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OPENSEQ.org
YRBG - Inner membrane protein YrbG
UniProt: P45394 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12802
Length: 325 (317)
Sequences: 2200
Seq/Len: 6.94
YRBG
Paralog alert: 0.20 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: CHAA YRBG
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
79_I 218_I 3.092 1.00
79_I 83_L 2.886 1.00
82_L 282_V 2.799 1.00
43_T 46_S 2.703 1.00
129_G 260_A 2.522 1.00
121_D 128_D 2.511 1.00
118_V 128_D 2.325 1.00
49_T 224_E 2.075 1.00
202_N 208_E 1.938 1.00
89_A 302_G 1.918 1.00
7_L 196_N 1.914 1.00
108_M 283_S 1.866 1.00
4_A 199_V 1.812 1.00
133_L 137_V 1.796 1.00
137_V 141_L 1.781 1.00
77_N 251_N 1.756 1.00
176_F 180_G 1.675 1.00
76_S 80_N 1.651 1.00
17_Y 20_D 1.624 1.00
18_S 189_A 1.611 1.00
90_L 306_T 1.605 1.00
196_N 199_V 1.593 1.00
37_P 236_E 1.593 1.00
141_L 145_K 1.572 1.00
136_A 254_I 1.567 1.00
173_P 177_L 1.565 1.00
90_L 303_V 1.559 1.00
292_R 301_V 1.541 0.99
8_L 196_N 1.522 0.99
55_I 190_T 1.519 0.99
221_S 225_L 1.513 0.99
45_V 239_I 1.512 0.99
217_A 221_S 1.511 0.99
17_Y 21_R 1.51 0.99
201_A 211_M 1.508 0.99
80_N 248_N 1.506 0.99
115_A 252_I 1.489 0.99
197_A 216_I 1.465 0.99
307_G 311_V 1.458 0.99
235_G 240_A 1.453 0.99
19_A 48_G 1.422 0.99
50_S 247_A 1.421 0.99
58_L 262_I 1.42 0.99
115_A 119_L 1.416 0.99
191_R 195_D 1.414 0.99
251_N 255_V 1.408 0.99
35_I 39_I 1.399 0.99
247_A 250_F 1.398 0.99
206_I 210_T 1.392 0.99
285_I 308_G 1.383 0.99
21_R 178_W 1.378 0.99
57_S 72_T 1.362 0.98
48_G 240_A 1.362 0.98
86_G 302_G 1.36 0.98
80_N 247_A 1.359 0.98
67_D 268_D 1.342 0.98
83_L 218_I 1.34 0.98
113_V 117_S 1.339 0.98
25_A 182_A 1.334 0.98
54_V 73_A 1.331 0.98
298_G 301_V 1.323 0.98
177_L 181_I 1.318 0.98
54_V 255_V 1.318 0.98
156_D 162_Q 1.314 0.98
42_M 45_V 1.308 0.98
133_L 261_L 1.303 0.98
65_Q 208_E 1.289 0.97
67_D 71_G 1.282 0.97
275_D 312_W 1.275 0.97
11_G 189_A 1.273 0.97
199_V 202_N 1.264 0.97
25_A 179_L 1.263 0.97
68_L 309_F 1.255 0.97
220_T 223_P 1.251 0.97
92_R 235_G 1.248 0.97
193_V 309_F 1.247 0.97
130_I 261_L 1.241 0.97
153_Q 156_D 1.237 0.97
76_S 221_S 1.236 0.97
272_Y 277_S 1.23 0.96
55_I 187_P 1.221 0.96
183_L 187_P 1.219 0.96
200_L 204_F 1.214 0.96
82_L 305_L 1.212 0.96
53_E 220_T 1.206 0.96
26_A 40_I 1.201 0.96
57_S 61_S 1.194 0.96
93_P 299_R 1.193 0.96
196_N 200_L 1.19 0.95
11_G 14_L 1.185 0.95
53_E 223_P 1.18 0.95
116_G 280_L 1.177 0.95
47_I 250_F 1.174 0.95
293_R 301_V 1.169 0.95
80_N 223_P 1.168 0.95
10_V 13_L 1.166 0.95
15_V 23_V 1.165 0.95
269_P 272_Y 1.162 0.95
256_L 259_P 1.161 0.95
81_I 247_A 1.155 0.94
47_I 51_L 1.154 0.94
135_L 139_W 1.154 0.94
77_N 247_A 1.152 0.94
129_G 257_G 1.139 0.94
271_A 274_R 1.138 0.94
49_T 223_P 1.138 0.94
87_L 91_V 1.137 0.94
76_S 248_N 1.137 0.94
54_V 58_L 1.133 0.94
51_L 255_V 1.13 0.93
219_G 223_P 1.124 0.93
88_A 228_A 1.122 0.93
47_I 136_A 1.121 0.93
94_F 177_L 1.119 0.93
181_I 185_I 1.116 0.93
183_L 213_L 1.105 0.92
130_I 134_F 1.102 0.92
111_V 253_V 1.097 0.92
265_G 269_P 1.097 0.92
227_T 231_G 1.093 0.92
192_M 195_D 1.088 0.92
228_A 248_N 1.086 0.92
300_G 303_V 1.086 0.92
118_V 131_F 1.084 0.92
19_A 27_S 1.083 0.91
17_Y 24_F 1.08 0.91
8_L 200_L 1.078 0.91
91_V 235_G 1.066 0.91
188_V 192_M 1.061 0.90
174_V 178_W 1.06 0.90
156_D 161_E 1.049 0.90
223_P 248_N 1.044 0.89
53_E 224_E 1.044 0.89
51_L 250_F 1.039 0.89
26_A 45_V 1.036 0.89
73_A 256_L 1.036 0.89
289_L 304_L 1.035 0.89
126_R 262_I 1.031 0.89
190_T 209_L 1.031 0.89
260_A 265_G 1.03 0.88
84_I 221_S 1.03 0.88
27_S 40_I 1.028 0.88
182_A 185_I 1.028 0.88
7_L 192_M 1.026 0.88
174_V 177_L 1.021 0.88
18_S 42_M 1.019 0.88
213_L 312_W 1.013 0.87
286_F 290_C 1.013 0.87
221_S 251_N 1.013 0.87
221_S 250_F 1.012 0.87
300_G 304_L 1.012 0.87
30_C 37_P 1.01 0.87
6_A 13_L 1.009 0.87
53_E 80_N 1.007 0.87
50_S 77_N 1.003 0.87
9_I 13_L 1.002 0.87
74_L 256_L 1 0.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3v5uA10.94461000.208Contact Map0.563
4k1cA20.97541000.27Contact Map0.544
4kjrA20.95691000.28Contact Map0.553
4kppA20.97231000.296Contact Map0.57
2kncA10.15699.40.964Contact Map0.553
2l8sA10.14773.30.971Contact Map0.386
4j05A20.56622.70.972Contact Map0.328
3o7qA10.53542.40.973Contact Map0.266
2jlnA10.52622.30.973Contact Map0.179
3giaA10.470820.974Contact Map0.501
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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