| UniProt: | P60664 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10448 | ||
| Length: | 258 (251) | ||
| Sequences: | 3041 | ||
| Seq/Len: | 12.12 |
| HIS6
Paralog alert: 0.96 [within 20: 0.54] - ratio of genomes with paralogs Cluster includes: HIS4 HIS6 |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 109_D | 115_R | 3.4 | 1.00 | |
| 89_A | 116_L | 3.293 | 1.00 | |
| 167_Q | 202_V | 3.274 | 1.00 | |
| 217_L | 251_Q | 2.815 | 1.00 | |
| 114_T | 169_R | 2.783 | 1.00 | |
| 37_K | 41_E | 2.71 | 1.00 | |
| 165_E | 169_R | 2.71 | 1.00 | |
| 129_I | 163_V | 2.456 | 1.00 | |
| 145_Y | 153_R | 2.452 | 1.00 | |
| 214_E | 217_L | 2.384 | 1.00 | |
| 141_H | 154_V | 2.291 | 1.00 | |
| 127_V | 166_V | 2.267 | 1.00 | |
| 83_I | 92_I | 2.245 | 1.00 | |
| 85_S | 88_D | 2.197 | 1.00 | |
| 37_K | 72_V | 2.177 | 1.00 | |
| 185_R | 238_I | 2.067 | 1.00 | |
| 90_A | 94_S | 2.023 | 1.00 | |
| 212_T | 215_H | 2.013 | 1.00 | |
| 38_R | 42_E | 1.952 | 1.00 | |
| 240_N | 243_E | 1.913 | 1.00 | |
| 111_T | 115_R | 1.883 | 1.00 | |
| 108_A | 145_Y | 1.869 | 1.00 | |
| 141_H | 156_Q | 1.866 | 1.00 | |
| 116_L | 125_I | 1.864 | 1.00 | |
| 210_A | 219_A | 1.859 | 1.00 | |
| 31_D | 34_P | 1.844 | 1.00 | |
| 198_E | 224_D | 1.824 | 1.00 | |
| 31_D | 68_R | 1.815 | 1.00 | |
| 167_Q | 201_H | 1.793 | 1.00 | |
| 165_E | 168_K | 1.792 | 1.00 | |
| 63_K | 91_K | 1.789 | 1.00 | |
| 233_V | 239_I | 1.781 | 1.00 | |
| 40_A | 74_D | 1.779 | 1.00 | |
| 89_A | 125_I | 1.753 | 1.00 | |
| 214_E | 218_E | 1.728 | 1.00 | |
| 164_Q | 199_V | 1.676 | 1.00 | |
| 21_V | 184_V | 1.675 | 1.00 | |
| 16_Q | 28_I | 1.674 | 1.00 | |
| 141_H | 158_E | 1.668 | 1.00 | |
| 47_L | 75_I | 1.663 | 1.00 | |
| 194_K | 198_E | 1.643 | 1.00 | |
| 55_S | 104_S | 1.639 | 1.00 | |
| 99_K | 126_V | 1.631 | 1.00 | |
| 62_D | 65_W | 1.62 | 1.00 | |
| 64_S | 67_S | 1.617 | 1.00 | |
| 114_T | 118_D | 1.597 | 1.00 | |
| 128_G | 175_V | 1.591 | 1.00 | |
| 242_G | 246_A | 1.577 | 1.00 | |
| 68_R | 71_E | 1.57 | 1.00 | |
| 107_L | 144_Q | 1.56 | 1.00 | |
| 230_A | 233_V | 1.558 | 1.00 | |
| 90_A | 119_R | 1.554 | 1.00 | |
| 86_L | 116_L | 1.547 | 1.00 | |
| 247_Y | 251_Q | 1.538 | 1.00 | |
| 217_L | 247_Y | 1.531 | 1.00 | |
| 176_L | 192_Q | 1.505 | 1.00 | |
| 56_S | 148_D | 1.495 | 1.00 | |
| 135_A | 191_E | 1.474 | 1.00 | |
| 158_E | 161_D | 1.472 | 1.00 | |
| 157_W | 165_E | 1.466 | 1.00 | |
| 213_M | 239_I | 1.463 | 1.00 | |
| 239_I | 244_L | 1.444 | 1.00 | |
| 144_Q | 153_R | 1.43 | 1.00 | |
| 176_L | 196_V | 1.419 | 1.00 | |
| 108_A | 144_Q | 1.414 | 1.00 | |
| 46_E | 99_K | 1.391 | 0.99 | |
| 111_T | 114_T | 1.389 | 0.99 | |
| 246_A | 250_T | 1.384 | 0.99 | |
| 14_D | 53_T | 1.377 | 0.99 | |
| 104_S | 108_A | 1.376 | 0.99 | |
| 93_L | 124_C | 1.375 | 0.99 | |
| 159_T | 196_V | 1.372 | 0.99 | |
| 42_E | 242_G | 1.363 | 0.99 | |
| 164_Q | 168_K | 1.35 | 0.99 | |
| 117_A | 122_V | 1.347 | 0.99 | |
| 217_L | 221_R | 1.335 | 0.99 | |
| 220_F | 228_A | 1.33 | 0.99 | |
| 216_F | 233_V | 1.323 | 0.99 | |
| 143_N | 154_V | 1.306 | 0.99 | |
| 128_G | 177_N | 1.292 | 0.99 | |
| 7_I | 46_E | 1.29 | 0.99 | |
| 108_A | 153_R | 1.286 | 0.99 | |
| 89_A | 100_I | 1.285 | 0.99 | |
| 230_A | 234_F | 1.278 | 0.99 | |
| 5_R | 46_E | 1.277 | 0.99 | |
| 38_R | 41_E | 1.272 | 0.99 | |
| 195_K | 199_V | 1.269 | 0.99 | |
| 86_L | 115_R | 1.267 | 0.99 | |
| 105_P | 112_L | 1.264 | 0.99 | |
| 8_P | 44_A | 1.252 | 0.99 | |
| 60_V | 91_K | 1.247 | 0.99 | |
| 219_A | 225_V | 1.245 | 0.98 | |
| 195_K | 198_E | 1.213 | 0.98 | |
| 64_S | 68_R | 1.209 | 0.98 | |
| 102_I | 105_P | 1.195 | 0.98 | |
| 172_G | 203_P | 1.186 | 0.98 | |
| 23_F | 56_S | 1.174 | 0.98 | |
| 131_T | 176_L | 1.164 | 0.97 | |
| 163_V | 196_V | 1.155 | 0.97 | |
| 22_Q | 184_V | 1.151 | 0.97 | |
| 70_A | 77_F | 1.149 | 0.97 | |
| 67_S | 71_E | 1.142 | 0.97 | |
| 161_D | 165_E | 1.121 | 0.97 | |
| 49_F | 69_V | 1.119 | 0.96 | |
| 190_L | 218_E | 1.118 | 0.96 | |
| 178_M | 189_D | 1.117 | 0.96 | |
| 197_R | 204_L | 1.113 | 0.96 | |
| 246_A | 257_I | 1.102 | 0.96 | |
| 66_V | 79_V | 1.101 | 0.96 | |
| 196_V | 204_L | 1.099 | 0.96 | |
| 107_L | 157_W | 1.095 | 0.96 | |
| 13_R | 26_H | 1.09 | 0.96 | |
| 159_T | 163_V | 1.089 | 0.96 | |
| 4_K | 220_F | 1.088 | 0.96 | |
| 87_E | 90_A | 1.085 | 0.96 | |
| 33_V | 65_W | 1.081 | 0.95 | |
| 113_I | 166_V | 1.065 | 0.95 | |
| 193_L | 197_R | 1.054 | 0.95 | |
| 3_A | 254_E | 1.049 | 0.94 | |
| 114_T | 165_E | 1.037 | 0.94 | |
| 213_M | 247_Y | 1.033 | 0.94 | |
| 197_R | 224_D | 1.027 | 0.94 | |
| 42_E | 240_N | 1.019 | 0.93 | |
| 194_K | 222_D | 1.019 | 0.93 | |
| 175_V | 229_L | 1.015 | 0.93 | |
| 216_F | 244_L | 1.006 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1jvnA | 2 | 0.9767 | 100 | 0.242 | Contact Map | 0.765 |
| 2agkA | 1 | 0.9031 | 100 | 0.276 | Contact Map | 0.603 |
| 1qo2A | 2 | 0.9031 | 100 | 0.454 | Contact Map | 0.672 |
| 1thfD | 1 | 0.9729 | 100 | 0.464 | Contact Map | 0.796 |
| 4evzA | 2 | 0.969 | 100 | 0.47 | Contact Map | 0.727 |
| 2y88A | 1 | 0.9302 | 100 | 0.493 | Contact Map | 0.7 |
| 1ka9F | 1 | 0.9729 | 100 | 0.495 | Contact Map | 0.718 |
| 1vzwA | 1 | 0.9302 | 100 | 0.498 | Contact Map | 0.682 |
| 1h5yA | 2 | 0.969 | 100 | 0.499 | Contact Map | 0.719 |
| 4gj1A | 1 | 0.9264 | 100 | 0.503 | Contact Map | 0.701 |
Sequence Conservation (Image Generated using WebLogo v3)