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OPENSEQ.org
LOLE - Lipoprotein-releasing system transmembrane protein LolE
UniProt: P75958 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13441
Length: 414 (397)
Sequences: 10966
Seq/Len: 27.62
LOLE
Paralog alert: 0.89 [within 20: 0.41] - ratio of genomes with paralogs
Cluster includes: LOLC LOLE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
152_K 194_Q 3.706 1.00
152_K 156_D 3.381 1.00
148_I 204_A 3.349 1.00
165_W 188_H 3.333 1.00
137_A 190_A 3.09 1.00
406_D 409_R 2.86 1.00
302_I 319_F 2.787 1.00
165_W 186_R 2.784 1.00
149_I 191_G 2.768 1.00
132_F 194_Q 2.584 1.00
147_Q 190_A 2.561 1.00
306_R 312_D 2.557 1.00
92_A 229_T 2.49 1.00
150_I 189_V 2.486 1.00
233_N 236_K 2.482 1.00
90_G 229_T 2.374 1.00
206_I 211_A 2.333 1.00
331_S 384_L 2.332 1.00
155_A 192_I 2.309 1.00
150_I 154_V 2.279 1.00
167_S 186_R 2.247 1.00
400_R 404_N 2.245 1.00
148_I 206_I 2.218 1.00
323_G 395_S 2.195 1.00
90_G 240_D 2.17 1.00
228_M 237_L 2.124 1.00
83_D 86_Q 2.124 1.00
311_K 314_L 2.114 1.00
396_W 400_R 2.112 1.00
148_I 166_V 2.084 1.00
35_A 333_C 2.064 1.00
92_A 227_K 2.063 1.00
147_Q 188_H 2.049 1.00
150_I 204_A 2.046 1.00
150_I 155_A 2.024 1.00
327_G 391_S 2.016 1.00
161_K 164_D 1.986 1.00
340_V 344_Q 1.938 1.00
82_L 86_Q 1.935 1.00
90_G 237_L 1.871 1.00
238_V 242_G 1.834 1.00
316_R 400_R 1.824 1.00
298_K 322_Y 1.821 1.00
238_V 253_S 1.816 1.00
148_I 187_L 1.805 1.00
187_L 210_D 1.803 1.00
78_W 81_A 1.787 1.00
330_G 334_G 1.787 1.00
151_G 193_L 1.779 1.00
138_W 149_I 1.778 1.00
313_G 317_A 1.739 1.00
381_F 385_V 1.73 1.00
102_G 115_V 1.726 1.00
149_I 193_L 1.723 1.00
31_T 35_A 1.72 1.00
84_H 87_K 1.712 1.00
376_H 379_D 1.691 1.00
302_I 315_I 1.685 1.00
137_A 147_Q 1.671 1.00
151_G 154_V 1.654 1.00
377_W 381_F 1.654 1.00
15_R 18_R 1.632 1.00
150_I 166_V 1.631 1.00
235_N 238_V 1.627 1.00
39_A 337_I 1.625 1.00
123_E 138_W 1.617 1.00
298_K 301_D 1.617 1.00
88_V 240_D 1.588 1.00
299_S 410_V 1.585 1.00
234_A 238_V 1.583 1.00
153_G 156_D 1.58 1.00
230_D 233_N 1.579 1.00
331_S 387_A 1.567 1.00
208_L 212_Q 1.56 1.00
133_V 191_G 1.555 1.00
144_G 147_Q 1.554 1.00
160_V 189_V 1.537 1.00
303_A 410_V 1.536 1.00
97_Y 223_G 1.532 1.00
236_K 240_D 1.51 1.00
35_A 337_I 1.508 1.00
93_A 227_K 1.506 1.00
239_R 242_G 1.501 1.00
153_G 195_L 1.491 1.00
162_Q 192_I 1.484 1.00
117_G 211_A 1.47 1.00
207_P 210_D 1.465 1.00
10_G 321_W 1.463 1.00
121_Q 124_Q 1.462 1.00
149_I 190_A 1.457 1.00
88_V 244_V 1.453 1.00
334_G 338_G 1.45 1.00
146_Q 210_D 1.448 1.00
91_I 94_A 1.441 1.00
312_D 403_S 1.437 1.00
139_R 149_I 1.436 1.00
14_S 21_G 1.416 1.00
91_I 226_L 1.412 1.00
209_A 212_Q 1.401 0.99
382_Y 385_V 1.401 0.99
98_I 211_A 1.394 0.99
399_A 403_S 1.387 0.99
88_V 237_L 1.386 0.99
82_L 94_A 1.377 0.99
240_D 243_E 1.37 0.99
270_A 274_L 1.363 0.99
94_A 224_I 1.356 0.99
134_Q 152_K 1.347 0.99
20_G 297_D 1.333 0.99
139_R 190_A 1.332 0.99
284_C 394_A 1.332 0.99
13_F 322_Y 1.328 0.99
53_R 374_E 1.327 0.99
34_I 330_G 1.324 0.99
134_Q 194_Q 1.322 0.99
28_V 32_I 1.317 0.99
154_V 158_L 1.311 0.99
375_L 380_V 1.309 0.99
94_A 226_L 1.306 0.99
137_A 140_N 1.306 0.99
133_V 138_W 1.283 0.99
118_V 122_Q 1.272 0.99
77_N 81_A 1.271 0.99
80_E 84_H 1.269 0.99
135_G 161_K 1.266 0.99
43_V 341_V 1.265 0.99
39_A 341_V 1.26 0.99
235_N 239_R 1.255 0.99
253_S 256_G 1.253 0.99
162_Q 190_A 1.242 0.98
12_R 15_R 1.239 0.98
79_Q 83_D 1.223 0.98
385_V 389_L 1.221 0.98
80_E 83_D 1.221 0.98
400_R 403_S 1.219 0.98
53_R 57_N 1.218 0.98
160_V 164_D 1.214 0.98
49_N 376_H 1.213 0.98
340_V 343_L 1.212 0.98
336_I 340_V 1.207 0.98
232_F 237_L 1.204 0.98
399_A 402_A 1.2 0.98
397_Y 400_R 1.196 0.98
237_L 240_D 1.196 0.98
85_V 94_A 1.195 0.98
66_G 238_V 1.192 0.98
273_Y 277_V 1.189 0.98
398_P 402_A 1.183 0.98
42_I 338_G 1.18 0.98
378_L 382_Y 1.178 0.98
81_A 84_H 1.177 0.98
333_C 336_I 1.175 0.98
327_G 331_S 1.175 0.98
104_V 113_I 1.17 0.97
49_N 53_R 1.168 0.97
238_V 251_I 1.165 0.97
135_G 162_Q 1.162 0.97
338_G 342_S 1.157 0.97
314_L 317_A 1.143 0.97
239_R 243_E 1.141 0.97
305_L 318_I 1.138 0.97
193_L 205_M 1.135 0.97
327_G 387_A 1.132 0.97
21_G 326_A 1.131 0.97
19_R 28_V 1.126 0.97
115_V 206_I 1.126 0.97
31_T 330_G 1.125 0.97
118_V 205_M 1.121 0.97
54_E 58_R 1.111 0.96
11_L 15_R 1.109 0.96
332_L 336_I 1.108 0.96
303_A 307_T 1.101 0.96
168_I 187_L 1.082 0.96
374_E 377_W 1.08 0.95
229_T 233_N 1.075 0.95
84_H 244_V 1.073 0.95
38_V 334_G 1.072 0.95
115_V 204_A 1.071 0.95
331_S 391_S 1.07 0.95
291_L 323_G 1.068 0.95
228_M 234_A 1.066 0.95
113_I 204_A 1.062 0.95
97_Y 225_A 1.061 0.95
95_A 118_V 1.06 0.95
335_V 380_V 1.058 0.95
324_L 392_L 1.058 0.95
39_A 338_G 1.057 0.95
149_I 205_M 1.051 0.94
85_V 241_A 1.05 0.94
85_V 226_L 1.048 0.94
339_V 375_L 1.048 0.94
242_G 251_I 1.044 0.94
136_D 191_G 1.044 0.94
151_G 202_S 1.039 0.94
147_Q 207_P 1.037 0.94
299_S 413_G 1.033 0.94
312_D 404_N 1.033 0.94
148_I 189_V 1.024 0.93
91_I 229_T 1.019 0.93
98_I 212_Q 1.018 0.93
299_S 303_A 1.017 0.93
146_Q 185_V 1.016 0.93
105_E 167_S 1.015 0.93
96_P 119_N 1.013 0.93
344_Q 348_I 1.012 0.93
100_F 215_L 1.01 0.93
46_S 50_G 1.008 0.93
394_A 398_P 1.003 0.93
294_A 298_K 1.002 0.92
407_P 410_V 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ftjA10.483199.40.777Contact Map0.846
3is6A20.497698.90.823Contact Map0.734
3o27A20.15949.70.961Contact Map0.552
2kogA10.0997.30.963Contact Map0.329
1yfbA20.142560.964Contact Map0.622
2l66A20.1285.10.965Contact Map0.627
1wi9A10.17154.30.967Contact Map0.115
3hd7A20.0992.50.97Contact Map0.602
3tuiA40.24642.50.97Contact Map0.4
3d31C20.40822.10.972Contact Map0.267
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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