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OPENSEQ.org
DIAA - DnaA initiator-associating protein DiaA
UniProt: P66817 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12780
Length: 196 (193)
Sequences: 976
Seq/Len: 5.06
DIAA
Paralog alert: 0.57 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: DIAA GMHA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
47_C 113_L 4.371 1.00
107_G 137_M 3.712 1.00
129_V 150_L 3.303 1.00
141_A 156_P 3.023 1.00
37_S 112_V 2.962 1.00
127_K 130_E 2.486 1.00
59_F 179_V 2.398 1.00
30_A 140_V 2.377 1.00
129_V 139_I 2.282 1.00
37_S 42_N 2.193 1.00
46_C 59_F 2.057 1.00
12_S 16_Q 2.052 1.00
45_L 103_V 1.974 1.00
70_E 93_R 1.956 1.00
121_N 149_E 1.914 1.00
31_A 185_L 1.797 1.00
133_V 158_D 1.716 1.00
46_C 114_L 1.711 1.00
47_C 125_I 1.673 0.99
64_I 85_V 1.666 0.99
73_S 105_A 1.651 0.99
42_N 110_G 1.629 0.99
63_M 186_I 1.584 0.99
86_L 98_V 1.571 0.99
117_S 150_L 1.563 0.99
30_A 159_V 1.557 0.99
46_C 179_V 1.546 0.99
142_L 178_T 1.503 0.99
57_Q 83_N 1.492 0.98
85_V 89_I 1.464 0.98
144_G 171_I 1.413 0.98
170_R 173_E 1.41 0.98
115_A 129_V 1.404 0.97
33_T 159_V 1.369 0.97
130_E 153_L 1.367 0.97
81_T 84_V 1.33 0.96
161_I 178_T 1.328 0.96
38_L 44_I 1.309 0.96
65_N 89_I 1.292 0.95
55_N 62_S 1.273 0.95
118_T 168_S 1.272 0.95
47_C 115_A 1.27 0.95
27_I 178_T 1.264 0.95
90_A 95_H 1.263 0.95
97_E 127_K 1.257 0.94
121_N 148_G 1.244 0.94
163_I 174_M 1.243 0.94
45_L 77_I 1.227 0.93
13_I 16_Q 1.223 0.93
10_T 14_Q 1.212 0.93
115_A 125_I 1.21 0.93
78_A 81_T 1.205 0.93
73_S 104_R 1.204 0.93
131_A 134_T 1.203 0.92
13_I 17_I 1.195 0.92
61_A 65_N 1.193 0.92
42_N 108_H 1.188 0.92
34_L 44_I 1.186 0.92
68_E 167_R 1.183 0.92
118_T 172_Q 1.179 0.91
143_T 162_R 1.176 0.91
58_H 62_S 1.173 0.91
96_D 123_R 1.166 0.91
146_D 162_R 1.163 0.91
115_A 139_I 1.162 0.91
95_H 98_V 1.161 0.91
143_T 160_E 1.161 0.91
104_R 131_A 1.158 0.90
33_T 138_T 1.158 0.90
47_C 128_A 1.155 0.90
57_Q 81_T 1.154 0.90
131_A 135_R 1.138 0.89
149_E 152_G 1.134 0.89
91_N 119_R 1.133 0.89
62_S 172_Q 1.117 0.88
79_L 102_Q 1.115 0.88
55_N 118_T 1.096 0.87
57_Q 80_N 1.09 0.87
44_I 114_L 1.089 0.87
94_L 97_E 1.086 0.86
49_N 124_D 1.085 0.86
65_N 88_A 1.082 0.86
141_A 160_E 1.082 0.86
58_H 91_N 1.072 0.85
77_I 106_L 1.07 0.85
130_E 134_T 1.065 0.85
62_S 118_T 1.062 0.85
34_L 186_I 1.047 0.83
36_Q 40_N 1.045 0.83
5_I 28_S 1.044 0.83
151_A 162_R 1.044 0.83
34_L 182_L 1.04 0.83
28_S 32_M 1.038 0.83
61_A 88_A 1.036 0.83
113_L 128_A 1.033 0.82
169_A 183_C 1.029 0.82
109_A 136_D 1.021 0.81
12_S 174_M 1.013 0.81
113_L 137_M 1.007 0.80
91_N 122_S 1.002 0.80
34_L 112_V 1 0.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i2wA40.95921000.469Contact Map0.734
2yvaA211000.487Contact Map0.767
1tk9A40.9491000.502Contact Map0.858
1x92A20.99491000.505Contact Map0.782
2xblA40.97451000.507Contact Map0.812
3trjA411000.507Contact Map0.837
3cvjA40.954199.90.653Contact Map0.758
4bb9A10.989899.90.655Contact Map0.477
3w0lB20.994999.90.665Contact Map0.545
1nriA10.984799.90.67Contact Map0.646
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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