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OPENSEQ.org
YDEH - Diguanylate cyclase YdeH
UniProt: P31129 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11643
Length: 296 (278)
Sequences: 389
Seq/Len: 1.40
YDEH
Paralog alert: 0.44 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ADRA YDAM YDEH YEAP YFIN YNEF
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
197_R 200_E 3.154 1.00
143_L 211_I 2.304 0.99
209_E 270_D 2.095 0.98
206_G 209_E 1.966 0.97
173_N 181_G 1.847 0.96
205_Y 266_I 1.834 0.96
170_K 174_D 1.797 0.95
162_M 226_G 1.776 0.94
170_K 274_Y 1.772 0.94
178_H 270_D 1.754 0.94
178_H 207_G 1.74 0.94
206_G 270_D 1.705 0.93
207_G 274_Y 1.673 0.92
174_D 270_D 1.671 0.92
145_E 201_T 1.638 0.91
140_R 170_K 1.599 0.89
191_Y 237_A 1.593 0.89
134_L 165_D 1.592 0.89
165_D 274_Y 1.586 0.89
170_K 207_G 1.571 0.88
62_G 65_D 1.534 0.86
146_S 203_Y 1.524 0.86
174_D 274_Y 1.519 0.86
142_V 201_T 1.494 0.84
174_D 207_G 1.474 0.83
227_V 230_C 1.472 0.83
165_D 173_N 1.468 0.83
174_D 181_G 1.458 0.82
214_V 225_A 1.445 0.82
170_K 209_E 1.433 0.81
214_V 222_A 1.428 0.81
174_D 178_H 1.407 0.79
209_E 274_Y 1.403 0.79
174_D 277_K 1.402 0.79
178_H 209_E 1.398 0.79
270_D 274_Y 1.367 0.76
250_T 276_G 1.362 0.76
207_G 270_D 1.35 0.75
173_N 207_G 1.341 0.74
27_V 36_R 1.33 0.74
173_N 277_K 1.329 0.74
174_D 200_E 1.327 0.73
174_D 209_E 1.322 0.73
181_G 209_E 1.32 0.73
138_P 191_Y 1.313 0.72
138_P 142_V 1.313 0.72
265_V 286_F 1.306 0.72
65_D 98_W 1.304 0.72
131_M 138_P 1.303 0.71
184_V 208_E 1.297 0.71
170_K 270_D 1.293 0.71
57_W 62_G 1.28 0.69
170_K 178_H 1.279 0.69
94_V 98_W 1.278 0.69
235_N 282_N 1.277 0.69
167_D 280_G 1.266 0.68
140_R 174_D 1.266 0.68
165_D 207_G 1.263 0.68
22_H 52_C 1.262 0.68
168_R 208_E 1.262 0.68
165_D 174_D 1.246 0.66
146_S 201_T 1.229 0.65
165_D 181_G 1.212 0.63
274_Y 277_K 1.207 0.63
173_N 209_E 1.205 0.63
165_D 210_F 1.205 0.63
165_D 277_K 1.194 0.62
165_D 200_E 1.19 0.61
134_L 182_D 1.189 0.61
24_Q 30_F 1.185 0.61
140_R 206_G 1.178 0.60
165_D 209_E 1.17 0.59
137_L 192_L 1.167 0.59
143_L 196_T 1.161 0.58
178_H 274_Y 1.161 0.58
163_L 201_T 1.161 0.58
208_E 230_C 1.158 0.58
172_V 236_H 1.156 0.58
134_L 181_G 1.155 0.58
173_N 178_H 1.151 0.57
41_P 45_D 1.15 0.57
135_T 277_K 1.143 0.57
162_M 251_A 1.138 0.56
178_H 277_K 1.135 0.56
140_R 274_Y 1.134 0.56
140_R 182_D 1.132 0.56
254_S 257_F 1.132 0.56
36_R 45_D 1.13 0.55
178_H 206_G 1.116 0.54
270_D 277_K 1.114 0.54
181_G 277_K 1.111 0.53
52_C 83_H 1.11 0.53
173_N 185_L 1.109 0.53
169_F 277_K 1.106 0.53
43_I 46_N 1.101 0.52
45_D 48_S 1.099 0.52
27_V 34_V 1.094 0.52
179_L 266_I 1.091 0.51
170_K 173_N 1.087 0.51
254_S 272_A 1.086 0.51
24_Q 27_V 1.085 0.51
22_H 83_H 1.082 0.50
183_V 186_R 1.078 0.50
169_F 173_N 1.075 0.50
280_G 283_R 1.074 0.50
169_F 178_H 1.072 0.49
139_G 276_G 1.072 0.49
23_Y 34_V 1.071 0.49
172_V 181_G 1.066 0.49
276_G 280_G 1.066 0.49
172_V 209_E 1.064 0.49
271_R 287_I 1.064 0.49
28_S 34_V 1.063 0.49
140_R 209_E 1.062 0.48
203_Y 287_I 1.059 0.48
196_T 207_G 1.059 0.48
173_N 270_D 1.055 0.48
133_V 211_I 1.054 0.48
26_L 31_H 1.054 0.48
174_D 197_R 1.053 0.48
42_E 45_D 1.052 0.47
185_L 202_V 1.051 0.47
226_G 251_A 1.048 0.47
22_H 25_W 1.043 0.47
165_D 270_D 1.032 0.45
147_F 228_R 1.03 0.45
29_M 41_P 1.029 0.45
165_D 170_K 1.029 0.45
248_T 282_N 1.026 0.45
147_F 250_T 1.024 0.45
134_L 207_G 1.021 0.44
173_N 182_D 1.018 0.44
253_V 264_V 1.018 0.44
175_T 274_Y 1.017 0.44
168_R 281_R 1.016 0.44
165_D 197_R 1.013 0.44
231_Q 234_D 1.012 0.43
134_L 173_N 1.012 0.43
134_L 277_K 1.009 0.43
28_S 36_R 1.009 0.43
178_H 281_R 1.008 0.43
191_Y 238_I 1.007 0.43
169_F 274_Y 1.007 0.43
22_H 79_H 1.006 0.43
23_Y 32_S 1.003 0.43
30_F 34_V 1 0.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4h54A211000.292Contact Map0.308
1w25A20.93581000.417Contact Map0.277
3hvbA20.60811000.468Contact Map
3pjxA10.61491000.486Contact Map0.219
3tvkA10.57771000.488Contact Map0.289
3ezuA10.94591000.491Contact Map0.29
3mtkA20.57431000.495Contact Map0.367
3ignA10.58781000.501Contact Map0.271
3i5cA20.65881000.51Contact Map0.277
3breA20.94931000.517Contact Map0.286
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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