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OPENSEQ.org
YOAA - Probable ATP-dependent helicase YoaA
UniProt: P76257 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13513
Length: 636 (628)
Sequences: 1583
Seq/Len: 2.52
YOAA
Paralog alert: 0.44 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: DING YOAA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
427_D 430_R 4.889 1.00
59_A 223_I 3.742 1.00
227_A 394_F 3.193 1.00
201_F 224_F 3.174 1.00
460_I 467_C 3.131 1.00
557_C 562_G 3.127 1.00
471_C 480_L 3.067 1.00
27_M 43_V 3.035 1.00
471_C 516_V 2.99 1.00
456_L 536_I 2.982 1.00
145_I 158_W 2.963 1.00
466_R 533_S 2.625 1.00
584_L 592_G 2.531 1.00
35_I 221_V 2.503 1.00
463_N 467_C 2.462 1.00
474_H 518_T 2.349 1.00
558_R 564_P 2.184 1.00
574_V 610_F 2.145 1.00
522_W 580_G 2.136 1.00
22_E 26_Q 2.119 1.00
21_R 24_Q 2.114 1.00
142_D 147_T 2.101 1.00
577_L 610_F 2.087 1.00
596_I 601_L 2.019 0.99
27_M 395_T 2.003 0.99
19_K 588_A 1.961 0.99
59_A 66_V 1.957 0.99
505_Q 509_S 1.941 0.99
471_C 477_M 1.922 0.99
562_G 567_E 1.914 0.99
431_Q 585_I 1.909 0.99
477_M 516_V 1.898 0.99
68_I 79_L 1.88 0.99
52_T 224_F 1.876 0.99
528_R 587_D 1.872 0.99
450_R 483_Q 1.842 0.99
493_L 513_A 1.791 0.98
100_L 194_V 1.771 0.98
579_Q 583_R 1.767 0.98
34_A 41_L 1.752 0.98
168_C 173_C 1.748 0.98
224_F 230_L 1.748 0.98
484_F 516_V 1.711 0.98
30_A 420_L 1.709 0.98
229_Q 523_E 1.705 0.98
80_Y 195_V 1.704 0.98
54_A 58_P 1.692 0.98
624_A 628_R 1.687 0.97
84_L 97_V 1.686 0.97
84_L 195_V 1.679 0.97
69_S 198_H 1.675 0.97
23_P 422_L 1.661 0.97
459_I 595_V 1.651 0.97
381_F 386_A 1.643 0.97
577_L 596_I 1.642 0.97
21_R 45_A 1.626 0.97
481_A 494_L 1.625 0.97
623_I 627_V 1.576 0.96
98_A 191_A 1.575 0.96
48_G 51_K 1.568 0.96
70_T 197_N 1.566 0.96
485_R 497_E 1.559 0.95
519_S 576_T 1.543 0.95
35_I 393_I 1.539 0.95
75_L 78_Q 1.539 0.95
64_K 220_D 1.534 0.95
583_R 586_R 1.507 0.94
581_V 594_L 1.501 0.94
466_R 490_L 1.501 0.94
563_D 566_D 1.495 0.94
75_L 101_K 1.485 0.94
42_V 412_L 1.474 0.93
579_Q 586_R 1.473 0.93
66_V 223_I 1.471 0.93
27_M 31_V 1.464 0.93
581_V 596_I 1.457 0.93
108_C 179_C 1.454 0.93
34_A 39_Q 1.453 0.93
84_L 193_V 1.441 0.92
42_V 408_F 1.436 0.92
579_Q 582_G 1.428 0.92
67_I 222_M 1.427 0.92
409_T 419_S 1.418 0.91
76_Q 197_N 1.413 0.91
554_M 569_Q 1.399 0.91
532_L 584_L 1.391 0.90
610_F 613_S 1.39 0.90
582_G 586_R 1.375 0.90
527_V 531_T 1.372 0.90
529_G 532_L 1.372 0.90
44_E 421_L 1.372 0.90
52_T 79_L 1.367 0.89
555_E 558_R 1.36 0.89
397_A 426_F 1.359 0.89
626_A 630_L 1.358 0.89
586_R 590_D 1.354 0.89
79_L 83_D 1.354 0.89
530_D 533_S 1.353 0.89
70_T 76_Q 1.351 0.89
25_R 29_V 1.346 0.88
275_L 311_L 1.336 0.88
55_Y 198_H 1.334 0.88
477_M 494_L 1.325 0.87
468_F 528_R 1.319 0.87
557_C 568_V 1.315 0.87
453_A 483_Q 1.31 0.86
46_G 428_Y 1.31 0.86
493_L 510_A 1.308 0.86
66_V 194_V 1.305 0.86
622_D 625_R 1.299 0.86
43_V 422_L 1.298 0.86
537_I 594_L 1.297 0.86
101_K 144_D 1.295 0.86
625_R 628_R 1.295 0.86
453_A 484_F 1.294 0.85
434_L 596_I 1.279 0.85
596_I 614_L 1.277 0.84
577_L 614_L 1.277 0.84
408_F 412_L 1.274 0.84
55_Y 395_T 1.272 0.84
495_Q 520_S 1.268 0.84
232_D 436_V 1.266 0.84
503_L 515_L 1.265 0.84
186_K 189_M 1.249 0.83
457_R 487_T 1.247 0.82
108_C 168_C 1.246 0.82
42_V 409_T 1.243 0.82
75_L 197_N 1.243 0.82
583_R 590_D 1.237 0.82
250_L 437_L 1.236 0.82
611_L 619_R 1.234 0.82
30_A 33_Q 1.229 0.81
231_P 411_R 1.224 0.81
100_L 188_A 1.222 0.81
67_I 219_A 1.222 0.81
101_K 197_N 1.222 0.81
409_T 417_A 1.22 0.81
198_H 470_L 1.218 0.80
470_L 522_W 1.217 0.80
579_Q 590_D 1.216 0.80
534_L 595_V 1.214 0.80
456_L 469_M 1.21 0.80
5_F 9_G 1.21 0.80
87_V 549_L 1.208 0.80
40_P 391_S 1.207 0.80
71_G 229_Q 1.205 0.79
108_C 173_C 1.203 0.79
500_K 521_F 1.202 0.79
191_A 194_V 1.2 0.79
231_P 408_F 1.197 0.79
575_I 578_K 1.195 0.79
453_A 480_L 1.193 0.78
295_L 304_I 1.192 0.78
102_G 105_N 1.187 0.78
533_S 591_R 1.186 0.78
55_Y 68_I 1.184 0.78
386_A 394_F 1.181 0.77
241_S 371_A 1.181 0.77
46_G 552_A 1.176 0.77
73_K 105_N 1.175 0.77
463_N 533_S 1.174 0.77
493_L 506_Q 1.173 0.77
179_C 228_H 1.173 0.77
400_S 421_L 1.17 0.77
565_F 600_R 1.16 0.76
42_V 399_L 1.157 0.75
33_Q 37_K 1.155 0.75
585_I 590_D 1.154 0.75
454_A 487_T 1.15 0.75
199_H 373_T 1.149 0.75
35_I 223_I 1.145 0.74
452_L 538_D 1.143 0.74
196_V 201_F 1.141 0.74
83_D 374_P 1.136 0.74
566_D 605_P 1.133 0.73
457_R 461_E 1.132 0.73
532_L 592_G 1.132 0.73
483_Q 486_A 1.13 0.73
382_K 387_Q 1.13 0.73
585_I 592_G 1.129 0.73
424_S 520_S 1.125 0.73
46_G 422_L 1.123 0.72
540_L 573_A 1.123 0.72
100_L 148_C 1.122 0.72
136_W 140_T 1.122 0.72
474_H 478_R 1.119 0.72
55_Y 470_L 1.118 0.72
397_A 424_S 1.114 0.71
177_K 454_A 1.111 0.71
590_D 598_D 1.111 0.71
131_I 134_R 1.111 0.71
459_I 534_L 1.109 0.71
103_R 179_C 1.109 0.71
396_S 468_F 1.107 0.71
573_A 592_G 1.107 0.71
586_R 598_D 1.103 0.70
467_C 534_L 1.102 0.70
332_L 346_L 1.101 0.70
389_P 392_W 1.1 0.70
44_E 592_G 1.096 0.70
24_Q 48_G 1.079 0.68
228_H 396_S 1.071 0.67
134_R 137_S 1.069 0.67
176_Y 181_V 1.066 0.67
48_G 52_T 1.064 0.66
436_V 455_M 1.063 0.66
7_P 16_P 1.061 0.66
47_T 375_L 1.06 0.66
28_A 58_P 1.06 0.66
508_V 531_T 1.058 0.66
534_L 593_V 1.057 0.66
73_K 532_L 1.056 0.66
475_A 479_D 1.054 0.65
472_T 539_K 1.053 0.65
24_Q 51_K 1.053 0.65
394_F 408_F 1.052 0.65
435_C 595_V 1.051 0.65
394_F 562_G 1.048 0.65
21_R 584_L 1.047 0.65
454_A 458_P 1.046 0.64
521_F 571_P 1.046 0.64
102_G 426_F 1.045 0.64
460_I 514_L 1.042 0.64
102_G 197_N 1.042 0.64
202_L 230_L 1.042 0.64
608_A 612_A 1.041 0.64
26_Q 29_V 1.041 0.64
103_R 204_D 1.039 0.64
107_L 144_D 1.038 0.64
537_I 581_V 1.035 0.63
623_I 629_F 1.035 0.63
76_Q 101_K 1.034 0.63
179_C 185_R 1.032 0.63
311_L 346_L 1.031 0.63
111_R 552_A 1.031 0.63
465_G 527_V 1.031 0.63
262_L 325_S 1.028 0.62
54_A 79_L 1.027 0.62
199_H 237_Y 1.026 0.62
378_A 413_G 1.026 0.62
34_A 38_G 1.025 0.62
10_Q 14_A 1.023 0.62
69_S 201_F 1.023 0.62
78_Q 101_K 1.022 0.62
204_D 217_P 1.021 0.62
52_T 56_L 1.021 0.62
55_Y 69_S 1.021 0.62
232_D 572_D 1.02 0.62
555_E 559_L 1.019 0.61
109_L 180_F 1.018 0.61
21_R 27_M 1.018 0.61
76_Q 195_V 1.017 0.61
472_T 522_W 1.017 0.61
581_V 617_A 1.016 0.61
491_P 510_A 1.016 0.61
492_V 517_A 1.014 0.61
604_R 607_G 1.012 0.61
259_R 273_D 1.012 0.61
468_F 580_G 1.009 0.60
169_L 246_Q 1.009 0.60
164_T 167_N 1.007 0.60
492_V 516_V 1.007 0.60
550_L 569_Q 1.006 0.60
221_V 391_S 1.006 0.60
75_L 470_L 1.005 0.60
21_R 28_A 1.005 0.60
459_I 626_A 1.003 0.60
522_W 578_K 1.003 0.60
244_S 368_F 1.002 0.60
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4a15A10.91351000.315Contact Map0.528
3crvA10.84281000.371Contact Map0.458
2vl7A10.83021000.415Contact Map0.556
1gkuB10.62421000.788Contact Map0.419
3juxA10.82081000.809Contact Map0.496
4bgdA10.614899.90.825Contact Map0.488
3sqwA10.602299.90.829Contact Map0.499
3fhoA20.573999.90.83Contact Map0.428
3oiyA20.599199.90.83Contact Map0.498
4dduA10.643199.90.834Contact Map0.436
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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