.045 0.94
19_K 22_S 1.04 0.94
41_A 59_L 1.028 0.94
33_L 68_I 1.019 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2kkoA20.989999.60.377Contact Map0.738
3cuoA4199.60.381Contact Map0.883
3pqkA60.979899.60.389Contact Map0.854
1r1tA20.989999.60.401Contact Map0.854
3jthA20.979899.60.405Contact Map0.905
1u2wA4199.60.414Contact Map0.867
4g6qA20.959699.50.417Contact Map0.783
1r1uA40.989999.50.421Contact Map0.806
2jscA20.959699.50.422Contact Map0.649
2zkzA40.969799.50.426Contact Map0.855

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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