May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org

MDTC - Multidrug resistance protein MdtC
UniProt: P76399 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14058
Length: 1025 (1011)
Sequences: 7824
Seq/Len: 7.74

MDTC
Paralog alert: 0.74 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: ACRB ACRD ACRF CUSA MDTB MDTC MDTF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
239_A 242_Q 4.362 1.00
938_T 941_E 4.347 1.00
305_P 308_Q 4.207 1.00
303_K 306_E 4.115 1.00
242_Q 257_G 3.991 1.00
64_A 89_T 3.953 1.00
707_V 785_Q 3.866 1.00
49_A 89_T 3.709 1.00
894_A 988_G 3.639 1.00
243_P 257_G 3.428 1.00
518_S 999_Y 3.341 1.00
574_A 577_G 3.34 1.00
298_D 328_R 3.326 1.00
579_L 607_G 3.319 1.00
246_I 259_V 3.294 1.00
242_Q 262_V 3.229 1.00
709_D 783_K 3.172 1.00
5_A 9_Y 3.16 1.00
520_K 944_F 3.15 1.00
713_M 723_A 3.14 1.00
708_Y 713_M 3.11 1.00
144_L 158_A 3.041 1.00
737_S 748_V 3.039 1.00
194_L 199_V 2.916 1.00
189_L 204_V 2.913 1.00
60_A 800_A 2.898 1.00
308_Q 316_D 2.892 1.00
77_V 93_L 2.885 1.00
150_S 153_E 2.85 1.00
669_D 672_A 2.842 1.00
256_L 262_V 2.836 1.00
276_N 594_N 2.831 1.00
419_K 422_Q 2.829 1.00
301_R 322_D 2.801 1.00
672_A 675_E 2.799 1.00
418_M 426_Q 2.74 1.00
719_D 722_A 2.719 1.00
187_V 208_V 2.695 1.00
339_I 343_A 2.67 1.00
169_I 299_S 2.643 1.00
165_T 303_K 2.617 1.00
709_D 712_T 2.589 1.00
154_L 315_I 2.551 1.00
372_G 473_I 2.534 1.00
683_K 686_T 2.524 1.00
238_A 242_Q 2.505 1.00
64_A 84_S 2.498 1.00
675_E 679_K 2.497 1.00
190_N 193_A 2.444 1.00
676_W 834_V 2.416 1.00
274_M 583_M 2.397 1.00
78_S 96_D 2.362 1.00
665_L 680_I 2.36 1.00
576_R 580_Q 2.339 1.00
586_I 630_L 2.314 1.00
706_L 782_A 2.308 1.00
898_F 984_I 2.307 1.00
937_L 945_Q 2.3 1.00
615_P 618_E 2.268 1.00
205_R 750_M 2.246 1.00
588_D 633_K 2.237 1.00
157_F 315_I 2.237 1.00
336_Q 340_I 2.235 1.00
78_S 94_Q 2.235 1.00
194_L 259_V 2.211 1.00
708_Y 723_A 2.177 1.00
876_H 929_L 2.167 1.00
67_L 71_L 2.159 1.00
622_T 625_Q 2.158 1.00
239_A 243_P 2.152 1.00
683_K 827_Q 2.145 1.00
812_K 820_A 2.143 1.00
295_Q 299_S 2.131 1.00
524_N 940_Q 2.117 1.00
189_L 201_L 2.109 1.00
241_Y 256_L 2.103 1.00
687_L 820_A 2.095 1.00
535_G 539_L 2.094 1.00
761_S 764_E 2.079 1.00
562_G 611_I 2.074 1.00
376_A 469_V 2.072 1.00
59_M 63_V 2.072 1.00
57_E 61_S 2.066 1.00
813_S 816_D 2.023 1.00
516_G 948_L 2.015 1.00
692_D 807_N 2.012 1.00
707_V 783_K 2.011 1.00
147_D 316_D 2.004 1.00
819_A 822_D 1.998 1.00
67_L 91_I 1.992 1.00
566_A 570_I 1.989 1.00
183_P 264_D 1.988 1.00
718_I 768_V 1.976 1.00
208_V 244_L 1.962 1.00
969_V 987_V 1.957 1.00
690_L 693_V 1.956 1.00
409_N 430_E 1.955 1.00
382_F 465_V 1.947 1.00
681_R 685_A 1.943 1.00
684_L 821_I 1.936 1.00
777_P 780_Y 1.931 1.00
621_E 629_R 1.929 1.00
822_D 846_Q 1.928 1.00
705_N 787_A 1.917 1.00
332_E 336_Q 1.911 1.00
764_E 779_S 1.908 1.00
521_W 524_N 1.906 1.00
943_I 1006_L 1.901 1.00
413_H 430_E 1.881 1.00
12_V 868_G 1.877 1.00
162_L 307_L 1.877 1.00
629_R 633_K 1.869 1.00
589_D 629_R 1.867 1.00
71_L 91_I 1.865 1.00
521_W 525_H 1.864 1.00
365_S 477_V 1.856 1.00
690_L 817_A 1.844 1.00
188_G 263_T 1.842 1.00
525_H 528_L 1.821 1.00
422_Q 426_Q 1.817 1.00
593_D 614_K 1.817 1.00
199_V 203_D 1.814 1.00
184_A 749_V 1.774 1.00
144_L 162_L 1.772 1.00
931_A 934_H 1.77 1.00
200_S 203_D 1.768 1.00
682_K 686_T 1.763 1.00
205_R 209_S 1.763 1.00
932_Q 1005_Y 1.755 1.00
679_K 682_K 1.745 1.00
661_Y 806_F 1.743 1.00
712_T 715_R 1.732 1.00
718_I 781_F 1.732 1.00
581_D 584_K 1.727 1.00
510_A 513_Q 1.721 1.00
723_A 781_F 1.719 1.00
681_R 693_V 1.717 1.00
929_L 933_R 1.717 1.00
189_L 194_L 1.715 1.00
472_G 476_L 1.715 1.00
147_D 278_K 1.712 1.00
212_N 737_S 1.705 1.00
298_D 302_A 1.704 1.00
26_I 30_R 1.704 1.00
237_T 240_E 1.689 1.00
182_L 267_Q 1.689 1.00
149_Y 314_A 1.689 1.00
586_I 592_V 1.688 1.00
71_L 93_L 1.688 1.00
295_Q 298_D 1.687 1.00
676_W 679_K 1.685 1.00
677_E 802_S 1.682 1.00
678_P 681_R 1.681 1.00
412_R 949_L 1.679 1.00
628_D 632_V 1.677 1.00
812_K 816_D 1.669 1.00
564_I 582_F 1.668 1.00
413_H 418_M 1.665 1.00
261_T 753_D 1.665 1.00
299_S 302_A 1.664 1.00
768_V 781_F 1.66 1.00
63_V 123_M 1.659 1.00
591_A 621_E 1.657 1.00
940_Q 1006_L 1.653 1.00
10_R 872_E 1.652 1.00
49_A 64_A 1.645 1.00
31_M 378_Y 1.645 1.00
206_T 209_S 1.645 1.00
191_P 756_Y 1.641 1.00
172_V 285_I 1.638 1.00
80_M 93_L 1.631 1.00
22_T 371_I 1.626 1.00
64_A 82_S 1.621 1.00
515_Y 947_C 1.618 1.00
816_D 819_A 1.612 1.00
194_L 204_V 1.61 1.00
156_D 746_Y 1.607 1.00
560_L 611_I 1.606 1.00
190_N 261_T 1.604 1.00
736_I 750_M 1.603 1.00
526_T 1006_L 1.599 1.00
681_R 695_S 1.596 1.00
753_D 756_Y 1.589 1.00
689_E 820_A 1.585 1.00
202_D 206_T 1.584 1.00
549_K 815_S 1.583 1.00
274_M 576_R 1.58 1.00
409_N 412_R 1.579 1.00
530_G 534_L 1.578 1.00
68_E 795_H 1.575 1.00
631_R 692_D 1.575 1.00
443_V 472_G 1.568 1.00
759_D 762_A 1.567 1.00
580_Q 584_K 1.565 1.00
584_K 588_D 1.565 1.00
204_V 259_V 1.563 1.00
579_L 597_G 1.56 1.00
680_I 825_M 1.552 1.00
682_K 685_A 1.542 1.00
200_S 769_I 1.542 1.00
376_A 380_C 1.541 1.00
591_A 626_I 1.54 1.00
510_A 514_G 1.539 1.00
465_V 469_V 1.533 1.00
614_K 618_E 1.529 1.00
145_T 318_Q 1.528 1.00
713_M 718_I 1.525 1.00
343_A 347_L 1.525 1.00
589_D 633_K 1.525 1.00
585_I 633_K 1.523 1.00
47_V 71_L 1.521 1.00
570_I 574_A 1.516 1.00
864_Y 877_P 1.515 1.00
333_E 336_Q 1.513 1.00
291_A 296_T 1.509 1.00
16_L 865_I 1.509 1.00
236_K 240_E 1.504 0.99
246_I 254_V 1.501 0.99
235_L 241_Y 1.498 0.99
665_L 804_I 1.496 0.99
76_G 99_R 1.493 0.99
206_T 210_N 1.49 0.99
820_A 823_R 1.489 0.99
674_R 678_P 1.487 0.99
900_A 984_I 1.486 0.99
542_W 545_I 1.483 0.99
36_P 557_T 1.479 0.99
93_L 108_V 1.477 0.99
931_A 937_L 1.472 0.99
304_L 317_L 1.472 0.99
518_S 521_W 1.469 0.99
28_G 375_A 1.469 0.99
144_L 154_L 1.465 0.99
844_V 847_E 1.457 0.99
240_E 243_P 1.455 0.99
373_T 470_A 1.452 0.99
564_I 579_L 1.447 0.99
9_Y 421_L 1.447 0.99
380_C 469_V 1.443 0.99
143_T 275_T 1.441 0.99
229_I 731_F 1.44 0.99
823_R 827_Q 1.436 0.99
84_S 89_T 1.431 0.99
582_F 634_L 1.428 0.99
413_H 416_A 1.428 0.99
71_L 108_V 1.425 0.99
883_T 921_A 1.422 0.99
531_V 535_G 1.422 0.99
579_L 599_T 1.415 0.99
677_E 695_S 1.414 0.99
100_D 103_G 1.413 0.99
931_A 945_Q 1.404 0.99
706_L 784_W 1.401 0.99
962_L 991_V 1.398 0.99
67_L 115_A 1.397 0.99
683_K 824_A 1.397 0.99
76_G 96_D 1.396 0.99
243_P 255_R 1.395 0.99
5_A 425_L 1.395 0.99
705_N 785_Q 1.393 0.99
962_L 987_V 1.393 0.99
29_F 335_E 1.391 0.99
825_M 836_G 1.39 0.99
584_K 587_R 1.388 0.99
406_V 428_T 1.387 0.99
542_W 546_S 1.387 0.99
322_D 325_P 1.386 0.99
672_A 676_W 1.382 0.99
412_R 416_A 1.382 0.99
301_R 319_I 1.382 0.99
668_D 834_V 1.381 0.99
210_N 714_A 1.381 0.99
47_V 93_L 1.379 0.99
516_G 520_K 1.377 0.99
157_F 161_Q 1.368 0.99
346_I 363_A 1.368 0.99
820_A 824_A 1.358 0.99
49_A 123_M 1.354 0.99
929_L 932_Q 1.353 0.99
822_D 826_T 1.353 0.99
197_Q 254_V 1.351 0.99
930_E 933_R 1.348 0.99
940_Q 944_F 1.347 0.99
203_D 206_T 1.345 0.99
172_V 296_T 1.344 0.99
299_S 303_K 1.342 0.99
24_C 375_A 1.342 0.99
577_G 581_D 1.341 0.99
538_A 541_I 1.332 0.98
633_K 636_K 1.332 0.98
517_K 521_W 1.328 0.98
679_K 683_K 1.328 0.98
537_I 541_I 1.327 0.98
99_R 104_A 1.326 0.98
402_D 919_K 1.326 0.98
302_A 306_E 1.325 0.98
530_G 1007_F 1.319 0.98
311_I 317_L 1.318 0.98
6_L 13_A 1.318 0.98
541_I 545_I 1.317 0.98
667_S 834_V 1.307 0.98
203_D 247_H 1.304 0.98
15_I 874_Y 1.301 0.98
21_I 372_G 1.299 0.98
566_A 575_M 1.299 0.98
589_D 626_I 1.298 0.98
193_A 197_Q 1.298 0.98
664_T 801_A 1.298 0.98
585_I 636_K 1.295 0.98
583_M 587_R 1.295 0.98
365_S 482_T 1.295 0.98
301_R 305_P 1.29 0.98
242_Q 261_T 1.288 0.98
193_A 196_N 1.287 0.98
170_D 299_S 1.287 0.98
517_K 520_K 1.286 0.98
550_T 901_P 1.283 0.98
45_I 108_V 1.28 0.98
28_G 378_Y 1.278 0.98
514_G 517_K 1.277 0.98
143_T 280_A 1.277 0.98
580_Q 583_M 1.276 0.98
632_V 635_A 1.274 0.98
939_P 943_I 1.273 0.98
824_A 827_Q 1.272 0.98
245_I 253_A 1.27 0.98
951_F 955_M 1.269 0.98
728_N 734_R 1.26 0.98
203_D 769_I 1.258 0.98
5_A 429_R 1.256 0.98
235_L 244_L 1.254 0.98
113_N 116_Q 1.252 0.97
55_S 58_T 1.249 0.97
680_I 804_I 1.248 0.97
418_M 422_Q 1.244 0.97
891_A 910_I 1.238 0.97
519_L 523_L 1.238 0.97
592_V 611_I 1.234 0.97
45_I 105_A 1.233 0.97
333_E 979_R 1.231 0.97
22_T 368_V 1.23 0.97
690_L 806_F 1.23 0.97
937_L 941_E 1.228 0.97
175_V 283_L 1.225 0.97
298_D 301_R 1.222 0.97
303_K 307_L 1.222 0.97
516_G 945_Q 1.22 0.97
664_T 796_Q 1.22 0.97
302_A 305_P 1.219 0.97
256_L 260_A 1.216 0.97
721_Q 725_S 1.216 0.97
575_M 607_G 1.211 0.97
599_T 607_G 1.211 0.97
8_I 425_L 1.209 0.97
59_M 89_T 1.208 0.97
163_A 167_S 1.206 0.97
934_H 937_L 1.206 0.97
585_I 589_D 1.205 0.97
819_A 823_R 1.205 0.97
116_Q 126_R 1.205 0.97
566_A 578_K 1.204 0.97
3_F 7_F 1.204 0.97
409_N 927_F 1.202 0.97
47_V 67_L 1.2 0.97
8_I 484_M 1.2 0.97
217_Q 231_T 1.198 0.96
410_I 486_C 1.195 0.96
917_V 993_S 1.195 0.96
666_L 801_A 1.191 0.96
60_A 795_H 1.189 0.96
578_K 581_D 1.189 0.96
663_Y 684_L 1.185 0.96
624_Q 628_D 1.184 0.96
49_A 127_P 1.182 0.96
966_L 987_V 1.18 0.96
60_A 793_V 1.18 0.96
769_I 775_A 1.179 0.96
941_E 945_Q 1.176 0.96
437_S 866_V 1.176 0.96
895_L 906_A 1.176 0.96
368_V 481_L 1.175 0.96
243_P 711_D 1.17 0.96
116_Q 125_S 1.169 0.96
930_E 934_H 1.163 0.96
306_E 309_E 1.162 0.96
426_Q 429_R 1.161 0.96
886_S 996_L 1.158 0.95
65_T 795_H 1.157 0.95
665_L 676_W 1.157 0.95
593_D 612_T 1.154 0.95
142_L 319_I 1.154 0.95
821_I 838_F 1.153 0.95
665_L 673_L 1.152 0.95
735_Q 747_K 1.151 0.95
689_E 812_K 1.15 0.95
145_T 316_D 1.148 0.95
413_H 426_Q 1.148 0.95
581_D 639_G 1.144 0.95
587_R 595_V 1.144 0.95
70_S 115_A 1.139 0.95
564_I 607_G 1.139 0.95
292_N 295_Q 1.138 0.95
48_S 88_S 1.136 0.95
536_T 889_V 1.136 0.95
595_V 609_M 1.133 0.95
683_K 828_L 1.132 0.95
903_S 906_A 1.132 0.95
662_Q 803_T 1.132 0.95
628_D 631_R 1.131 0.95
165_T 307_L 1.131 0.95
850_N 853_V 1.13 0.95
560_L 630_L 1.13 0.95
710_R 720_V 1.129 0.95
718_I 771_N 1.129 0.95
676_W 830_V 1.129 0.95
796_Q 839_A 1.128 0.95
255_R 711_D 1.128 0.95
577_G 580_Q 1.128 0.95
621_E 625_Q 1.125 0.94
535_G 538_A 1.125 0.94
230_Q 703_E 1.125 0.94
79_E 94_Q 1.124 0.94
305_P 309_E 1.122 0.94
163_A 175_V 1.121 0.94
409_N 431_V 1.119 0.94
538_A 542_W 1.115 0.94
190_N 756_Y 1.113 0.94
729_N 734_R 1.112 0.94
704_M 760_I 1.111 0.94
67_L 112_I 1.11 0.94
204_V 246_I 1.109 0.94
560_L 627_I 1.105 0.94
793_V 800_A 1.104 0.94
255_R 258_D 1.104 0.94
966_L 970_L 1.103 0.94
591_A 614_K 1.102 0.94
111_A 114_A 1.102 0.94
738_T 747_K 1.1 0.94
59_M 84_S 1.098 0.94
589_D 630_L 1.098 0.94
718_I 723_A 1.096 0.93
672_A 834_V 1.094 0.93
528_L 531_V 1.092 0.93
219_A 226_R 1.089 0.93
328_R 332_E 1.088 0.93
703_E 789_A 1.087 0.93
928_A 943_I 1.087 0.93
377_M 382_F 1.087 0.93
194_L 197_Q 1.085 0.93
241_Y 748_V 1.084 0.93
770_N 774_K 1.082 0.93
188_G 261_T 1.08 0.93
751_E 757_T 1.079 0.93
945_Q 948_L 1.079 0.93
439_S 475_L 1.078 0.93
959_L 963_F 1.078 0.93
523_L 943_I 1.077 0.93
18_S 368_V 1.076 0.93
7_F 14_T 1.076 0.93
140_M 300_I 1.074 0.93
666_L 837_S 1.074 0.93
763_L 784_W 1.073 0.92
514_G 518_S 1.07 0.92
958_T 994_Q 1.068 0.92
142_L 317_L 1.068 0.92
438_M 475_L 1.066 0.92
77_V 80_M 1.062 0.92
301_R 324_S 1.061 0.92
843_Q 847_E 1.059 0.92
155_Y 159_S 1.059 0.92
442_L 919_K 1.059 0.92
739_I 748_V 1.059 0.92
687_L 824_A 1.058 0.92
533_L 1000_T 1.058 0.92
503_G 506_R 1.057 0.92
526_T 1010_R 1.053 0.92
522_V 1003_V 1.053 0.92
522_V 999_Y 1.05 0.91
799_S 835_R 1.05 0.91
144_L 317_L 1.049 0.91
409_N 413_H 1.049 0.91
308_Q 317_L 1.047 0.91
958_T 962_L 1.047 0.91
241_Y 262_V 1.046 0.91
297_V 324_S 1.046 0.91
581_D 585_I 1.044 0.91
578_K 637_E 1.044 0.91
207_A 244_L 1.044 0.91
527_R 531_V 1.041 0.91
13_A 869_I 1.04 0.91
188_G 753_D 1.038 0.91
204_V 750_M 1.038 0.91
513_Q 517_K 1.036 0.91
245_I 255_R 1.035 0.91
364_V 485_M 1.034 0.91
900_A 980_Q 1.033 0.90
621_E 626_I 1.031 0.90
762_A 765_K 1.03 0.90
18_S 481_L 1.03 0.90
534_L 538_A 1.029 0.90
155_Y 180_S 1.029 0.90
79_E 797_G 1.029 0.90
927_F 949_L 1.025 0.90
562_G 586_I 1.023 0.90
770_N 773_G 1.022 0.90
539_L 543_L 1.022 0.90
871_Y 922_I 1.021 0.90
83_S 92_I 1.02 0.90
962_L 990_L 1.017 0.90
797_G 837_S 1.016 0.89
158_A 283_L 1.015 0.89
663_Y 836_G 1.013 0.89
165_T 310_T 1.009 0.89
955_M 959_L 1.008 0.89
546_S 896_E 1.008 0.89
373_T 469_V 1.004 0.89
9_Y 425_L 1.003 0.89
661_Y 821_I 1.003 0.89
554_E 624_Q 1.003 0.89
184_A 267_Q 1 0.88
99_R 107_D 1 0.88
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4k0jA60.98341000.218Contact Map0.769
3w9iA60.99121000.278Contact Map0.859
4dx5A30.99121000.28Contact Map0.802
3ne5A10.98241000.29Contact Map0.705
3aqpA20.70731000.742Contact Map0.439
2ew9A10.145474.60.983Contact Map0.585
3cq1A10.097654.70.985Contact Map0.505
1uwdA10.096649.40.986Contact Map0.574
1p6tA10.147340.70.986Contact Map0.716
2ropA10.170734.50.987Contact Map0.621

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0817 seconds.