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OPENSEQ.org

YKGE - Uncharacterized protein YkgE
UniProt: P77252 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13582
Length: 239 (238)
Sequences: 3507
Seq/Len: 14.74

YKGE
Paralog alert: 0.65 [within 20: 0.07] - ratio of genomes with paralogs
Cluster includes: GLCF GLPC YKGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
131_R 161_E 3.983 1.00
21_D 234_E 3.225 1.00
131_R 163_L 3.113 1.00
230_M 238_S 3.097 1.00
24_L 237_M 3.048 1.00
2_N 32_R 2.936 1.00
41_C 80_C 2.733 1.00
111_L 233_A 2.605 1.00
116_V 152_T 2.562 1.00
51_Y 54_E 2.546 1.00
17_R 234_E 2.387 1.00
136_P 151_L 2.312 1.00
165_F 197_L 2.287 1.00
11_G 19_A 2.245 1.00
166_A 199_E 2.177 1.00
67_E 100_R 2.166 1.00
75_S 81_T 2.133 1.00
22_S 76_P 2.083 1.00
9_C 41_C 2.069 1.00
85_K 113_S 2.05 1.00
190_V 219_R 1.974 1.00
133_V 165_F 1.919 1.00
42_C 80_C 1.88 1.00
151_L 164_T 1.866 1.00
5_F 76_P 1.853 1.00
206_I 235_V 1.8 1.00
64_A 97_W 1.794 1.00
31_C 114_F 1.774 1.00
9_C 80_C 1.764 1.00
132_A 235_V 1.74 1.00
167_E 196_H 1.738 1.00
18_M 234_E 1.733 1.00
190_V 215_N 1.706 1.00
3_V 114_F 1.703 1.00
109_Q 117_N 1.701 1.00
22_S 111_L 1.695 1.00
152_T 155_K 1.694 1.00
77_A 209_D 1.666 1.00
47_I 83_A 1.631 1.00
195_A 223_E 1.63 1.00
60_K 64_A 1.615 1.00
2_N 34_N 1.605 1.00
109_Q 113_S 1.601 1.00
132_A 160_L 1.574 1.00
102_A 106_A 1.561 1.00
131_R 203_E 1.507 1.00
204_Y 230_M 1.501 1.00
130_G 203_E 1.496 1.00
23_V 33_V 1.468 1.00
9_C 42_C 1.463 1.00
59_M 87_Y 1.446 1.00
44_Q 79_S 1.437 1.00
40_G 61_N 1.38 0.99
132_A 206_I 1.38 0.99
112_T 232_I 1.374 0.99
137_S 207_G 1.367 0.99
230_M 234_E 1.362 0.99
99_S 103_K 1.348 0.99
8_T 77_A 1.317 0.99
197_L 205_L 1.306 0.99
73_I 104_V 1.294 0.99
3_V 33_V 1.28 0.99
129_Q 161_E 1.272 0.99
23_V 27_E 1.27 0.99
104_V 108_M 1.269 0.99
208_A 232_I 1.259 0.99
198_M 225_Q 1.259 0.99
64_A 100_R 1.25 0.99
230_M 235_V 1.242 0.98
25_L 236_L 1.241 0.98
195_A 199_E 1.234 0.98
99_S 102_A 1.231 0.98
56_I 60_K 1.226 0.98
191_K 195_A 1.216 0.98
190_V 194_V 1.208 0.98
71_D 107_R 1.205 0.98
44_Q 48_N 1.202 0.98
172_C 212_C 1.187 0.98
130_G 204_Y 1.181 0.98
167_E 192_E 1.175 0.98
109_Q 114_F 1.147 0.97
117_N 149_E 1.145 0.97
101_A 105_A 1.14 0.97
28_K 237_M 1.14 0.97
115_I 236_L 1.136 0.97
64_A 67_E 1.129 0.97
146_V 149_E 1.122 0.97
133_V 200_V 1.117 0.96
152_T 156_N 1.103 0.96
155_K 161_E 1.1 0.96
74_I 114_F 1.098 0.96
81_T 144_L 1.098 0.96
155_K 162_L 1.093 0.96
134_Y 150_P 1.092 0.96
93_D 98_A 1.086 0.96
220_L 225_Q 1.084 0.96
140_L 146_V 1.07 0.95
154_L 206_I 1.067 0.95
81_T 108_M 1.058 0.95
141_A 147_K 1.055 0.95
98_A 102_A 1.053 0.95
197_L 227_V 1.049 0.94
126_A 157_V 1.044 0.94
26_L 74_I 1.041 0.94
196_H 199_E 1.039 0.94
75_S 84_V 1.037 0.94
157_V 160_L 1.035 0.94
4_N 69_N 1.025 0.93
3_V 74_I 1.02 0.93
205_L 227_V 1.019 0.93
113_S 146_V 1.017 0.93
194_V 220_L 1.017 0.93
88_P 105_A 1.01 0.93
34_N 69_N 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3kwlA10.92891000.261Contact Map0.544
3cf4A10.774199.90.548Contact Map0.088
3c8yA10.891297.60.859Contact Map0.115
2jfzA20.4164.20.93Contact Map0.462
2gzmA40.422656.10.933Contact Map0.549
3outA30.439347.80.937Contact Map0.423
3qvlA20.84145.60.938Contact Map0.394
1b73A10.4144.40.938Contact Map0.526
1jflA20.870340.50.939Contact Map0.526
2eq5A40.447737.50.94Contact Map0.555

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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