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OPENSEQ.org
RNB - Exoribonuclease 2
UniProt: P30850 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11620
Length: 644 (620)
Sequences: 1684
Seq/Len: 2.72
RNB
Paralog alert: 0.28 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: RNB RNR
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
565_A 625_D 4.199 1.00
190_E 299_E 4.101 1.00
278_V 306_E 3.783 1.00
203_A 314_D 3.667 1.00
289_S 293_T 3.565 1.00
193_T 278_V 3.552 1.00
131_E 146_E 3.438 1.00
563_R 625_D 3.271 1.00
215_K 223_Q 3.206 1.00
44_Y 73_A 3.083 1.00
281_V 305_I 3.023 1.00
175_P 178_V 2.927 1.00
394_I 489_L 2.853 1.00
219_D 287_T 2.808 1.00
59_R 80_E 2.632 1.00
221_K 287_T 2.571 1.00
493_A 507_N 2.461 1.00
195_L 215_K 2.453 1.00
44_Y 62_A 2.44 1.00
355_A 358_F 2.422 1.00
227_A 283_A 2.421 1.00
197_F 305_I 2.405 1.00
47_P 50_Q 2.348 1.00
212_L 389_V 2.289 1.00
197_F 308_K 2.256 1.00
566_A 578_V 2.237 1.00
39_D 59_R 2.236 1.00
61_I 77_E 2.219 1.00
249_A 534_R 2.201 1.00
458_A 462_G 2.191 1.00
236_A 239_S 2.146 1.00
149_Q 166_A 2.144 1.00
176_D 180_T 2.144 1.00
327_Q 338_R 2.134 1.00
274_R 277_E 2.133 1.00
412_I 528_T 2.128 1.00
190_E 301_F 2.122 1.00
90_V 97_L 2.118 1.00
317_S 383_R 2.109 1.00
302_A 512_K 2.088 1.00
283_A 303_A 2.082 1.00
225_I 285_R 2.06 1.00
317_S 321_E 2.051 1.00
252_N 538_N 2.042 1.00
250_F 503_G 2.041 1.00
24_G 36_L 1.976 0.99
130_A 145_A 1.975 0.99
232_T 505_M 1.97 0.99
574_G 577_R 1.967 0.99
126_D 153_F 1.961 0.99
250_F 534_R 1.961 0.99
23_E 59_R 1.948 0.99
26_V 51_M 1.941 0.99
178_V 244_A 1.939 0.99
246_K 527_I 1.934 0.99
415_V 478_S 1.934 0.99
285_R 301_F 1.926 0.99
175_P 244_A 1.923 0.99
223_Q 285_R 1.881 0.99
275_A 307_S 1.876 0.99
576_M 589_I 1.869 0.99
102_D 127_W 1.842 0.99
23_E 61_I 1.842 0.99
287_T 297_N 1.825 0.99
574_G 588_F 1.822 0.99
369_G 373_E 1.805 0.99
415_V 482_G 1.794 0.99
427_L 431_L 1.791 0.99
27_K 37_E 1.79 0.99
204_S 365_R 1.787 0.99
213_F 227_A 1.786 0.99
208_M 310_K 1.782 0.99
349_E 353_N 1.777 0.99
109_A 112_C 1.766 0.99
36_L 46_I 1.761 0.98
225_I 283_A 1.749 0.98
367_I 378_V 1.722 0.98
596_A 601_L 1.719 0.98
255_P 545_V 1.714 0.98
565_A 623_V 1.689 0.98
288_L 395_A 1.684 0.98
283_A 301_F 1.68 0.98
226_V 286_M 1.673 0.98
355_A 359_K 1.66 0.98
568_I 618_Y 1.64 0.97
36_L 60_I 1.624 0.97
417_M 482_G 1.613 0.97
302_A 516_K 1.609 0.97
534_R 537_L 1.605 0.97
205_T 208_M 1.603 0.97
557_K 562_T 1.6 0.97
469_R 472_Q 1.598 0.97
383_R 386_N 1.593 0.97
345_Q 384_I 1.587 0.97
398_I 489_L 1.585 0.96
563_R 627_T 1.582 0.96
551_A 631_V 1.562 0.96
319_W 334_A 1.561 0.96
264_R 268_D 1.552 0.96
197_F 227_A 1.55 0.96
246_K 530_Q 1.55 0.96
227_A 303_A 1.517 0.95
503_G 531_M 1.514 0.95
197_F 281_V 1.512 0.95
320_L 338_R 1.506 0.95
214_A 339_L 1.497 0.95
610_V 613_K 1.496 0.95
341_A 345_Q 1.496 0.95
453_R 456_L 1.489 0.95
326_W 330_S 1.476 0.94
196_D 308_K 1.467 0.94
340_L 392_A 1.462 0.94
549_L 552_R 1.456 0.94
63_V 74_E 1.45 0.93
581_V 623_V 1.45 0.93
99_I 128_A 1.44 0.93
133_R 146_E 1.437 0.93
244_A 247_I 1.427 0.93
284_C 399_C 1.416 0.92
28_A 51_M 1.415 0.92
192_L 285_R 1.413 0.92
59_R 79_V 1.411 0.92
167_R 544_D 1.409 0.92
25_V 59_R 1.409 0.92
200_I 388_I 1.407 0.92
281_V 303_A 1.404 0.92
631_V 638_I 1.401 0.92
127_W 163_V 1.398 0.92
217_L 221_K 1.393 0.92
351_R 391_E 1.389 0.91
192_L 303_A 1.367 0.91
566_A 624_I 1.367 0.91
284_C 300_F 1.364 0.90
214_A 340_L 1.364 0.90
454_R 457_D 1.358 0.90
216_A 342_Q 1.352 0.90
110_I 145_A 1.346 0.90
529_V 533_E 1.338 0.89
319_W 337_V 1.325 0.89
300_F 399_C 1.321 0.88
35_F 43_S 1.318 0.88
571_I 576_M 1.316 0.88
201_D 210_D 1.315 0.88
217_L 223_Q 1.314 0.88
417_M 476_E 1.312 0.88
474_F 536_R 1.311 0.88
589_I 593_F 1.311 0.88
88_G 99_I 1.309 0.88
164_T 548_W 1.302 0.87
61_I 76_E 1.296 0.87
109_A 113_R 1.296 0.87
300_F 400_A 1.291 0.87
451_K 455_E 1.29 0.87
356_L 359_K 1.284 0.86
202_S 316_V 1.282 0.86
493_A 510_L 1.282 0.86
412_I 531_M 1.271 0.86
457_D 462_G 1.269 0.86
280_P 304_T 1.264 0.85
512_K 516_K 1.262 0.85
26_V 34_G 1.255 0.85
288_L 294_I 1.252 0.85
165_L 259_I 1.247 0.84
222_L 346_R 1.247 0.84
213_F 308_K 1.242 0.84
369_G 375_L 1.242 0.84
196_D 336_Q 1.241 0.84
250_F 538_N 1.241 0.84
131_E 148_T 1.239 0.84
62_A 73_A 1.236 0.83
568_I 576_M 1.233 0.83
198_V 311_L 1.231 0.83
317_S 386_N 1.23 0.83
212_L 340_L 1.229 0.83
36_L 62_A 1.227 0.83
373_E 552_R 1.227 0.83
62_A 75_P 1.225 0.83
530_Q 534_R 1.223 0.83
221_K 290_A 1.221 0.82
358_F 469_R 1.221 0.82
213_F 283_A 1.218 0.82
282_L 302_A 1.217 0.82
214_A 336_Q 1.216 0.82
170_L 541_A 1.214 0.82
339_L 342_Q 1.214 0.82
26_V 36_L 1.207 0.81
576_M 594_L 1.207 0.81
589_I 624_I 1.204 0.81
135_H 143_F 1.204 0.81
531_M 534_R 1.2 0.81
213_F 225_I 1.197 0.81
364_Y 584_G 1.189 0.80
619_K 622_D 1.182 0.80
198_V 336_Q 1.18 0.79
286_M 399_C 1.18 0.79
98_A 109_A 1.176 0.79
249_A 531_M 1.175 0.79
311_L 333_I 1.174 0.79
103_H 167_R 1.17 0.79
239_S 243_K 1.169 0.78
25_V 37_E 1.168 0.78
61_I 79_V 1.167 0.78
585_A 638_I 1.164 0.78
197_F 212_L 1.16 0.78
287_T 296_D 1.148 0.77
129_V 149_Q 1.145 0.76
477_I 494_T 1.14 0.76
101_P 105_L 1.139 0.76
276_N 306_E 1.137 0.76
197_F 213_F 1.136 0.76
54_V 75_P 1.129 0.75
348_G 352_H 1.126 0.75
217_L 287_T 1.125 0.75
348_G 387_R 1.123 0.74
223_Q 287_T 1.122 0.74
128_A 147_L 1.122 0.74
251_T 258_N 1.121 0.74
170_L 259_I 1.118 0.74
367_I 376_D 1.116 0.74
452_L 456_L 1.113 0.74
171_E 537_L 1.109 0.73
311_L 337_V 1.104 0.73
85_R 131_E 1.099 0.72
36_L 73_A 1.099 0.72
123_K 126_D 1.096 0.72
341_A 344_C 1.096 0.72
298_I 399_C 1.093 0.72
510_L 514_V 1.091 0.71
507_N 511_L 1.09 0.71
595_H 601_L 1.089 0.71
203_A 315_Q 1.088 0.71
311_L 319_W 1.087 0.71
293_T 350_W 1.086 0.71
21_R 61_I 1.084 0.71
551_A 638_I 1.078 0.70
309_A 329_E 1.075 0.70
112_C 122_F 1.074 0.70
198_V 337_V 1.071 0.69
202_S 312_V 1.07 0.69
160_P 549_L 1.068 0.69
631_V 634_E 1.066 0.69
278_V 304_T 1.065 0.69
77_E 103_H 1.063 0.69
219_D 296_D 1.062 0.68
601_L 616_T 1.061 0.68
99_I 130_A 1.059 0.68
45_F 48_P 1.057 0.68
209_D 253_Y 1.056 0.68
415_V 476_E 1.056 0.68
75_P 78_L 1.056 0.68
341_A 384_I 1.054 0.68
221_K 296_D 1.053 0.68
122_F 147_L 1.05 0.67
272_S 499_I 1.05 0.67
83_L 135_H 1.05 0.67
252_N 541_A 1.048 0.67
38_V 41_Q 1.047 0.67
289_S 296_D 1.046 0.67
428_A 438_V 1.046 0.67
393_M 416_H 1.046 0.67
412_I 506_I 1.044 0.67
34_G 51_M 1.043 0.66
34_G 75_P 1.043 0.66
401_A 507_N 1.041 0.66
193_T 304_T 1.04 0.66
99_I 145_A 1.039 0.66
596_A 616_T 1.038 0.66
99_I 147_L 1.037 0.66
344_C 391_E 1.037 0.66
168_H 544_D 1.036 0.66
60_I 75_P 1.035 0.66
328_P 331_E 1.034 0.65
227_A 285_R 1.032 0.65
269_D 274_R 1.03 0.65
282_L 511_L 1.03 0.65
251_T 260_P 1.03 0.65
93_K 96_R 1.026 0.65
210_D 253_Y 1.026 0.65
402_R 406_D 1.025 0.64
576_M 624_I 1.021 0.64
242_D 509_R 1.021 0.64
405_R 491_A 1.019 0.64
210_D 261_M 1.019 0.64
403_V 515_I 1.018 0.64
46_I 60_I 1.018 0.64
241_L 571_I 1.018 0.64
62_A 132_M 1.015 0.63
224_L 288_L 1.015 0.63
506_I 568_I 1.015 0.63
575_G 587_A 1.009 0.63
282_L 512_K 1.008 0.63
315_Q 326_W 1.007 0.62
604_S 607_N 1.003 0.62
153_F 156_D 1.002 0.62
359_K 469_R 1 0.62
488_G 554_L 1 0.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2id0A40.99381000.091Contact Map0.72
2vnuD10.9721000.166Contact Map0.697
4ifdJ10.9721000.168Contact Map0.663
2r7dA30.69411000.431Contact Map0.653
3bzcA10.796699.90.882Contact Map0.449
1go3E20.239199.70.909Contact Map0.642
1e3pA10.807599.60.914Contact Map0.174
4aybE10.239199.50.921Contact Map0.562
2ckzB20.23699.50.922Contact Map0.539
1luzA20.125899.40.926Contact Map0.596
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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