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OPENSEQ.org
HEMN - Oxygen-independent coproporphyrinogen-III oxidase
UniProt: P32131 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11836
Length: 457 (446)
Sequences: 2745
Seq/Len: 6.15
HEMN
Paralog alert: 0.50 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: HEMN YGGW
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
90_E 129_L 4.288 1.00
87_D 125_R 3.514 1.00
227_K 276_F 3.189 1.00
94_V 133_N 2.975 1.00
426_T 429_G 2.94 1.00
90_E 125_R 2.866 1.00
223_A 272_E 2.821 1.00
233_N 292_R 2.808 1.00
199_R 235_D 2.77 1.00
65_L 73_K 2.63 1.00
187_D 190_F 2.619 1.00
417_D 424_Q 2.565 1.00
167_L 198_A 2.552 1.00
136_F 140_A 2.478 1.00
410_L 436_I 2.449 1.00
275_A 279_Q 2.44 1.00
84_Q 351_D 2.396 1.00
93_I 130_L 2.362 1.00
57_V 130_L 2.336 1.00
196_N 200_E 2.328 1.00
59_I 118_L 2.283 1.00
176_K 189_E 2.243 1.00
86_L 90_E 2.225 1.00
88_A 347_Y 2.222 1.00
119_N 122_Q 2.201 1.00
222_F 273_T 2.184 1.00
85_Y 326_V 2.181 1.00
364_T 367_D 2.181 1.00
234_P 282_Y 2.118 1.00
86_L 126_L 2.052 1.00
144_I 164_F 2.048 1.00
174_F 229_V 2.048 1.00
230_A 280_S 2.034 1.00
192_F 228_R 2.023 1.00
110_W 126_L 2.007 1.00
175_N 221_S 2.001 1.00
156_L 198_A 1.968 1.00
160_R 203_F 1.96 1.00
153_L 200_E 1.953 1.00
93_I 324_M 1.94 1.00
239_V 273_T 1.938 1.00
330_S 337_A 1.935 1.00
91_Q 94_V 1.914 1.00
124_S 128_K 1.913 1.00
83_D 125_R 1.883 1.00
176_K 188_E 1.871 1.00
205_S 295_D 1.864 1.00
171_V 191_I 1.863 1.00
213_G 266_K 1.851 1.00
230_A 276_F 1.845 1.00
94_V 129_L 1.828 1.00
83_D 122_Q 1.817 1.00
189_E 193_A 1.778 1.00
124_S 161_A 1.778 1.00
228_R 231_E 1.733 1.00
348_Q 352_E 1.726 1.00
262_S 265_Q 1.707 1.00
307_H 310_F 1.7 1.00
92_E 339_N 1.692 1.00
342_E 345_Q 1.687 1.00
276_F 280_S 1.674 1.00
245_L 248_I 1.668 1.00
55_L 105_V 1.664 1.00
158_H 162_E 1.661 1.00
410_L 439_C 1.659 1.00
220_E 223_A 1.652 1.00
178_V 221_S 1.629 1.00
116_T 159_L 1.627 1.00
385_Y 418_V 1.625 1.00
120_K 158_H 1.619 1.00
219_P 272_E 1.615 1.00
86_L 122_Q 1.61 1.00
274_I 290_F 1.605 1.00
223_A 276_F 1.578 0.99
54_S 312_G 1.568 0.99
88_A 351_D 1.559 0.99
425_V 433_I 1.548 0.99
208_I 229_V 1.547 0.99
223_A 227_K 1.542 0.99
178_V 225_T 1.54 0.99
218_T 221_S 1.512 0.99
177_E 221_S 1.501 0.99
193_A 196_N 1.499 0.99
206_T 235_D 1.498 0.99
82_A 119_N 1.494 0.99
37_G 40_A 1.486 0.99
224_F 227_K 1.477 0.99
108_L 136_F 1.474 0.99
130_L 136_F 1.472 0.99
373_V 383_L 1.468 0.99
72_N 327_S 1.467 0.99
175_N 178_V 1.459 0.99
155_V 159_L 1.451 0.99
283_Q 293_P 1.451 0.99
156_L 201_I 1.447 0.99
385_Y 397_A 1.434 0.99
149_R 185_E 1.433 0.99
192_F 196_N 1.417 0.98
199_R 233_N 1.415 0.98
350_V 356_A 1.406 0.98
227_K 231_E 1.399 0.98
224_F 228_R 1.393 0.98
110_W 123_I 1.39 0.98
380_N 430_R 1.388 0.98
219_P 265_Q 1.386 0.98
205_S 235_D 1.384 0.98
55_L 324_M 1.376 0.98
118_L 122_Q 1.376 0.98
377_L 423_I 1.371 0.98
177_E 180_R 1.369 0.98
171_V 174_F 1.366 0.98
265_Q 268_D 1.36 0.98
329_I 338_Q 1.352 0.98
338_Q 359_R 1.348 0.98
264_Q 268_D 1.342 0.98
153_L 197_H 1.336 0.98
165_N 205_S 1.336 0.98
173_D 178_V 1.334 0.98
408_A 412_K 1.33 0.97
366_D 399_Y 1.324 0.97
177_E 216_K 1.322 0.97
123_I 162_E 1.315 0.97
199_R 234_P 1.31 0.97
95_H 350_V 1.31 0.97
55_L 130_L 1.305 0.97
94_V 132_E 1.303 0.97
385_Y 422_G 1.301 0.97
219_P 223_A 1.295 0.97
374_I 437_C 1.293 0.97
38_E 42_L 1.289 0.97
182_V 214_L 1.285 0.97
157_D 161_A 1.281 0.97
369_I 388_I 1.28 0.97
124_S 162_E 1.273 0.96
91_Q 351_D 1.27 0.96
425_V 436_I 1.27 0.96
219_P 269_I 1.27 0.96
167_L 203_F 1.268 0.96
86_L 129_L 1.264 0.96
384_D 387_P 1.259 0.96
320_D 331_M 1.253 0.96
104_H 137_N 1.248 0.96
411_A 418_V 1.248 0.96
340_Q 349_Q 1.246 0.96
95_H 356_A 1.242 0.96
433_I 437_C 1.239 0.96
188_E 228_R 1.238 0.96
235_D 295_D 1.236 0.96
323_G 337_A 1.235 0.96
198_A 206_T 1.227 0.95
169_M 198_A 1.224 0.95
326_V 346_Y 1.223 0.95
199_R 206_T 1.221 0.95
86_L 118_L 1.221 0.95
241_N 266_K 1.22 0.95
272_E 276_F 1.217 0.95
144_I 159_L 1.215 0.95
226_L 276_F 1.21 0.95
188_E 192_F 1.203 0.95
175_N 224_F 1.203 0.95
229_V 237_L 1.199 0.95
190_F 193_A 1.186 0.94
409_P 439_C 1.183 0.94
340_Q 358_W 1.182 0.94
408_A 411_A 1.178 0.94
372_D 392_W 1.175 0.94
123_I 144_I 1.166 0.93
326_V 343_L 1.164 0.93
419_D 422_G 1.16 0.93
157_D 201_I 1.158 0.93
219_P 268_D 1.157 0.93
116_T 146_V 1.156 0.93
120_K 155_V 1.154 0.93
344_K 348_Q 1.15 0.93
174_F 225_T 1.15 0.93
275_A 427_A 1.146 0.93
89_L 324_M 1.141 0.92
20_G 456_V 1.139 0.92
59_I 326_V 1.139 0.92
389_E 395_H 1.127 0.92
195_L 232_L 1.127 0.92
176_K 180_R 1.122 0.92
195_L 234_P 1.119 0.91
197_H 200_E 1.118 0.91
386_A 390_K 1.106 0.91
90_E 94_V 1.106 0.91
217_Q 269_I 1.101 0.91
277_L 282_Y 1.097 0.90
93_I 133_N 1.093 0.90
343_L 347_Y 1.09 0.90
320_D 332_I 1.088 0.90
128_K 132_E 1.082 0.90
385_Y 423_I 1.081 0.90
419_D 424_Q 1.079 0.89
93_I 134_F 1.078 0.89
195_L 206_T 1.076 0.89
214_L 217_Q 1.068 0.89
110_W 142_I 1.062 0.88
270_L 284_F 1.051 0.88
154_D 158_H 1.05 0.88
271_Q 431_L 1.047 0.87
278_T 427_A 1.047 0.87
272_E 275_A 1.046 0.87
195_L 199_R 1.045 0.87
245_L 249_F 1.044 0.87
216_K 259_D 1.041 0.87
193_A 197_H 1.029 0.86
105_V 140_A 1.029 0.86
130_L 324_M 1.028 0.86
413_D 428_K 1.027 0.86
188_E 191_I 1.024 0.86
16_Y 413_D 1.022 0.86
210_L 229_V 1.021 0.86
267_L 431_L 1.017 0.85
174_F 228_R 1.015 0.85
384_D 421_K 1.011 0.85
237_L 277_L 1.009 0.85
256_K 259_D 1.006 0.84
434_R 437_C 1.005 0.84
195_L 208_I 1.001 0.84
146_V 151_I 1.001 0.84
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1oltA111000.242Contact Map0.733
1r30A20.748499.90.807Contact Map0.486
2qgqA80.632499.90.812Contact Map0.675
4jc0A20.724399.90.823Contact Map0.572
3t7vA10.713399.90.833Contact Map0.545
3iixA10.713399.80.841Contact Map0.56
2yx0A10.634699.80.852Contact Map0.519
2z2uA10.612799.70.868Contact Map0.512
1tv8A20.693799.60.876Contact Map0.578
3c8fA10.518699.40.886Contact Map0.506
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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