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OPENSEQ.org
MENF - Menaquinone-specific isochorismate synthase
UniProt: P38051 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12362
Length: 431 (420)
Sequences: 776
Seq/Len: 1.85
MENF
Paralog alert: 0.38 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: ENTC MENF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
258_T 316_V 3.424 1.00
261_N 268_A 3.222 1.00
300_T 325_T 3.082 1.00
180_T 407_G 2.891 1.00
283_R 287_L 2.691 1.00
272_G 310_V 2.646 1.00
345_V 369_A 2.637 1.00
278_D 281_N 2.56 1.00
197_T 421_A 2.463 1.00
198_D 397_R 2.453 1.00
173_T 411_E 2.303 1.00
253_E 320_R 2.299 1.00
195_R 417_I 2.266 1.00
262_N 267_Q 2.179 0.99
279_D 283_R 2.169 0.99
346_A 354_R 2.138 0.99
356_F 360_H 1.992 0.99
333_V 336_L 1.816 0.97
224_F 236_G 1.816 0.97
281_N 412_Q 1.803 0.97
224_F 388_S 1.728 0.96
376_S 379_Q 1.689 0.95
194_A 368_Y 1.674 0.95
97_L 367_W 1.637 0.94
271_L 317_Q 1.619 0.94
302_T 326_S 1.603 0.93
218_N 423_G 1.593 0.93
201_F 205_V 1.589 0.93
196_A 397_R 1.573 0.92
179_A 193_L 1.566 0.92
285_N 321_R 1.565 0.92
355_Q 359_R 1.564 0.92
332_D 380_S 1.554 0.92
69_A 72_R 1.547 0.92
261_N 386_L 1.546 0.92
176_I 180_T 1.543 0.91
389_A 396_V 1.537 0.91
183_I 406_R 1.521 0.91
288_V 343_A 1.45 0.88
188_L 356_F 1.411 0.86
335_C 386_L 1.381 0.84
194_A 363_F 1.379 0.84
249_A 324_W 1.378 0.84
171_G 174_Q 1.374 0.84
214_S 237_S 1.37 0.83
182_T 359_R 1.365 0.83
262_N 271_L 1.364 0.83
398_L 424_L 1.356 0.83
9_E 13_R 1.355 0.83
291_D 343_A 1.352 0.82
312_R 317_Q 1.344 0.82
184_A 407_G 1.335 0.81
172_W 402_A 1.331 0.81
248_K 326_S 1.331 0.81
268_A 386_L 1.327 0.81
66_V 366_E 1.324 0.80
333_V 378_Q 1.324 0.80
243_W 380_S 1.323 0.80
181_K 185_E 1.322 0.80
245_R 248_K 1.318 0.80
409_D 412_Q 1.306 0.79
218_N 221_C 1.304 0.79
243_W 250_L 1.303 0.79
177_E 181_K 1.301 0.79
293_C 305_V 1.294 0.78
292_I 323_I 1.289 0.78
191_V 357_I 1.267 0.76
299_D 338_Q 1.266 0.76
73_F 79_A 1.26 0.76
264_D 267_Q 1.253 0.75
412_Q 419_N 1.25 0.75
323_I 404_I 1.24 0.74
261_N 317_Q 1.237 0.74
332_D 336_L 1.233 0.73
371_S 385_S 1.223 0.73
288_V 384_V 1.22 0.72
42_S 46_S 1.219 0.72
190_K 344_A 1.217 0.72
205_V 396_V 1.211 0.72
413_E 416_E 1.211 0.72
96_G 107_L 1.203 0.71
42_S 238_S 1.202 0.71
177_E 410_P 1.202 0.71
80_Q 334_I 1.201 0.71
286_M 290_E 1.201 0.71
182_T 187_E 1.199 0.70
191_V 210_M 1.197 0.70
98_N 371_S 1.196 0.70
201_F 223_H 1.195 0.70
309_Q 322_C 1.191 0.70
243_W 332_D 1.19 0.70
310_V 317_Q 1.189 0.70
221_C 423_G 1.186 0.69
255_L 313_L 1.185 0.69
273_E 352_L 1.184 0.69
168_D 171_G 1.183 0.69
403_G 408_S 1.183 0.69
409_D 428_L 1.183 0.69
107_L 382_F 1.18 0.69
255_L 389_A 1.176 0.68
64_A 212_A 1.174 0.68
93_R 254_A 1.168 0.68
310_V 402_A 1.165 0.67
194_A 369_A 1.164 0.67
68_G 111_R 1.161 0.67
9_E 15_L 1.158 0.67
192_V 344_A 1.158 0.67
361_E 365_R 1.157 0.67
221_C 315_K 1.154 0.66
101_D 358_A 1.148 0.66
259_V 274_W 1.148 0.66
28_I 31_P 1.148 0.66
308_P 319_L 1.144 0.65
242_L 344_A 1.14 0.65
92_L 258_T 1.135 0.64
256_A 318_H 1.134 0.64
298_A 338_Q 1.127 0.64
218_N 315_K 1.126 0.63
173_T 414_W 1.121 0.63
333_V 374_Y 1.12 0.63
237_S 282_Q 1.118 0.63
9_E 17_Q 1.117 0.63
259_V 271_L 1.116 0.62
234_F 388_S 1.115 0.62
345_V 417_I 1.114 0.62
39_D 42_S 1.111 0.62
242_L 384_V 1.109 0.62
100_F 342_T 1.101 0.61
405_V 408_S 1.101 0.61
53_F 323_I 1.096 0.60
29_D 32_F 1.092 0.60
273_E 276_M 1.092 0.60
258_T 374_Y 1.091 0.60
413_E 420_K 1.09 0.60
236_G 374_Y 1.089 0.60
169_K 173_T 1.086 0.59
10_N 17_Q 1.086 0.59
288_V 344_A 1.084 0.59
221_C 320_R 1.083 0.59
250_L 300_T 1.081 0.59
244_R 424_L 1.08 0.59
270_Q 274_W 1.079 0.59
408_S 413_E 1.078 0.58
287_L 348_L 1.077 0.58
291_D 295_R 1.074 0.58
190_K 342_T 1.073 0.58
179_A 356_F 1.067 0.57
190_K 256_A 1.061 0.57
411_E 415_Q 1.06 0.57
190_K 403_G 1.058 0.56
244_R 381_E 1.058 0.56
96_G 382_F 1.057 0.56
100_F 236_G 1.056 0.56
44_L 58_R 1.054 0.56
190_K 242_L 1.052 0.56
256_A 344_A 1.051 0.56
10_N 14_H 1.051 0.56
180_T 184_A 1.05 0.55
371_S 374_Y 1.05 0.55
80_Q 222_Y 1.048 0.55
261_N 264_D 1.047 0.55
190_K 318_H 1.047 0.55
262_N 317_Q 1.046 0.55
269_Q 273_E 1.044 0.55
346_A 350_R 1.042 0.55
12_L 16_S 1.042 0.55
234_F 372_A 1.042 0.55
316_V 419_N 1.039 0.54
101_D 370_G 1.038 0.54
375_L 388_S 1.036 0.54
294_Q 301_Q 1.035 0.54
94_I 109_L 1.033 0.54
303_L 325_T 1.032 0.53
366_E 390_K 1.031 0.53
205_V 238_S 1.031 0.53
10_N 16_S 1.028 0.53
205_V 210_M 1.028 0.53
194_A 374_Y 1.026 0.53
23_P 32_F 1.026 0.53
254_A 288_V 1.022 0.52
275_L 278_D 1.022 0.52
402_A 417_I 1.018 0.52
28_I 125_L 1.017 0.52
222_Y 253_E 1.017 0.52
260_A 271_L 1.016 0.52
318_H 344_A 1.016 0.52
282_Q 307_P 1.016 0.52
54_Y 63_E 1.015 0.52
218_N 313_L 1.015 0.52
194_A 421_A 1.015 0.52
345_V 371_S 1.014 0.52
23_P 37_A 1.013 0.51
234_F 390_K 1.012 0.51
7_A 11_L 1.011 0.51
258_T 425_R 1.008 0.51
9_E 16_S 1.007 0.51
265_D 272_G 1.005 0.51
241_R 382_F 1.005 0.51
43_W 47_Q 1.003 0.50
245_R 327_L 1.003 0.50
242_L 256_A 1.001 0.50
63_E 116_R 1.001 0.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bzmA10.99541000.194Contact Map0.537
3gseA111000.2Contact Map0.518
3os6A40.86771000.286Contact Map0.625
3hwoA20.86081000.296Contact Map0.609
3logA40.9351000.333Contact Map0.571
3h9mA10.92111000.336Contact Map0.509
1qdlA10.88631000.347Contact Map0.595
2fn0A20.91881000.352Contact Map0.601
4grhA10.92811000.372Contact Map0.428
1k0eA20.91651000.38Contact Map0.555
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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