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OPENSEQ.org
TDCE - PFL-like enzyme TdcE
UniProt: P42632 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12758
Length: 764 (747)
Sequences: 764
Seq/Len: 1.02
TDCE
Paralog alert: 0.50 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: PFLB PFLD PFLF TDCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
293_E 297_K 3.618 1.00
420_A 430_I 3.431 1.00
722_D 726_H 3.282 1.00
477_Y 581_I 3.247 1.00
140_Y 144_D 3.184 1.00
576_E 658_K 2.841 1.00
539_D 644_R 2.825 1.00
301_L 306_A 2.633 1.00
289_D 293_E 2.568 0.99
494_Q 498_A 2.517 0.99
226_E 246_G 2.462 0.99
124_K 139_E 2.42 0.99
242_A 249_I 2.416 0.99
462_Q 465_P 2.413 0.99
42_E 352_T 2.389 0.99
281_L 313_F 2.389 0.99
35_Q 347_G 2.366 0.99
302_N 305_Q 2.351 0.99
242_A 265_F 2.335 0.99
623_N 629_R 2.324 0.99
256_A 292_I 2.268 0.98
256_A 306_A 2.263 0.98
40_P 352_T 2.192 0.98
292_I 306_A 2.162 0.98
260_V 310_I 2.128 0.97
347_G 351_R 2.11 0.97
462_Q 466_K 2.08 0.97
249_I 265_F 2.078 0.97
366_H 398_V 2.075 0.97
574_N 654_T 2.07 0.97
240_E 243_A 2.062 0.97
292_I 309_L 2.012 0.96
17_L 298_A 2.006 0.96
467_T 487_F 2.005 0.96
114_L 123_I 1.995 0.96
85_T 89_H 1.995 0.96
28_I 196_Y 1.991 0.95
255_N 300_V 1.991 0.95
749_R 753_Q 1.964 0.95
21_G 25_K 1.952 0.95
489_D 592_K 1.951 0.95
536_V 624_T 1.938 0.95
296_F 301_L 1.935 0.95
717_R 721_L 1.917 0.94
54_A 100_K 1.916 0.94
561_D 629_R 1.912 0.94
260_V 309_L 1.907 0.94
363_H 391_Y 1.899 0.94
306_A 309_L 1.894 0.94
724_I 753_Q 1.889 0.94
245_Y 265_F 1.887 0.94
294_R 298_A 1.883 0.93
284_T 361_Y 1.85 0.93
94_I 225_R 1.845 0.92
168_G 620_K 1.834 0.92
53_P 57_E 1.834 0.92
84_T 88_A 1.826 0.92
366_H 395_V 1.824 0.92
386_I 390_K 1.824 0.92
724_I 749_R 1.816 0.92
22_T 25_K 1.815 0.92
273_S 513_A 1.8 0.91
393_A 691_V 1.784 0.91
240_E 244_K 1.78 0.91
45_E 391_Y 1.776 0.90
238_I 514_S 1.769 0.90
550_K 563_E 1.736 0.89
401_S 416_S 1.73 0.89
57_E 98_L 1.728 0.89
35_Q 38_Y 1.725 0.89
195_S 250_S 1.721 0.89
571_Y 670_Y 1.706 0.88
247_F 254_Q 1.706 0.88
20_K 36_H 1.699 0.88
542_S 577_R 1.692 0.87
159_P 206_A 1.689 0.87
485_D 592_K 1.685 0.87
166_K 461_I 1.68 0.87
537_A 585_L 1.674 0.87
164_C 494_Q 1.672 0.87
161_M 498_A 1.659 0.86
199_R 203_L 1.656 0.86
253_A 262_W 1.652 0.86
45_E 387_A 1.648 0.86
464_G 487_F 1.645 0.85
499_L 529_C 1.637 0.85
23_D 29_N 1.63 0.85
195_S 251_R 1.621 0.84
427_P 661_F 1.617 0.84
200_E 204_Q 1.616 0.84
85_T 88_A 1.607 0.84
251_R 254_Q 1.603 0.83
94_I 104_L 1.586 0.82
202_E 206_A 1.583 0.82
598_T 602_A 1.583 0.82
346_M 352_T 1.58 0.82
470_L 479_K 1.567 0.81
54_A 312_H 1.565 0.81
567_E 570_Q 1.565 0.81
100_K 312_H 1.561 0.81
538_T 582_A 1.546 0.80
563_E 629_R 1.543 0.80
722_D 729_K 1.543 0.80
21_G 36_H 1.54 0.80
307_Q 311_D 1.539 0.80
42_E 353_L 1.537 0.80
38_Y 347_G 1.533 0.79
307_Q 360_R 1.524 0.79
446_T 488_M 1.518 0.78
670_Y 707_G 1.497 0.77
354_V 388_F 1.495 0.77
451_I 559_A 1.494 0.77
31_R 35_Q 1.493 0.77
198_V 232_R 1.484 0.76
65_G 76_V 1.483 0.76
472_D 479_K 1.481 0.76
78_F 82_I 1.48 0.76
161_M 501_I 1.473 0.75
670_Y 710_L 1.469 0.75
546_Y 555_E 1.469 0.75
653_L 710_L 1.451 0.74
474_V 550_K 1.445 0.73
241_M 265_F 1.444 0.73
473_D 550_K 1.441 0.73
91_A 244_K 1.438 0.73
204_Q 521_R 1.437 0.73
271_V 320_V 1.424 0.72
32_D 36_H 1.413 0.71
366_H 391_Y 1.413 0.71
652_S 670_Y 1.411 0.71
478_D 481_M 1.405 0.70
203_L 207_D 1.402 0.70
255_N 301_L 1.394 0.70
237_Q 513_A 1.391 0.69
396_S 404_Y 1.388 0.69
455_V 462_Q 1.382 0.69
284_T 288_L 1.379 0.68
460_K 554_D 1.373 0.68
227_E 231_H 1.373 0.68
332_F 506_H 1.369 0.68
464_G 467_T 1.366 0.67
247_F 251_R 1.366 0.67
241_M 249_I 1.363 0.67
358_S 388_F 1.357 0.67
284_T 341_E 1.354 0.66
697_Y 707_G 1.352 0.66
477_Y 545_K 1.35 0.66
22_T 36_H 1.347 0.66
100_K 309_L 1.345 0.66
669_S 709_H 1.344 0.65
259_A 291_Y 1.341 0.65
117_F 142_F 1.331 0.64
199_R 202_E 1.331 0.64
228_L 521_R 1.328 0.64
62_V 66_I 1.32 0.63
102_V 241_M 1.32 0.63
155_D 233_H 1.314 0.63
485_D 588_R 1.313 0.63
592_K 595_A 1.308 0.62
295_D 300_V 1.301 0.62
726_H 729_K 1.301 0.62
260_V 313_F 1.3 0.62
748_T 751_Q 1.296 0.61
480_V 541_L 1.291 0.61
194_I 238_I 1.288 0.61
740_Y 747_L 1.282 0.60
474_V 551_P 1.28 0.60
587_E 663_Y 1.278 0.60
72_T 76_V 1.277 0.60
428_M 519_H 1.265 0.59
217_D 416_S 1.265 0.59
536_V 626_D 1.265 0.59
494_Q 497_S 1.262 0.58
447_L 544_I 1.261 0.58
81_N 135_D 1.257 0.58
285_A 358_S 1.256 0.58
723_A 733_L 1.256 0.58
310_I 357_N 1.256 0.58
641_M 644_R 1.255 0.58
198_V 222_I 1.248 0.57
578_V 644_R 1.244 0.57
28_I 684_P 1.243 0.57
340_T 403_Q 1.242 0.56
653_L 670_Y 1.24 0.56
339_A 368_M 1.235 0.56
49_A 304_Q 1.228 0.55
256_A 357_N 1.227 0.55
640_P 740_Y 1.227 0.55
242_A 251_R 1.222 0.55
453_G 466_K 1.221 0.55
536_V 635_A 1.22 0.54
483_S 487_F 1.209 0.53
312_H 315_M 1.207 0.53
447_L 480_V 1.203 0.53
45_E 687_K 1.196 0.52
467_T 483_S 1.196 0.52
28_I 71_A 1.196 0.52
244_K 247_F 1.194 0.52
15_A 18_G 1.189 0.52
204_Q 207_D 1.188 0.51
292_I 357_N 1.186 0.51
645_D 759_T 1.183 0.51
25_K 36_H 1.182 0.51
709_H 713_N 1.179 0.51
68_I 72_T 1.178 0.51
102_V 265_F 1.177 0.50
575_D 578_V 1.174 0.50
301_L 309_L 1.169 0.50
649_A 672_F 1.168 0.50
163_R 461_I 1.168 0.50
614_N 754_D 1.166 0.49
410_M 419_Y 1.165 0.49
451_I 480_V 1.164 0.49
99_E 316_K 1.157 0.49
412_T 419_Y 1.155 0.48
38_Y 286_S 1.153 0.48
23_D 36_H 1.15 0.48
359_F 387_A 1.149 0.48
23_D 27_E 1.148 0.48
226_E 242_A 1.147 0.48
390_K 688_T 1.146 0.48
752_Q 756_I 1.146 0.48
54_A 73_H 1.142 0.47
654_T 700_H 1.139 0.47
31_R 347_G 1.134 0.46
470_L 559_A 1.127 0.46
83_A 123_I 1.127 0.46
664_A 754_D 1.123 0.45
340_T 377_T 1.121 0.45
161_M 494_Q 1.121 0.45
53_P 56_T 1.119 0.45
45_E 394_Q 1.116 0.45
285_A 341_E 1.114 0.45
99_E 102_V 1.114 0.45
235_L 239_Q 1.114 0.45
485_D 584_D 1.112 0.44
379_L 407_D 1.11 0.44
378_I 388_F 1.109 0.44
480_V 544_I 1.108 0.44
100_K 257_Q 1.107 0.44
257_Q 305_Q 1.105 0.44
66_I 94_I 1.102 0.43
27_E 36_H 1.098 0.43
234_A 237_Q 1.098 0.43
322_F 499_L 1.095 0.43
458_K 630_A 1.092 0.43
289_D 355_T 1.091 0.42
354_V 384_L 1.09 0.42
68_I 76_V 1.09 0.42
211_R 214_K 1.089 0.42
400_S 592_K 1.089 0.42
265_F 269_A 1.087 0.42
247_F 258_E 1.086 0.42
35_Q 40_P 1.084 0.42
446_T 487_F 1.084 0.42
470_L 474_V 1.083 0.42
229_A 402_L 1.083 0.42
281_L 284_T 1.08 0.41
36_H 42_E 1.08 0.41
640_P 667_G 1.08 0.41
310_I 361_Y 1.078 0.41
21_G 27_E 1.077 0.41
718_E 721_L 1.076 0.41
225_R 241_M 1.076 0.41
15_A 254_Q 1.076 0.41
450_A 480_V 1.076 0.41
68_I 71_A 1.075 0.41
189_V 266_A 1.073 0.41
558_L 562_F 1.071 0.41
322_F 754_D 1.07 0.41
77_D 108_A 1.069 0.40
295_D 301_L 1.066 0.40
94_I 110_L 1.066 0.40
128_H 139_E 1.065 0.40
551_P 558_L 1.063 0.40
737_V 755_V 1.063 0.40
15_A 117_F 1.061 0.40
20_K 28_I 1.061 0.40
128_H 133_E 1.06 0.40
54_A 98_L 1.058 0.39
54_A 63_M 1.057 0.39
743_R 746_A 1.057 0.39
451_I 470_L 1.057 0.39
194_I 266_A 1.054 0.39
194_I 239_Q 1.054 0.39
39_T 46_S 1.053 0.39
244_K 258_E 1.052 0.39
54_A 66_I 1.052 0.39
296_F 303_E 1.051 0.39
453_G 468_A 1.049 0.39
649_A 653_L 1.048 0.39
96_Q 764_L 1.048 0.39
62_V 76_V 1.046 0.38
237_Q 240_E 1.046 0.38
552_I 556_N 1.045 0.38
21_G 26_N 1.045 0.38
338_W 375_N 1.043 0.38
192_Y 200_E 1.043 0.38
66_I 76_V 1.043 0.38
467_T 474_V 1.042 0.38
277_G 322_F 1.042 0.38
538_T 578_V 1.041 0.38
314_I 361_Y 1.04 0.38
62_V 319_M 1.039 0.38
130_Y 530_G 1.037 0.38
546_Y 568_Y 1.035 0.37
110_L 321_R 1.035 0.37
524_Y 603_V 1.034 0.37
114_L 323_L 1.033 0.37
364_T 368_M 1.031 0.37
94_I 241_M 1.029 0.37
709_H 720_L 1.029 0.37
636_P 738_S 1.028 0.37
201_R 523_V 1.028 0.37
545_K 554_D 1.026 0.37
123_I 127_F 1.025 0.37
239_Q 250_S 1.024 0.36
395_V 398_V 1.023 0.36
20_K 23_D 1.023 0.36
460_K 558_L 1.022 0.36
709_H 759_T 1.022 0.36
162_L 206_A 1.021 0.36
649_A 670_Y 1.018 0.36
78_F 323_L 1.018 0.36
516_M 522_D 1.017 0.36
444_A 536_V 1.016 0.36
60_E 64_E 1.015 0.36
303_E 363_H 1.013 0.36
14_D 17_L 1.012 0.35
546_Y 577_R 1.012 0.35
698_F 707_G 1.012 0.35
607_S 666_D 1.011 0.35
562_F 623_N 1.011 0.35
54_A 315_M 1.011 0.35
17_L 684_P 1.01 0.35
73_H 82_I 1.009 0.35
293_E 710_L 1.006 0.35
479_K 483_S 1.005 0.35
64_E 67_R 1.003 0.35
98_L 574_N 1.003 0.35
23_D 45_E 1.003 0.35
117_F 285_A 1.002 0.35
15_A 36_H 1 0.34
661_F 668_I 1 0.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1h16A10.99351000.081Contact Map0.634
1r9dA20.91881000.188Contact Map0.594
2f3oA20.90971000.191Contact Map0.61
2y8nA20.95031000.199Contact Map0.597
1h7bA10.675499.60.944Contact Map0.542
1irqA20.081221.50.989Contact Map1
2o8rA20.090316.60.99Contact Map0.476
1xlyA20.109916.60.99Contact Map0.188
3ajfA40.116514.30.99Contact Map0.124
1xdpA20.085111.80.991Contact Map0.465
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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