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OPENSEQ.org
PQQL - Probable zinc protease PqqL
UniProt: P31828 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11744
Length: 931 (899)
Sequences: 2154
Seq/Len: 2.40
PQQL
Paralog alert: 0.56 [within 20: 0.03] - ratio of genomes with paralogs
Cluster includes: PQQL PTRA
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
378_A 382_D 5.574 1.00
370_T 374_H 4.358 1.00
853_E 857_N 4.318 1.00
74_N 211_Q 4.205 1.00
356_N 359_D 4.139 1.00
634_D 638_A 4.074 1.00
234_D 237_E 3.817 1.00
367_E 370_T 3.728 1.00
210_A 214_Q 3.724 1.00
581_S 584_S 3.529 1.00
92_T 141_A 3.301 1.00
36_I 236_K 3.236 1.00
82_V 152_F 3.169 1.00
905_T 908_N 3.112 1.00
908_N 911_T 2.995 1.00
853_E 906_V 2.825 1.00
209_P 213_R 2.806 1.00
852_S 855_E 2.792 1.00
79_A 215_F 2.782 1.00
214_Q 218_R 2.735 1.00
239_L 243_K 2.719 1.00
369_A 373_Q 2.712 1.00
907_E 911_T 2.702 1.00
80_H 83_E 2.67 1.00
137_Q 241_L 2.662 1.00
91_K 149_A 2.636 1.00
80_H 84_H 2.619 1.00
645_I 682_A 2.544 1.00
625_Q 629_H 2.494 1.00
211_Q 214_Q 2.4 1.00
784_F 909_V 2.374 1.00
64_I 225_M 2.339 1.00
795_N 799_Q 2.337 1.00
475_A 479_A 2.308 1.00
316_R 380_E 2.295 1.00
558_P 561_Q 2.242 1.00
48_I 233_I 2.216 1.00
609_V 619_G 2.214 1.00
81_F 157_V 2.173 1.00
564_L 688_D 2.154 1.00
116_Y 123_V 2.154 1.00
81_F 212_L 2.135 1.00
791_D 855_E 2.124 1.00
795_N 800_A 2.041 0.99
548_A 705_F 2.033 0.99
911_T 915_Q 2.014 0.99
68_S 197_P 2.003 0.99
687_A 691_A 2.002 0.99
362_N 366_A 1.991 0.99
906_V 910_N 1.99 0.99
531_R 704_T 1.967 0.99
93_W 141_A 1.928 0.99
838_L 841_E 1.924 0.99
615_N 618_P 1.917 0.99
39_Q 45_R 1.898 0.99
229_V 242_I 1.894 0.99
638_A 641_Q 1.878 0.99
844_V 848_A 1.875 0.99
907_E 910_N 1.875 0.99
560_Q 688_D 1.844 0.99
895_T 899_Q 1.82 0.98
712_A 715_K 1.815 0.98
358_Q 362_N 1.807 0.98
114_N 117_T 1.802 0.98
776_P 908_N 1.798 0.98
479_A 483_E 1.794 0.98
561_Q 695_Q 1.785 0.98
143_F 146_W 1.778 0.98
611_A 619_G 1.772 0.98
842_V 845_K 1.76 0.98
116_Y 121_E 1.76 0.98
578_G 631_T 1.758 0.98
240_A 244_D 1.752 0.98
617_E 719_L 1.742 0.98
168_W 198_I 1.742 0.98
831_R 834_E 1.728 0.98
137_Q 244_D 1.717 0.98
837_T 841_E 1.717 0.98
92_T 145_E 1.712 0.97
285_L 364_L 1.691 0.97
534_L 711_V 1.689 0.97
83_E 114_N 1.681 0.97
868_D 898_E 1.675 0.97
86_M 150_A 1.663 0.97
561_Q 688_D 1.644 0.97
686_A 690_L 1.639 0.96
136_L 238_A 1.625 0.96
784_F 913_V 1.607 0.96
800_A 835_L 1.604 0.96
214_Q 217_Q 1.6 0.96
36_I 239_L 1.591 0.96
237_E 240_A 1.59 0.96
38_G 46_Y 1.585 0.96
369_A 372_D 1.583 0.95
81_F 164_I 1.582 0.95
548_A 703_I 1.571 0.95
797_R 804_Y 1.571 0.95
73_D 195_R 1.562 0.95
864_Q 902_K 1.555 0.95
587_R 590_A 1.554 0.95
899_Q 902_K 1.547 0.95
721_T 725_G 1.545 0.95
637_W 641_Q 1.535 0.94
281_N 352_A 1.533 0.94
718_A 721_T 1.53 0.94
77_G 83_E 1.529 0.94
77_G 80_H 1.527 0.94
479_A 482_K 1.522 0.94
533_I 704_T 1.521 0.94
77_G 84_H 1.517 0.94
237_E 241_L 1.509 0.94
580_L 588_W 1.507 0.94
777_T 915_Q 1.507 0.94
783_A 901_L 1.501 0.93
36_I 235_S 1.494 0.93
133_K 237_E 1.491 0.93
796_I 803_A 1.49 0.93
101_T 138_Q 1.486 0.93
899_Q 903_Q 1.486 0.93
83_E 117_T 1.484 0.93
115_A 160_E 1.483 0.93
523_S 531_R 1.481 0.93
845_K 849_K 1.479 0.93
80_H 114_N 1.472 0.93
688_D 691_A 1.471 0.93
578_G 629_H 1.464 0.92
145_E 148_N 1.464 0.92
230_V 408_T 1.46 0.92
45_R 226_T 1.46 0.92
171_H 198_I 1.454 0.92
546_I 707_I 1.451 0.92
154_K 158_D 1.447 0.92
229_V 238_A 1.446 0.92
765_K 840_N 1.445 0.92
128_L 139_V 1.444 0.92
348_F 364_L 1.444 0.92
64_I 147_S 1.439 0.91
856_L 906_V 1.436 0.91
787_A 909_V 1.428 0.91
580_L 625_Q 1.424 0.91
78_V 82_V 1.422 0.91
201_M 205_A 1.42 0.91
145_E 149_A 1.419 0.91
685_T 688_D 1.418 0.91
896_E 900_L 1.416 0.91
440_V 444_A 1.413 0.90
715_K 718_A 1.41 0.90
807_S 822_L 1.408 0.90
83_E 115_A 1.408 0.90
585_L 626_R 1.401 0.90
203_T 206_T 1.393 0.90
565_I 692_A 1.385 0.89
448_Q 452_K 1.384 0.89
37_T 45_R 1.383 0.89
83_E 804_Y 1.383 0.89
359_D 362_N 1.379 0.89
592_N 615_N 1.377 0.89
530_A 724_L 1.377 0.89
241_L 244_D 1.377 0.89
776_P 780_A 1.373 0.89
363_A 366_A 1.371 0.89
377_S 380_E 1.37 0.89
84_H 114_N 1.368 0.89
233_I 238_A 1.364 0.88
717_V 721_T 1.363 0.88
223_N 251_A 1.36 0.88
210_A 217_Q 1.359 0.88
781_L 916_Y 1.357 0.88
86_M 90_T 1.354 0.88
181_A 184_P 1.348 0.88
473_S 476_A 1.347 0.87
474_P 478_L 1.347 0.87
80_H 115_A 1.345 0.87
320_R 367_E 1.338 0.87
433_R 437_Q 1.336 0.87
785_N 808_S 1.335 0.87
366_A 370_T 1.334 0.87
84_H 117_T 1.334 0.87
80_H 117_T 1.333 0.87
116_Y 125_Q 1.331 0.87
478_L 482_K 1.33 0.87
114_N 797_R 1.329 0.87
68_S 198_I 1.325 0.86
137_Q 245_N 1.325 0.86
312_L 315_Q 1.324 0.86
722_R 725_G 1.324 0.86
85_M 212_L 1.319 0.86
617_E 621_Q 1.316 0.86
165_T 201_M 1.316 0.86
157_V 212_L 1.315 0.86
382_D 385_K 1.314 0.86
91_K 373_Q 1.314 0.86
115_A 199_G 1.312 0.86
793_R 798_E 1.303 0.85
84_H 115_A 1.294 0.84
802_G 835_L 1.284 0.84
783_A 904_M 1.283 0.84
687_A 690_L 1.282 0.84
780_A 904_M 1.282 0.84
119_Y 197_P 1.28 0.84
229_V 233_I 1.279 0.84
48_I 235_S 1.274 0.83
777_T 916_Y 1.272 0.83
565_I 569_N 1.27 0.83
50_P 235_S 1.269 0.83
714_D 717_V 1.268 0.83
827_C 835_L 1.267 0.83
579_E 629_H 1.266 0.83
776_P 900_L 1.262 0.82
558_P 695_Q 1.262 0.82
100_E 103_E 1.26 0.82
160_E 167_E 1.258 0.82
40_L 44_L 1.256 0.82
105_M 135_N 1.245 0.81
575_S 630_S 1.232 0.80
241_L 245_N 1.23 0.80
83_E 167_E 1.23 0.80
579_E 625_Q 1.229 0.80
860_Q 902_K 1.228 0.80
476_A 479_A 1.228 0.80
170_A 198_I 1.227 0.80
165_T 205_A 1.226 0.80
80_H 804_Y 1.226 0.80
90_T 152_F 1.225 0.80
143_F 147_S 1.224 0.80
850_G 910_N 1.224 0.80
363_A 367_E 1.22 0.79
286_Y 345_S 1.217 0.79
592_N 618_P 1.215 0.79
368_L 372_D 1.211 0.79
164_I 168_W 1.205 0.78
77_G 89_G 1.202 0.78
114_N 199_G 1.2 0.78
84_H 804_Y 1.2 0.78
442_S 446_K 1.199 0.78
718_A 722_R 1.198 0.78
42_N 67_G 1.197 0.78
428_Y 431_S 1.196 0.77
599_K 606_L 1.194 0.77
624_N 726_S 1.194 0.77
527_S 721_T 1.191 0.77
637_W 686_A 1.188 0.77
90_T 150_A 1.186 0.77
580_L 585_L 1.182 0.76
164_I 193_L 1.18 0.76
896_E 899_Q 1.18 0.76
844_V 914_K 1.178 0.76
99_I 113_V 1.176 0.76
75_E 211_Q 1.173 0.76
795_N 841_E 1.173 0.76
80_H 160_E 1.173 0.76
455_D 458_W 1.161 0.74
270_F 361_A 1.159 0.74
99_I 793_R 1.159 0.74
439_T 442_S 1.156 0.74
432_K 436_Q 1.155 0.74
709_G 712_A 1.155 0.74
96_N 99_I 1.153 0.74
793_R 802_G 1.153 0.74
369_A 684_F 1.153 0.74
857_N 860_Q 1.152 0.74
226_T 415_S 1.151 0.74
114_N 804_Y 1.15 0.73
67_G 123_V 1.15 0.73
442_S 445_E 1.149 0.73
846_R 851_I 1.148 0.73
84_H 160_E 1.147 0.73
544_L 709_G 1.147 0.73
287_Y 365_M 1.145 0.73
200_L 203_T 1.143 0.73
103_E 862_N 1.142 0.73
366_A 369_A 1.141 0.73
713_E 717_V 1.14 0.73
913_V 917_L 1.139 0.72
199_G 797_R 1.138 0.72
170_A 805_S 1.136 0.72
326_L 348_F 1.134 0.72
296_D 299_S 1.134 0.72
150_A 216_Y 1.132 0.72
679_N 683_Q 1.131 0.72
582_S 585_L 1.131 0.72
530_A 607_L 1.131 0.72
140_M 229_V 1.13 0.72
372_D 448_Q 1.123 0.71
306_W 344_Q 1.123 0.71
285_L 361_A 1.122 0.71
157_V 209_P 1.122 0.71
495_P 498_N 1.122 0.71
79_A 84_H 1.122 0.71
863_V 901_L 1.121 0.71
99_I 798_E 1.12 0.71
841_E 844_V 1.119 0.71
77_G 199_G 1.119 0.71
684_F 694_R 1.118 0.70
47_M 226_T 1.117 0.70
618_P 621_Q 1.114 0.70
285_L 717_V 1.113 0.70
185_F 457_F 1.11 0.70
213_R 217_Q 1.108 0.69
59_N 412_A 1.107 0.69
546_I 609_V 1.105 0.69
646_Q 650_T 1.105 0.69
117_T 797_R 1.104 0.69
549_V 606_L 1.104 0.69
66_T 70_Q 1.103 0.69
707_I 720_I 1.102 0.69
117_T 122_T 1.101 0.69
708_V 878_A 1.101 0.69
160_E 804_Y 1.1 0.69
81_F 85_M 1.1 0.69
546_I 616_P 1.1 0.69
218_R 255_A 1.099 0.69
841_E 845_K 1.099 0.69
83_E 160_E 1.097 0.68
825_F 839_A 1.096 0.68
443_L 447_W 1.095 0.68
217_Q 474_P 1.093 0.68
806_V 839_A 1.093 0.68
166_E 169_R 1.092 0.68
364_L 367_E 1.092 0.68
285_L 458_W 1.09 0.68
441_Q 445_E 1.089 0.68
779_M 900_L 1.087 0.67
98_V 101_T 1.085 0.67
75_E 203_T 1.085 0.67
144_S 148_N 1.085 0.67
82_V 212_L 1.083 0.67
66_T 227_F 1.082 0.67
67_G 77_G 1.08 0.67
80_H 167_E 1.08 0.67
236_K 899_Q 1.079 0.66
117_T 804_Y 1.078 0.66
290_P 890_D 1.077 0.66
140_M 241_L 1.076 0.66
792_L 839_A 1.075 0.66
38_G 239_L 1.075 0.66
525_T 531_R 1.075 0.66
120_D 145_E 1.07 0.66
57_Q 408_T 1.069 0.65
64_I 146_W 1.068 0.65
620_F 719_L 1.067 0.65
90_T 166_E 1.066 0.65
83_E 797_R 1.064 0.65
117_T 160_E 1.06 0.64
75_E 195_R 1.059 0.64
568_A 693_D 1.056 0.64
72_E 75_E 1.056 0.64
317_L 364_L 1.054 0.64
114_N 160_E 1.052 0.64
115_A 804_Y 1.051 0.64
634_D 686_A 1.048 0.63
221_Q 224_N 1.047 0.63
115_A 122_T 1.043 0.63
691_A 695_Q 1.043 0.63
126_V 146_W 1.04 0.62
529_G 620_F 1.039 0.62
79_A 117_T 1.039 0.62
568_A 692_A 1.038 0.62
88_N 793_R 1.037 0.62
544_L 613_T 1.037 0.62
364_L 606_L 1.036 0.62
85_M 106_G 1.035 0.62
780_A 912_A 1.033 0.62
172_Q 196_E 1.033 0.62
656_A 805_S 1.032 0.61
232_D 375_G 1.031 0.61
98_V 142_I 1.031 0.61
366_A 373_Q 1.028 0.61
80_H 797_R 1.027 0.61
900_L 903_Q 1.027 0.61
102_F 113_V 1.027 0.61
45_R 65_H 1.025 0.61
513_S 903_Q 1.025 0.61
428_Y 432_K 1.025 0.61
41_D 243_K 1.024 0.61
140_M 227_F 1.022 0.60
847_L 914_K 1.021 0.60
780_A 909_V 1.02 0.60
217_Q 252_N 1.019 0.60
182_R 286_Y 1.018 0.60
48_I 239_L 1.018 0.60
138_Q 142_I 1.016 0.60
445_E 448_Q 1.015 0.60
857_N 861_Q 1.015 0.60
835_L 839_A 1.015 0.60
84_H 199_G 1.015 0.60
258_R 261_P 1.014 0.59
79_A 83_E 1.014 0.59
101_T 139_V 1.013 0.59
243_K 247_S 1.012 0.59
910_N 914_K 1.012 0.59
776_P 903_Q 1.012 0.59
75_E 78_V 1.01 0.59
160_E 793_R 1.01 0.59
714_D 718_A 1.007 0.59
86_M 146_W 1.007 0.59
76_L 211_Q 1.007 0.59
117_T 199_G 1.005 0.58
834_E 837_T 1.005 0.58
116_Y 412_A 1 0.58
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1q2lA10.93451000.336Contact Map0.549
3cwwA20.94311000.377Contact Map0.615
4l3tA10.94521000.388Contact Map0.556
2fgeA20.94411000.391Contact Map0.575
3s5mA10.96131000.412Contact Map0.504
3eoqA20.43291000.623Contact Map0.55
3amiA20.46721000.628Contact Map0.575
1hr6B40.45541000.636Contact Map0.606
3go9A10.52091000.638Contact Map0.539
1pp9A20.46511000.645Contact Map0.577
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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