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OPENSEQ.org
YICO - Putative permease YicO
UniProt: P31440 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11691
Length: 444 (429)
Sequences: 1451
Seq/Len: 3.38
YICO
Paralog alert: 0.45 [within 20: 0.02] - ratio of genomes with paralogs
Cluster includes: PURP YGFQ YICO YJCD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
22_L 27_T 3.79 1.00
21_K 24_Q 3.687 1.00
80_G 335_V 3.685 1.00
171_N 177_M 3.674 1.00
75_G 302_S 3.383 1.00
276_V 324_V 3.283 1.00
29_V 332_L 3.065 1.00
413_C 433_A 3.048 1.00
56_A 101_F 3.04 1.00
328_G 333_T 2.993 1.00
33_L 336_V 2.883 1.00
77_I 338_G 2.841 1.00
17_S 23_P 2.829 1.00
22_L 332_L 2.807 1.00
35_A 328_G 2.717 1.00
390_I 411_S 2.599 1.00
123_V 127_L 2.59 1.00
22_L 29_V 2.559 1.00
421_R 424_D 2.558 1.00
87_V 316_A 2.437 1.00
73_G 342_L 2.345 1.00
244_V 308_F 2.335 1.00
88_A 337_V 2.322 1.00
208_V 362_A 2.305 1.00
284_D 288_K 2.197 1.00
47_V 69_C 2.179 1.00
425_L 430_V 2.174 1.00
339_V 343_L 2.132 1.00
28_T 31_T 2.12 1.00
416_K 424_D 2.117 1.00
33_L 37_M 2.109 1.00
35_A 333_T 2.083 1.00
116_G 246_L 2.082 1.00
193_F 364_I 2.08 1.00
25_H 330_T 2.055 1.00
76_S 338_G 2.028 1.00
374_L 392_T 2.015 1.00
165_T 189_G 1.969 1.00
188_L 215_T 1.95 1.00
191_L 218_C 1.92 1.00
21_K 84_N 1.916 1.00
159_L 397_F 1.901 1.00
77_I 335_V 1.871 0.99
382_F 386_V 1.858 0.99
196_I 211_S 1.857 0.99
197_T 386_V 1.85 0.99
200_S 369_L 1.849 0.99
163_K 175_L 1.837 0.99
112_Q 243_E 1.837 0.99
103_V 261_F 1.809 0.99
77_I 81_I 1.775 0.99
210_V 214_V 1.77 0.99
161_G 364_I 1.763 0.99
73_G 77_I 1.754 0.99
422_W 430_V 1.698 0.99
336_V 339_V 1.694 0.99
74_I 309_I 1.687 0.99
47_V 344_V 1.675 0.99
144_S 384_E 1.668 0.99
159_L 176_V 1.665 0.98
93_M 96_N 1.662 0.98
192_G 215_T 1.658 0.98
85_L 289_F 1.651 0.98
199_L 204_F 1.616 0.98
135_Y 139_S 1.61 0.98
377_V 385_S 1.593 0.98
198_V 418_C 1.581 0.98
170_A 175_L 1.58 0.98
168_I 398_T 1.568 0.98
19_L 84_N 1.568 0.98
231_Y 347_F 1.551 0.97
48_F 352_A 1.538 0.97
33_L 340_M 1.537 0.97
242_G 308_F 1.535 0.97
78_A 82_F 1.535 0.97
199_L 210_V 1.533 0.97
22_L 84_N 1.53 0.97
422_W 425_L 1.527 0.97
116_G 249_A 1.502 0.97
163_K 399_F 1.502 0.97
56_A 100_A 1.497 0.97
126_F 304_V 1.49 0.96
355_P 358_A 1.486 0.96
31_T 35_A 1.486 0.96
74_I 305_A 1.477 0.96
417_V 422_W 1.473 0.96
16_L 29_V 1.463 0.96
17_S 22_L 1.459 0.96
278_D 376_R 1.445 0.95
50_N 96_N 1.438 0.95
191_L 195_I 1.435 0.95
337_V 344_V 1.429 0.95
414_I 418_C 1.424 0.95
33_L 332_L 1.421 0.95
187_L 191_L 1.41 0.95
72_A 90_A 1.399 0.94
16_L 19_L 1.397 0.94
195_I 214_V 1.394 0.94
46_I 50_N 1.39 0.94
279_K 325_A 1.377 0.94
73_G 338_G 1.374 0.94
393_V 397_F 1.373 0.94
332_L 335_V 1.371 0.94
59_M 111_W 1.369 0.93
196_I 365_F 1.359 0.93
78_A 298_V 1.353 0.93
217_C 221_F 1.35 0.93
383_T 419_T 1.342 0.93
197_T 415_M 1.341 0.93
265_N 313_S 1.341 0.93
198_V 414_I 1.329 0.92
236_D 239_G 1.327 0.92
33_L 339_V 1.32 0.92
283_I 289_F 1.319 0.92
245_D 248_G 1.315 0.92
384_E 416_K 1.311 0.91
55_G 61_P 1.305 0.91
69_C 73_G 1.302 0.91
246_L 249_A 1.295 0.91
383_T 416_K 1.29 0.91
119_F 244_V 1.289 0.90
110_S 113_T 1.277 0.90
304_V 307_A 1.276 0.90
417_V 430_V 1.27 0.90
269_S 316_A 1.265 0.89
375_A 380_D 1.265 0.89
92_A 315_T 1.265 0.89
291_N 294_K 1.262 0.89
391_T 408_G 1.261 0.89
194_F 414_I 1.26 0.89
37_M 340_M 1.26 0.89
180_D 183_S 1.259 0.89
71_I 314_V 1.256 0.89
57_A 64_V 1.256 0.89
188_L 219_G 1.254 0.89
200_S 207_A 1.25 0.89
426_N 430_V 1.248 0.88
121_G 265_N 1.247 0.88
198_V 419_T 1.242 0.88
196_I 200_S 1.238 0.88
232_S 235_P 1.234 0.88
216_S 354_V 1.225 0.87
43_M 88_A 1.223 0.87
282_L 316_A 1.222 0.87
162_L 364_I 1.217 0.87
85_L 291_N 1.207 0.86
201_S 386_V 1.204 0.86
200_S 365_F 1.189 0.85
192_G 361_G 1.188 0.85
437_A 441_I 1.181 0.84
134_R 299_D 1.181 0.84
367_G 389_F 1.174 0.84
126_F 300_S 1.173 0.84
148_G 377_V 1.159 0.83
17_S 332_L 1.153 0.83
196_I 208_V 1.151 0.82
218_C 222_F 1.15 0.82
195_I 218_C 1.145 0.82
17_S 29_V 1.143 0.82
159_L 163_K 1.141 0.82
50_N 53_I 1.14 0.82
50_N 68_T 1.14 0.82
15_T 19_L 1.138 0.81
19_L 81_I 1.135 0.81
59_M 64_V 1.13 0.81
303_S 313_S 1.124 0.80
80_G 338_G 1.122 0.80
300_S 304_V 1.11 0.79
335_V 339_V 1.108 0.79
394_M 407_L 1.094 0.78
205_H 326_V 1.086 0.77
188_L 218_C 1.086 0.77
48_F 354_V 1.084 0.77
413_C 425_L 1.081 0.77
43_M 317_Y 1.075 0.76
390_I 407_L 1.074 0.76
123_V 304_V 1.072 0.76
151_S 374_L 1.07 0.75
126_F 297_Y 1.069 0.75
129_T 297_Y 1.065 0.75
416_K 421_R 1.065 0.75
285_G 288_K 1.063 0.75
100_A 105_G 1.056 0.74
85_L 295_A 1.042 0.73
128_L 262_M 1.036 0.72
158_A 389_F 1.034 0.72
216_S 353_I 1.029 0.71
104_V 108_G 1.026 0.71
219_G 225_V 1.022 0.71
149_I 263_L 1.021 0.71
119_F 307_A 1.015 0.70
135_Y 293_N 1.013 0.70
87_V 282_L 1.01 0.69
25_H 291_N 1.008 0.69
265_N 303_S 1.004 0.69
31_T 205_H 1.004 0.69
72_A 76_S 1.003 0.69
102_V 106_A 1.001 0.68
201_S 382_F 1 0.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3qe7A10.86261000.674Contact Map0.402
3o7qA10.434750.986Contact Map0.434
2gfpA20.43694.70.986Contact Map0.139
1t7sA20.10362.50.988Contact Map0.328
2l9uA20.08332.30.988Contact Map0.032
2k3cA10.06982.30.988Contact Map0
2ls3A10.06311.90.989Contact Map1
4g75A10.13741.70.989Contact Map0.242
4j05A20.49551.60.989Contact Map0.422
1gu9A120.20271.50.989Contact Map0.461
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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