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OPENSEQ.org

YCBL - Uncharacterized protein YcbL
UniProt: P75849 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13704
Length: 215 (210)
Sequences: 8144
Seq/Len: 38.78

YCBL
Paralog alert: 0.71 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: GLO2 YCBL
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
129_C 138_V 5.252 1.00
25_L 50_M 4.074 1.00
54_L 65_A 3.574 1.00
184_D 202_R 3.222 1.00
113_E 178_K 3.126 1.00
126_V 137_V 3.016 1.00
116_T 123_T 2.934 1.00
53_L 139_F 2.854 1.00
116_T 125_Q 2.839 1.00
51_Q 77_F 2.825 1.00
118_S 123_T 2.768 1.00
125_Q 142_D 2.738 1.00
81_K 112_N 2.634 1.00
167_D 170_Q 2.284 1.00
124_L 141_D 2.221 1.00
75_P 109_R 2.215 1.00
25_L 48_T 2.139 1.00
27_A 51_Q 2.121 1.00
29_V 148_I 2.106 1.00
126_V 139_F 2.047 1.00
42_V 49_L 2.04 1.00
184_D 199_G 1.992 1.00
77_F 111_L 1.979 1.00
39_K 71_H 1.978 1.00
69_A 108_D 1.959 1.00
173_S 177_D 1.934 1.00
77_F 109_R 1.911 1.00
16_S 189_I 1.898 1.00
51_Q 75_P 1.761 1.00
138_V 147_L 1.695 1.00
41_E 44_D 1.693 1.00
20_C 23_T 1.69 1.00
80_E 128_H 1.684 1.00
40_Q 44_D 1.677 1.00
26_A 47_L 1.677 1.00
83_D 135_G 1.644 1.00
41_E 45_S 1.613 1.00
146_L 189_I 1.597 1.00
109_R 115_D 1.579 1.00
112_N 115_D 1.555 1.00
141_D 144_A 1.555 1.00
19_W 47_L 1.545 1.00
39_K 72_Y 1.522 1.00
29_V 55_T 1.516 1.00
65_A 76_V 1.509 1.00
49_L 74_V 1.507 1.00
26_A 49_L 1.487 1.00
36_E 40_Q 1.468 1.00
84_E 88_Q 1.454 1.00
145_K 186_V 1.447 1.00
113_E 128_H 1.438 1.00
31_P 52_I 1.412 1.00
127_L 178_K 1.411 1.00
187_I 195_L 1.387 0.99
22_Q 121_N 1.38 0.99
19_W 26_A 1.375 0.99
140_F 186_V 1.371 0.99
80_E 137_V 1.358 0.99
138_V 152_V 1.356 0.99
39_K 43_D 1.352 0.99
170_Q 173_S 1.35 0.99
27_A 53_L 1.349 0.99
140_F 147_L 1.338 0.99
131_G 174_S 1.329 0.99
43_D 71_H 1.296 0.99
129_C 174_S 1.293 0.99
40_Q 43_D 1.293 0.99
145_K 185_D 1.29 0.99
67_E 71_H 1.263 0.99
125_Q 140_F 1.258 0.99
180_L 208_L 1.23 0.98
69_A 76_V 1.23 0.98
28_L 49_L 1.23 0.98
147_L 188_F 1.222 0.98
127_L 140_F 1.22 0.98
200_Y 204_H 1.205 0.98
35_A 64_A 1.201 0.98
118_S 121_N 1.201 0.98
81_K 110_W 1.2 0.98
66_A 70_Q 1.189 0.98
28_L 31_P 1.165 0.97
111_L 137_V 1.16 0.97
122_V 141_D 1.159 0.97
66_A 69_A 1.151 0.97
152_V 179_L 1.15 0.97
82_E 135_G 1.135 0.97
169_N 173_S 1.123 0.97
147_L 182_L 1.119 0.96
138_V 179_L 1.119 0.96
27_A 119_I 1.115 0.96
179_L 198_L 1.107 0.96
196_S 201_E 1.095 0.96
188_F 196_S 1.094 0.96
183_G 186_V 1.089 0.96
130_P 174_S 1.08 0.95
27_A 124_L 1.058 0.95
55_T 150_G 1.05 0.94
199_G 203_L 1.033 0.94
49_L 72_Y 1.031 0.94
177_D 181_P 1.028 0.94
168_H 171_L 1.02 0.93
15_C 38_I 1.017 0.93
133_T 136_H 1.012 0.93
134_P 170_Q 1.005 0.93
26_A 50_M 1.003 0.93
188_F 198_L 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xf4A10.96741000.238Contact Map0.833
3r2uA40.93491000.249Contact Map0.82
3tp9A20.93021000.259Contact Map0.862
4efzA20.97671000.26Contact Map0.813
2zwrA20.95351000.265Contact Map0.811
1qh5A20.87911000.279Contact Map0.84
1xm8A20.88841000.286Contact Map0.894
2p18A10.88371000.287Contact Map0.799
2gcuA40.90231000.306Contact Map0.866
2qedA10.86511000.316Contact Map0.875

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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