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LSRG - Autoinducer 2-degrading protein LsrG
UniProt: P64461 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13811
Length: 96 (94)
Sequences: 1257
Seq/Len: 13.37

LSRG
Paralog alert: 0.47 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: LSRG YGIN
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_E 63_A 2.843 1.00
58_D 61_A 2.652 1.00
14_K 17_E 2.456 1.00
15_V 48_S 2.114 1.00
4_T 62_V 2.087 1.00
34_G 61_A 2.068 1.00
10_V 18_F 1.863 1.00
36_L 57_K 1.853 1.00
9_N 84_G 1.777 1.00
15_V 42_Q 1.728 1.00
69_P 73_T 1.666 1.00
9_N 46_V 1.545 1.00
73_T 77_K 1.544 1.00
19_I 23_R 1.541 1.00
37_R 55_A 1.456 1.00
9_N 49_R 1.434 1.00
30_V 35_N 1.414 1.00
14_K 81_L 1.409 1.00
25_N 38_F 1.406 0.99
46_V 49_R 1.386 0.99
19_I 50_F 1.329 0.99
11_H 83_T 1.301 0.99
29_S 66_K 1.296 0.99
42_Q 50_F 1.292 0.99
63_A 67_T 1.29 0.99
74_C 78_L 1.283 0.99
60_D 63_A 1.279 0.99
56_Y 62_V 1.279 0.99
67_T 72_K 1.272 0.99
7_E 49_R 1.265 0.99
19_I 42_Q 1.263 0.99
16_D 20_E 1.258 0.99
84_G 87_K 1.246 0.98
17_E 20_E 1.234 0.98
60_D 64_F 1.224 0.98
33_E 57_K 1.223 0.98
29_S 71_Y 1.208 0.98
29_S 70_H 1.19 0.98
10_V 22_F 1.189 0.98
71_Y 75_V 1.172 0.98
62_V 66_K 1.156 0.97
25_N 74_C 1.152 0.97
15_V 50_F 1.147 0.97
59_E 90_L 1.137 0.97
24_Q 73_T 1.115 0.96
28_G 31_Q 1.096 0.96
18_F 22_F 1.092 0.96
21_V 24_Q 1.086 0.96
56_Y 66_K 1.078 0.95
28_G 70_H 1.076 0.95
42_Q 46_V 1.073 0.95
17_E 81_L 1.072 0.95
15_V 19_I 1.066 0.95
10_V 50_F 1.022 0.93
33_E 61_A 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2omoA8199.90.175Contact Map0.717
4dpoA20.989699.90.19Contact Map0.684
2gffA2199.90.201Contact Map0.671
3mcsA20.989699.90.203Contact Map0.679
1tuvA10.989699.90.204Contact Map0.721
4hl9A9199.90.208Contact Map0.844
3bm7A10.989699.90.209Contact Map0.533
3e8oA2199.90.211Contact Map0.56
3gz7A20.989699.90.214Contact Map0.726
2pd1A40.979299.90.215Contact Map0.672

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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