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RLMG - Ribosomal RNA large subunit methyltransferase G
UniProt: P42596 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12726
Length: 378 (373)
Sequences: 400
Seq/Len: 1.07
RLMG
Paralog alert: 0.75 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: RLMG RSMC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
246_L 303_L 3.18 1.00
320_W 349_K 2.809 1.00
243_G 257_F 2.421 0.99
233_V 299_F 2.379 0.99
232_I 246_L 2.219 0.98
269_R 282_R 2.128 0.98
358_T 370_K 1.985 0.96
335_E 370_K 1.88 0.94
5_D 10_S 1.745 0.90
257_F 268_S 1.733 0.90
266_A 269_R 1.729 0.90
244_L 271_N 1.651 0.87
245_T 249_K 1.603 0.84
231_E 254_K 1.484 0.77
47_P 108_G 1.479 0.77
219_F 363_N 1.478 0.77
203_N 210_R 1.476 0.77
244_L 277_P 1.475 0.77
74_Y 293_G 1.474 0.77
159_L 176_C 1.474 0.77
323_F 350_L 1.47 0.77
351_K 357_C 1.457 0.76
72_D 261_S 1.443 0.75
304_C 338_I 1.434 0.74
224_L 246_L 1.428 0.74
317_N 321_E 1.427 0.73
342_R 345_D 1.401 0.72
32_D 56_G 1.388 0.70
308_F 341_N 1.377 0.70
323_F 342_R 1.368 0.69
236_G 258_V 1.366 0.69
35_L 236_G 1.353 0.68
62_L 254_K 1.352 0.68
232_I 253_A 1.352 0.68
341_N 344_L 1.352 0.68
308_F 344_L 1.351 0.68
337_Y 370_K 1.346 0.67
155_F 373_K 1.342 0.67
80_T 242_I 1.336 0.66
206_N 304_C 1.332 0.66
148_H 151_T 1.314 0.64
115_P 121_L 1.309 0.64
199_W 236_G 1.302 0.63
54_A 140_A 1.298 0.63
265_V 359_T 1.288 0.62
217_A 242_I 1.287 0.62
236_G 253_A 1.286 0.62
119_A 122_E 1.286 0.62
170_K 235_L 1.286 0.62
243_G 255_V 1.28 0.61
111_L 225_P 1.274 0.61
246_L 253_A 1.274 0.61
177_T 241_V 1.27 0.60
14_Q 20_D 1.255 0.59
224_L 265_V 1.251 0.59
74_Y 78_L 1.251 0.59
286_M 294_V 1.241 0.58
51_L 145_R 1.24 0.58
199_W 244_L 1.238 0.58
4_L 90_D 1.234 0.57
147_I 275_N 1.232 0.57
256_V 286_M 1.23 0.57
145_R 217_A 1.229 0.57
313_A 319_A 1.225 0.56
36_L 58_L 1.223 0.56
115_P 261_S 1.22 0.56
51_L 124_Q 1.216 0.55
92_S 142_A 1.214 0.55
144_A 147_I 1.213 0.55
217_A 290_A 1.211 0.55
52_N 120_L 1.21 0.55
117_T 206_N 1.209 0.55
53_D 58_L 1.209 0.55
2_S 21_D 1.207 0.55
132_V 136_T 1.204 0.54
14_Q 18_A 1.198 0.54
106_Q 133_T 1.197 0.54
14_Q 19_T 1.195 0.54
236_G 288_N 1.194 0.53
222_Q 363_N 1.192 0.53
253_A 335_E 1.191 0.53
9_R 21_D 1.19 0.53
169_K 271_N 1.19 0.53
275_N 315_T 1.189 0.53
347_F 367_V 1.188 0.53
47_P 105_Q 1.184 0.52
304_C 319_A 1.183 0.52
243_G 253_A 1.181 0.52
215_I 365_K 1.178 0.52
300_N 331_K 1.177 0.52
241_V 251_P 1.171 0.51
41_D 241_V 1.169 0.51
3_H 7_G 1.165 0.51
174_I 208_F 1.162 0.50
143_K 171_A 1.16 0.50
144_A 167_A 1.157 0.50
20_D 24_P 1.154 0.50
35_L 328_R 1.153 0.50
203_N 263_M 1.153 0.50
29_E 145_R 1.148 0.49
250_N 365_K 1.147 0.49
152_L 174_I 1.146 0.49
345_D 351_K 1.144 0.49
232_I 279_A 1.142 0.49
316_D 365_K 1.142 0.49
143_K 147_I 1.141 0.48
247_L 337_Y 1.137 0.48
333_N 337_Y 1.136 0.48
83_N 218_R 1.13 0.47
145_R 194_L 1.128 0.47
16_F 91_E 1.128 0.47
359_T 362_T 1.127 0.47
35_L 139_I 1.124 0.47
144_A 150_S 1.124 0.47
227_N 243_G 1.122 0.47
53_D 322_M 1.119 0.46
231_E 331_K 1.118 0.46
316_D 340_A 1.117 0.46
173_L 178_F 1.112 0.46
265_V 269_R 1.111 0.46
58_L 333_N 1.111 0.46
150_S 164_T 1.103 0.45
193_K 200_T 1.097 0.44
206_N 263_M 1.096 0.44
292_S 368_V 1.093 0.44
113_K 174_I 1.092 0.44
302_V 326_A 1.091 0.44
36_L 115_P 1.09 0.44
15_R 25_L 1.089 0.44
246_L 301_A 1.089 0.44
1_M 21_D 1.086 0.43
113_K 218_R 1.083 0.43
35_L 67_P 1.083 0.43
220_F 303_L 1.079 0.43
290_A 321_E 1.078 0.43
86_L 135_D 1.075 0.42
231_E 256_V 1.074 0.42
52_N 279_A 1.073 0.42
51_L 128_L 1.073 0.42
7_G 281_D 1.072 0.42
223_H 361_A 1.068 0.42
85_R 177_T 1.064 0.41
155_F 176_C 1.063 0.41
354_F 367_V 1.062 0.41
299_F 329_C 1.058 0.41
145_R 170_K 1.057 0.41
269_R 273_E 1.057 0.41
21_D 24_P 1.056 0.41
8_F 12_T 1.054 0.40
33_E 371_A 1.053 0.40
142_A 208_F 1.052 0.40
33_E 169_K 1.051 0.40
13_L 27_A 1.048 0.40
7_G 37_Q 1.045 0.40
47_P 107_P 1.045 0.40
19_T 22_V 1.045 0.40
90_D 284_E 1.045 0.40
191_S 200_T 1.044 0.39
49_L 132_V 1.043 0.39
242_I 339_V 1.042 0.39
73_S 350_L 1.041 0.39
10_S 20_D 1.04 0.39
272_V 279_A 1.036 0.39
13_L 25_L 1.035 0.39
12_T 16_F 1.033 0.38
117_T 300_N 1.033 0.38
98_D 101_A 1.032 0.38
7_G 295_E 1.032 0.38
57_A 83_N 1.031 0.38
341_N 346_Y 1.03 0.38
138_I 159_L 1.03 0.38
7_G 19_T 1.03 0.38
247_L 277_P 1.029 0.38
82_E 180_E 1.029 0.38
159_L 257_F 1.028 0.38
73_S 260_E 1.028 0.38
62_L 286_M 1.024 0.38
109_V 139_I 1.023 0.38
1_M 250_N 1.023 0.38
138_I 333_N 1.023 0.38
336_L 366_F 1.021 0.37
112_I 302_V 1.018 0.37
19_T 339_V 1.017 0.37
232_I 297_F 1.017 0.37
18_A 220_F 1.016 0.37
36_L 268_S 1.016 0.37
33_E 58_L 1.015 0.37
52_N 110_V 1.015 0.37
232_I 294_V 1.013 0.37
19_T 24_P 1.013 0.37
171_A 340_A 1.011 0.36
53_D 170_K 1.011 0.36
147_I 152_L 1.01 0.36
113_K 144_A 1.01 0.36
31_A 87_N 1.008 0.36
230_G 339_V 1.006 0.36
128_L 136_T 1.001 0.36
190_V 241_V 1.001 0.36
263_M 319_A 1 0.36
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4dcmA10.98151000.376Contact Map0.424
2pjdA10.89421000.483Contact Map0.375
3dmgA10.94441000.517Contact Map0.4
1dusA10.505399.90.786Contact Map0.541
2ozvA20.486899.90.821Contact Map0.546
3lpmA20.515999.80.827Contact Map0.491
2b3tA10.637699.80.829Contact Map0.473
4dzrA10.452499.80.834Contact Map0.43
3evzA10.526599.80.835Contact Map0.546
3b3jA10.761999.80.835Contact Map0.484
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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