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OPENSEQ.org
DLGD - 2,3-diketo-L-gulonate reductase
UniProt: P37672 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12279
Length: 332 (332)
Sequences: 933
Seq/Len: 2.81
DLGD
Paralog alert: 0.57 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ALLD DLGD YBIC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
81_A 89_T 3.882 1.00
124_G 160_I 3.717 1.00
68_K 82_Q 3.202 1.00
149_A 291_A 3.082 1.00
198_G 212_I 2.86 1.00
289_T 305_H 2.701 1.00
313_E 317_N 2.64 1.00
9_K 31_E 2.622 1.00
293_R 300_I 2.498 1.00
94_M 127_A 2.43 1.00
95_D 126_Q 2.308 1.00
151_E 292_E 2.273 1.00
192_Q 209_P 2.269 1.00
74_G 104_H 2.265 1.00
62_I 82_Q 2.232 1.00
192_Q 207_K 2.232 1.00
208_E 211_V 2.222 1.00
128_A 162_A 2.21 1.00
296_E 299_A 2.079 1.00
72_S 100_L 2.076 1.00
102_A 130_K 2.045 1.00
70_I 80_D 1.977 1.00
77_E 109_V 1.926 0.99
323_D 327_A 1.923 0.99
117_W 136_C 1.904 0.99
65_A 82_Q 1.889 0.99
162_A 170_M 1.887 0.99
145_P 217_R 1.883 0.99
161_V 232_V 1.865 0.99
38_E 314_N 1.864 0.99
110_A 241_S 1.863 0.99
156_T 175_M 1.841 0.99
44_H 116_H 1.832 0.99
179_S 182_M 1.828 0.99
99_E 103_D 1.821 0.99
8_L 46_V 1.813 0.99
17_I 23_S 1.813 0.99
16_L 49_F 1.811 0.99
75_A 104_H 1.781 0.99
97_A 107_G 1.781 0.99
77_E 97_A 1.739 0.98
42_Y 314_N 1.727 0.98
48_R 181_G 1.721 0.98
37_T 42_Y 1.704 0.98
74_G 100_L 1.672 0.98
171_V 228_G 1.671 0.98
117_W 120_G 1.67 0.98
30_A 34_A 1.661 0.98
145_P 199_F 1.66 0.98
200_D 204_N 1.65 0.98
13_N 27_D 1.62 0.97
199_F 217_R 1.61 0.97
295_D 299_A 1.599 0.97
151_E 291_A 1.594 0.97
178_F 197_G 1.588 0.97
193_L 197_G 1.585 0.97
200_D 211_V 1.579 0.97
97_A 109_V 1.573 0.97
312_A 316_R 1.565 0.96
29_C 85_I 1.56 0.96
127_A 265_A 1.548 0.96
62_I 65_A 1.538 0.96
134_G 162_A 1.514 0.95
77_E 107_G 1.494 0.95
125_W 129_E 1.489 0.95
98_I 130_K 1.476 0.95
102_A 132_Y 1.471 0.94
187_R 210_G 1.463 0.94
267_E 270_K 1.461 0.94
10_A 14_R 1.452 0.94
116_H 181_G 1.449 0.94
314_N 320_T 1.449 0.94
25_T 88_L 1.429 0.93
143_V 180_Y 1.416 0.93
96_R 99_E 1.411 0.93
198_G 206_T 1.399 0.92
13_N 23_S 1.395 0.92
13_N 17_I 1.394 0.92
70_I 78_Q 1.379 0.91
5_F 38_E 1.374 0.91
12_F 49_F 1.371 0.91
90_A 263_F 1.36 0.91
80_D 113_N 1.348 0.90
96_R 100_L 1.345 0.90
95_D 99_E 1.335 0.90
114_A 261_Q 1.332 0.89
135_I 264_I 1.312 0.89
195_V 207_K 1.291 0.87
65_A 84_S 1.286 0.87
32_M 87_N 1.278 0.87
14_R 17_I 1.274 0.86
289_T 299_A 1.27 0.86
77_E 96_R 1.255 0.85
67_P 82_Q 1.239 0.84
159_L 233_L 1.234 0.84
132_Y 268_V 1.229 0.84
80_D 112_R 1.229 0.84
295_D 298_Q 1.226 0.84
186_N 193_L 1.224 0.83
15_V 53_I 1.218 0.83
9_K 13_N 1.205 0.82
31_E 122_S 1.202 0.82
23_S 27_D 1.197 0.81
176_S 230_S 1.195 0.81
81_A 111_L 1.186 0.81
322_D 325_V 1.184 0.80
96_R 109_V 1.177 0.80
154_I 230_S 1.173 0.80
163_I 232_V 1.167 0.79
43_S 182_M 1.162 0.79
201_D 214_K 1.159 0.78
94_M 126_Q 1.156 0.78
193_L 198_G 1.156 0.78
159_L 229_M 1.152 0.78
108_L 264_I 1.145 0.77
76_I 271_L 1.143 0.77
286_D 290_S 1.141 0.77
73_L 270_K 1.14 0.77
311_L 315_R 1.139 0.77
39_S 311_L 1.137 0.77
107_G 265_A 1.134 0.76
165_S 282_Q 1.132 0.76
48_R 116_H 1.124 0.75
144_M 217_R 1.123 0.75
235_M 277_R 1.114 0.75
26_A 30_A 1.102 0.73
106_I 264_I 1.101 0.73
146_P 227_S 1.089 0.72
125_W 311_L 1.083 0.72
44_H 181_G 1.083 0.72
46_V 321_V 1.075 0.71
8_L 319_I 1.071 0.70
173_M 229_M 1.07 0.70
293_R 299_A 1.067 0.70
22_D 64_D 1.062 0.69
94_M 265_A 1.059 0.69
12_F 16_L 1.055 0.69
234_D 238_T 1.053 0.68
94_M 134_G 1.053 0.68
98_I 101_A 1.051 0.68
91_K 126_Q 1.051 0.68
179_S 186_N 1.046 0.68
28_A 91_K 1.044 0.68
153_R 287_Y 1.038 0.67
9_K 27_D 1.033 0.66
144_M 175_M 1.025 0.65
31_E 321_V 1.025 0.65
237_A 260_S 1.025 0.65
244_A 258_G 1.019 0.65
5_F 34_A 1.012 0.64
108_L 262_I 1.01 0.64
144_M 176_S 1.004 0.63
77_E 100_L 1.002 0.63
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1nxuA211000.017Contact Map0.767
1v9nA111000.021Contact Map0.711
4h8aA20.9911000.021Contact Map0.751
1rfmA80.9881000.025Contact Map0.81
3i0pA111000.027Contact Map0.699
1vbiA10.9881000.027Contact Map0.643
3uoeA20.98491000.027Contact Map0.735
1z2iA40.9881000.037Contact Map0.73
1wtjA20.97591000.041Contact Map0.735
2g8yA20.9911000.042Contact Map0.748
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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