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MLRA - HTH-type transcriptional regulator MlrA
UniProt: P33358 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12008
Length: 243 (234)
Sequences: 470
Seq/Len: 2.01

MLRA
Paralog alert: 0.51 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: MLRA YCGE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
167_V 178_L 3.047 1.00
4_Y 44_D 2.251 1.00
12_L 51_R 2.215 1.00
48_D 51_R 2.133 0.99
129_Q 139_L 2.132 0.99
22_A 25_R 1.864 0.98
92_L 100_L 1.709 0.96
6_I 32_P 1.664 0.96
15_I 19_T 1.647 0.95
204_P 209_G 1.556 0.93
9_V 13_C 1.509 0.91
56_W 112_P 1.502 0.91
13_C 50_I 1.482 0.90
164_D 191_R 1.479 0.90
108_G 149_Y 1.45 0.89
139_L 173_Q 1.419 0.88
24_Q 32_P 1.408 0.87
6_I 24_Q 1.4 0.87
91_Y 95_G 1.389 0.86
16_N 63_V 1.382 0.86
140_A 143_D 1.373 0.85
9_V 47_I 1.37 0.85
15_I 36_D 1.349 0.84
20_L 25_R 1.348 0.84
10_A 22_A 1.344 0.84
13_C 37_G 1.331 0.83
22_A 34_R 1.328 0.83
129_Q 177_R 1.327 0.83
139_L 196_A 1.313 0.82
139_L 143_D 1.279 0.79
24_Q 147_I 1.275 0.79
66_V 70_L 1.275 0.79
53_I 56_W 1.27 0.79
140_A 177_R 1.27 0.79
165_A 185_A 1.269 0.79
41_L 146_L 1.268 0.79
9_V 30_L 1.248 0.77
56_W 70_L 1.246 0.77
173_Q 196_A 1.233 0.76
129_Q 196_A 1.225 0.75
22_A 32_P 1.225 0.75
8_E 162_G 1.224 0.75
225_Q 234_Q 1.22 0.75
154_L 183_W 1.217 0.74
29_L 53_I 1.206 0.73
55_R 192_I 1.204 0.73
102_T 197_H 1.203 0.73
225_Q 228_L 1.202 0.73
15_I 57_I 1.201 0.73
45_A 71_S 1.2 0.73
24_Q 34_R 1.192 0.72
129_Q 140_A 1.185 0.72
129_Q 143_D 1.183 0.71
6_I 18_V 1.183 0.71
226_Q 230_S 1.181 0.71
216_C 221_T 1.172 0.70
165_A 190_W 1.169 0.70
42_F 150_I 1.166 0.70
16_N 19_T 1.165 0.70
230_S 234_Q 1.165 0.70
50_I 158_R 1.155 0.69
39_H 66_V 1.146 0.68
20_L 117_T 1.143 0.68
53_I 70_L 1.142 0.68
168_V 196_A 1.137 0.67
13_C 16_N 1.137 0.67
22_A 41_L 1.134 0.67
140_A 200_N 1.133 0.67
89_L 127_R 1.127 0.66
53_I 66_V 1.124 0.66
111_Y 120_L 1.119 0.65
37_G 66_V 1.117 0.65
16_N 29_L 1.116 0.65
47_I 132_Q 1.116 0.65
187_Q 216_C 1.115 0.65
121_F 178_L 1.112 0.65
6_I 21_R 1.11 0.64
97_L 141_I 1.11 0.64
108_G 116_L 1.109 0.64
44_D 48_D 1.108 0.64
10_A 17_P 1.106 0.64
147_I 179_W 1.106 0.64
48_D 156_S 1.102 0.64
72_N 120_L 1.101 0.63
18_V 37_G 1.1 0.63
6_I 38_G 1.097 0.63
5_T 66_V 1.096 0.63
49_R 73_E 1.093 0.63
112_P 116_L 1.092 0.62
195_L 199_L 1.084 0.62
105_K 146_L 1.083 0.62
226_Q 233_E 1.081 0.61
16_N 64_S 1.077 0.61
37_G 57_I 1.077 0.61
16_N 22_A 1.069 0.60
21_R 26_R 1.066 0.60
6_I 42_F 1.065 0.60
128_L 140_A 1.064 0.59
9_V 20_L 1.057 0.59
225_Q 232_Q 1.057 0.59
53_I 63_V 1.057 0.59
140_A 196_A 1.055 0.59
158_R 163_K 1.053 0.58
125_R 143_D 1.051 0.58
34_R 38_G 1.049 0.58
162_G 185_A 1.048 0.58
24_Q 138_L 1.041 0.57
57_I 66_V 1.038 0.57
230_S 233_E 1.037 0.57
131_Q 138_L 1.035 0.56
18_V 66_V 1.03 0.56
7_G 18_V 1.028 0.56
168_V 214_V 1.025 0.55
22_A 70_L 1.025 0.55
61_V 70_L 1.025 0.55
19_T 22_A 1.021 0.55
167_V 171_N 1.019 0.55
52_E 67_K 1.019 0.55
19_T 39_H 1.016 0.54
88_L 157_A 1.015 0.54
22_A 38_G 1.014 0.54
140_A 173_Q 1.013 0.54
88_L 124_L 1.011 0.54
76_D 222_S 1.011 0.54
9_V 50_I 1.01 0.54
32_P 38_G 1.01 0.54
17_P 25_R 1.007 0.53
45_A 166_L 1.007 0.53
223_A 226_Q 1.006 0.53
32_P 41_L 1.006 0.53
10_A 131_Q 1.006 0.53
20_L 213_L 1.006 0.53
19_T 26_R 1.005 0.53
16_N 47_I 1.004 0.53
18_V 22_A 1.003 0.53
8_E 111_Y 1.002 0.53
135_L 199_L 1.001 0.53
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2i2xB80.806699.80.703Contact Map0.323
3ezxA10.670899.80.705Contact Map0.295
1y80A10.662699.70.708Contact Map0.526
4hh0A20.971299.70.71Contact Map0.276
3bulA10.687299.70.712Contact Map0.273
4jgiA20.658499.70.718Contact Map0.285
4hh3C10.736699.70.723Contact Map0.401
3hh0A40.57299.60.738Contact Map0.39
2jmlA10.316999.60.741Contact Map0.235
2vz4A10.440399.60.742Contact Map0.404

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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