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RLMC - 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC
UniProt: P75817 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13427
Length: 375 (374)
Sequences: 2902
Seq/Len: 7.76
RLMC
Paralog alert: 0.54 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RLMC RLMD TRMA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
343_I 372_L 4.08 1.00
352_E 373_V 3.98 1.00
23_E 26_S 3.515 1.00
29_T 33_K 3.154 1.00
257_Q 284_Q 3.053 1.00
242_C 260_G 2.869 1.00
3_C 11_C 2.78 1.00
11_C 14_C 2.732 1.00
304_V 321_L 2.719 1.00
3_C 14_C 2.716 1.00
24_Q 362_H 2.521 1.00
251_C 305_L 2.51 1.00
306_V 313_I 2.464 1.00
3_C 87_C 2.445 1.00
197_R 200_D 2.412 1.00
83_D 102_K 2.383 1.00
197_R 202_P 2.369 1.00
21_I 25_L 2.346 1.00
224_T 227_D 2.298 1.00
351_I 370_T 2.289 1.00
14_C 87_C 2.286 1.00
11_C 87_C 2.263 1.00
288_L 293_F 2.254 1.00
339_M 370_T 2.209 1.00
321_L 329_I 2.177 1.00
142_L 170_V 2.172 1.00
228_W 353_R 2.166 1.00
206_R 270_C 2.144 1.00
91_P 129_E 2.142 1.00
262_E 268_I 2.139 1.00
195_A 202_P 2.114 1.00
225_A 332_S 2.109 1.00
242_C 268_I 2.038 1.00
54_G 92_A 2.019 1.00
32_L 366_Y 1.966 1.00
328_F 373_V 1.952 1.00
339_M 368_V 1.935 1.00
236_H 257_Q 1.924 1.00
30_A 34_N 1.907 1.00
238_W 301_P 1.881 1.00
302_E 327_R 1.849 1.00
221_L 357_F 1.834 1.00
350_R 373_V 1.827 1.00
204_W 273_Q 1.806 1.00
47_P 50_G 1.776 1.00
30_A 33_K 1.774 1.00
237_M 255_D 1.761 1.00
26_S 29_T 1.752 1.00
325_A 374_K 1.741 1.00
260_G 271_A 1.735 1.00
318_C 345_E 1.732 1.00
36_L 343_I 1.704 1.00
92_A 96_P 1.699 1.00
223_A 227_D 1.692 1.00
313_I 318_C 1.672 1.00
32_L 356_L 1.671 1.00
339_M 343_I 1.667 1.00
335_N 338_T 1.661 1.00
248_G 258_L 1.654 1.00
193_A 204_W 1.651 1.00
11_C 17_I 1.628 1.00
289_D 292_Q 1.622 1.00
273_Q 276_A 1.617 1.00
158_L 165_L 1.605 1.00
226_R 254_P 1.59 1.00
229_V 303_L 1.587 1.00
280_L 283_L 1.585 1.00
20_P 23_E 1.579 1.00
271_A 285_F 1.573 1.00
304_V 326_P 1.548 1.00
2_Q 88_P 1.53 1.00
265_S 269_A 1.53 1.00
202_P 277_E 1.512 1.00
315_K 319_D 1.502 0.99
326_P 349_F 1.501 0.99
260_G 285_F 1.473 0.99
228_W 371_L 1.458 0.99
318_C 346_L 1.455 0.99
343_I 351_I 1.441 0.99
29_T 47_P 1.42 0.99
275_A 285_F 1.42 0.99
352_E 371_L 1.419 0.99
5_L 84_L 1.417 0.99
59_A 90_Y 1.415 0.99
343_I 370_T 1.402 0.99
240_L 317_L 1.369 0.99
269_A 272_K 1.364 0.99
26_S 30_A 1.359 0.99
137_M 167_V 1.358 0.99
327_R 373_V 1.346 0.99
167_V 192_Q 1.346 0.99
46_A 353_R 1.346 0.99
76_H 80_T 1.34 0.99
69_K 106_A 1.335 0.99
329_I 346_L 1.333 0.98
187_Y 192_Q 1.327 0.98
225_A 330_I 1.326 0.98
6_Y 18_M 1.322 0.98
36_L 354_V 1.321 0.98
57_N 215_P 1.307 0.98
235_K 302_E 1.304 0.98
201_V 249_L 1.303 0.98
329_I 349_F 1.302 0.98
166_K 191_Q 1.301 0.98
219_S 223_A 1.298 0.98
249_L 280_L 1.284 0.98
14_C 17_I 1.283 0.98
16_W 27_A 1.281 0.98
234_V 256_M 1.28 0.98
249_L 275_A 1.276 0.98
218_A 246_G 1.271 0.98
252_A 280_L 1.268 0.98
229_V 330_I 1.262 0.98
107_R 157_W 1.256 0.98
222_Y 247_F 1.251 0.97
2_Q 53_Q 1.245 0.97
241_F 291_T 1.242 0.97
224_T 228_W 1.241 0.97
143_R 174_P 1.241 0.97
126_L 139_R 1.234 0.97
249_L 283_L 1.231 0.97
157_W 161_Q 1.23 0.97
15_Q 364_A 1.224 0.97
94_F 127_L 1.224 0.97
225_A 305_L 1.219 0.97
3_C 17_I 1.216 0.97
93_S 129_E 1.214 0.97
213_T 339_M 1.21 0.97
201_V 253_T 1.208 0.97
315_K 345_E 1.2 0.97
224_T 355_Q 1.195 0.96
45_C 353_R 1.192 0.96
33_K 37_A 1.185 0.96
201_V 252_A 1.177 0.96
213_T 359_M 1.172 0.96
159_H 189_T 1.166 0.96
353_R 371_L 1.164 0.96
242_C 271_A 1.161 0.96
70_P 105_I 1.156 0.95
333_S 338_T 1.155 0.95
260_G 283_L 1.15 0.95
255_D 282_R 1.142 0.95
93_S 96_P 1.137 0.95
259_T 286_Q 1.133 0.95
19_Q 23_E 1.132 0.95
105_I 122_L 1.126 0.95
274_S 278_L 1.112 0.94
370_T 373_V 1.108 0.94
90_Y 94_F 1.107 0.94
103_P 161_Q 1.106 0.94
135_G 191_Q 1.105 0.94
4_A 86_D 1.101 0.94
13_S 87_C 1.101 0.94
242_C 285_F 1.099 0.94
351_I 372_L 1.093 0.93
130_S 133_D 1.092 0.93
169_T 187_Y 1.091 0.93
303_L 330_I 1.09 0.93
6_Y 15_Q 1.08 0.93
195_A 204_W 1.075 0.93
59_A 74_M 1.063 0.92
118_K 176_H 1.054 0.92
209_S 267_A 1.054 0.92
350_R 375_Q 1.052 0.91
268_I 287_A 1.05 0.91
232_L 235_K 1.048 0.91
221_L 359_M 1.047 0.91
62_V 75_L 1.045 0.91
229_V 328_F 1.038 0.91
268_I 272_K 1.038 0.91
237_M 303_L 1.024 0.90
231_Q 303_L 1.021 0.90
97_V 136_M 1.02 0.90
100_A 161_Q 1.019 0.90
224_T 369_L 1.017 0.90
62_V 81_P 1.014 0.89
105_I 112_P 1.011 0.89
63_V 125_I 1.009 0.89
103_P 106_A 1.004 0.89
319_D 345_E 1.003 0.89
199_N 219_S 1.003 0.89
51_P 216_A 1 0.89
265_S 287_A 1 0.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2jjqA10.91731000.229Contact Map0.734
1uwvA10.921000.269Contact Map0.705
3bt7A20.91731000.315Contact Map0.732
3vseA40.881000.63Contact Map0.426
4dmgA20.88531000.649Contact Map0.49
2b78A10.88271000.672Contact Map0.44
1wxxA40.8641000.673Contact Map0.602
3c0kA20.87731000.679Contact Map0.585
3a27A10.67731000.715Contact Map0.601
2as0A20.881000.717Contact Map0.531
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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