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OPENSEQ.org
MOAA - Cyclic pyranopterin monophosphate synthase
UniProt: P30745 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11595
Length: 329 (325)
Sequences: 2837
Seq/Len: 8.73
MOAA
Paralog alert: 0.49 [within 20: 0.01] - ratio of genomes with paralogs
Cluster includes: ASLB MOAA YDEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
26_F 103_Y 4.627 1.00
129_A 142_N 4.466 1.00
149_D 184_R 3.717 1.00
110_A 114_D 3.138 1.00
65_E 94_R 3.019 1.00
53_R 86_A 2.802 1.00
106_E 146_A 2.522 1.00
150_A 154_A 2.406 1.00
141_F 145_M 2.403 1.00
61_R 297_E 2.372 1.00
122_V 148_I 2.355 1.00
292_Q 295_A 2.34 1.00
168_D 171_H 2.34 1.00
54_R 293_Q 2.309 1.00
163_T 177_F 2.244 1.00
286_L 299_R 2.243 1.00
131_Q 172_H 2.204 1.00
56_T 67_V 2.162 1.00
282_N 285_D 2.16 1.00
108_D 111_S 2.152 1.00
88_R 118_T 2.15 1.00
133_H 139_D 2.135 1.00
82_D 85_A 2.132 1.00
150_A 153_E 2.091 1.00
60_A 93_I 2.056 1.00
129_A 139_D 2.007 1.00
270_K 282_N 2.001 1.00
30_Y 125_D 1.893 1.00
48_T 51_E 1.89 1.00
161_V 181_I 1.884 1.00
79_D 82_D 1.864 1.00
81_T 111_S 1.837 1.00
149_D 152_F 1.835 1.00
214_R 248_L 1.819 1.00
110_A 154_A 1.799 1.00
131_Q 173_Q 1.799 1.00
109_V 147_G 1.798 1.00
167_R 212_V 1.792 1.00
81_T 108_D 1.783 1.00
69_L 84_I 1.781 1.00
56_T 87_V 1.776 1.00
60_A 90_N 1.762 1.00
128_D 131_Q 1.754 1.00
57_R 86_A 1.726 1.00
69_L 87_V 1.72 1.00
142_N 146_A 1.707 1.00
18_L 265_V 1.701 1.00
297_E 301_S 1.677 1.00
109_V 150_A 1.672 1.00
49_V 83_I 1.659 1.00
128_D 176_T 1.653 1.00
152_F 159_V 1.652 1.00
49_V 79_D 1.637 1.00
113_R 156_F 1.608 1.00
111_S 114_D 1.603 1.00
59_F 300_I 1.577 1.00
124_V 161_V 1.568 1.00
146_A 149_D 1.566 1.00
122_V 147_G 1.553 1.00
25_N 104_R 1.55 1.00
128_D 173_Q 1.534 1.00
51_E 288_E 1.523 1.00
52_I 83_I 1.513 1.00
143_Q 146_A 1.501 1.00
302_A 306_E 1.498 1.00
132_F 144_V 1.483 1.00
215_D 219_R 1.479 1.00
173_Q 176_T 1.478 1.00
225_Q 238_C 1.462 1.00
161_V 186_I 1.461 1.00
20_I 80_F 1.458 0.99
84_I 117_L 1.45 0.99
109_V 154_A 1.439 0.99
54_R 58_A 1.431 0.99
214_R 218_L 1.43 0.99
47_L 284_R 1.43 0.99
88_R 96_I 1.412 0.99
85_A 114_D 1.407 0.99
179_N 183_H 1.403 0.99
47_L 51_E 1.397 0.99
149_D 153_E 1.386 0.99
298_A 302_A 1.38 0.99
120_I 156_F 1.377 0.99
210_G 250_M 1.371 0.99
16_L 59_F 1.367 0.99
49_V 82_D 1.36 0.99
131_Q 134_A 1.356 0.99
14_Y 65_E 1.342 0.99
148_I 186_I 1.332 0.99
53_R 57_R 1.332 0.99
127_L 173_Q 1.317 0.99
187_Q 245_E 1.306 0.99
79_D 83_I 1.297 0.99
75_S 98_V 1.294 0.99
315_Q 318_T 1.287 0.98
152_F 186_I 1.273 0.98
113_R 118_T 1.258 0.98
257_C 260_C 1.258 0.98
85_A 111_S 1.256 0.98
179_N 220_R 1.256 0.98
126_S 131_Q 1.248 0.98
109_V 113_R 1.244 0.98
100_T 122_V 1.241 0.98
128_D 172_H 1.225 0.98
50_D 86_A 1.223 0.98
145_M 149_D 1.222 0.98
147_G 150_A 1.221 0.98
140_K 143_Q 1.215 0.98
113_R 154_A 1.204 0.97
16_L 265_V 1.198 0.97
18_L 52_I 1.194 0.97
95_Q 119_G 1.19 0.97
53_R 89_E 1.189 0.97
99_T 121_N 1.188 0.97
133_H 140_K 1.182 0.97
75_S 104_R 1.18 0.97
179_N 182_Q 1.178 0.97
85_A 89_E 1.173 0.97
317_N 320_I 1.173 0.97
86_A 89_E 1.173 0.97
7_D 11_R 1.152 0.96
26_F 132_F 1.138 0.96
216_E 219_R 1.125 0.96
58_A 296_L 1.118 0.95
55_V 265_V 1.116 0.95
307_K 311_H 1.114 0.95
124_V 148_I 1.099 0.95
175_D 219_R 1.098 0.95
105_L 147_G 1.096 0.95
25_N 101_N 1.093 0.95
312_F 315_Q 1.091 0.95
110_A 113_R 1.083 0.94
102_G 148_I 1.082 0.94
129_A 133_H 1.077 0.94
87_V 96_I 1.072 0.94
121_N 162_N 1.072 0.94
62_L 301_S 1.053 0.93
176_T 179_N 1.052 0.93
152_F 184_R 1.04 0.93
62_L 297_E 1.039 0.92
88_R 115_A 1.029 0.92
134_A 169_V 1.025 0.92
298_A 301_S 1.022 0.92
291_T 295_A 1.016 0.91
266_S 272_H 1.016 0.91
141_F 180_W 1.013 0.91
145_M 180_W 1.013 0.91
301_S 305_R 1.009 0.91
130_R 134_A 1.007 0.91
290_D 295_A 1.004 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1tv8A20.98781000.275Contact Map0.803
4k36A20.93311000.402Contact Map0.694
4m7tA10.72951000.57Contact Map0.587
3c8fA10.66871000.6Contact Map0.686
2a5hA40.8451000.602Contact Map0.481
2yx0A10.7661000.631Contact Map0.63
3rfaA20.826799.90.654Contact Map0.536
2z2uA10.732599.90.655Contact Map0.638
2qgqA80.857199.90.657Contact Map0.681
3iixA10.908899.90.669Contact Map0.618
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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