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OPENSEQ.org
APPB - Cytochrome bd-II oxidase subunit 2
UniProt: P26458 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11379
Length: 378 (361)
Sequences: 1319
Seq/Len: 3.65
APPB
Paralog alert: 0.48 [within 20: 0.00] - ratio of genomes with paralogs
Cluster includes: APPB CYDB
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
166_T 169_P 3.169 1.00
34_C 181_I 2.905 1.00
267_F 307_I 2.831 1.00
343_V 347_L 2.691 1.00
86_F 145_V 2.336 1.00
359_Y 362_W 2.242 1.00
48_I 365_M 2.23 1.00
274_C 296_L 2.19 1.00
170_L 174_L 2.161 1.00
45_E 199_R 2.15 1.00
128_L 177_L 2.128 1.00
333_Q 337_S 2.066 1.00
58_E 105_D 1.996 1.00
19_L 71_L 1.993 1.00
131_P 176_S 1.992 1.00
74_A 339_M 1.954 1.00
34_C 177_L 1.923 1.00
131_P 180_V 1.921 1.00
312_F 325_T 1.914 1.00
47_R 51_N 1.907 1.00
185_G 204_T 1.894 1.00
352_L 355_L 1.863 1.00
225_G 228_G 1.85 1.00
17_V 21_V 1.846 1.00
132_V 173_G 1.839 0.99
204_T 282_I 1.837 0.99
24_I 295_S 1.828 0.99
174_L 178_G 1.792 0.99
227_D 230_V 1.791 0.99
341_V 345_I 1.789 0.99
178_G 214_C 1.771 0.99
186_V 204_T 1.761 0.99
85_G 145_V 1.745 0.99
275_P 297_M 1.739 0.99
205_K 283_Y 1.712 0.99
132_V 177_L 1.709 0.99
183_Q 295_S 1.7 0.99
50_I 104_F 1.697 0.99
46_R 120_D 1.696 0.99
33_G 127_S 1.687 0.99
228_G 231_L 1.654 0.99
139_G 172_C 1.635 0.99
193_V 366_T 1.634 0.99
226_I 229_F 1.632 0.99
8_R 330_T 1.62 0.98
136_I 173_G 1.605 0.98
8_R 336_L 1.576 0.98
174_L 214_C 1.558 0.98
143_L 166_T 1.554 0.98
133_V 165_L 1.548 0.98
142_L 309_L 1.544 0.98
92_L 133_V 1.537 0.98
202_L 206_R 1.531 0.97
267_F 270_L 1.523 0.97
317_S 320_P 1.502 0.97
272_F 276_L 1.482 0.97
86_F 140_N 1.481 0.97
85_G 89_A 1.461 0.96
122_G 126_G 1.457 0.96
158_L 320_P 1.455 0.96
107_R 120_D 1.446 0.96
86_F 89_A 1.445 0.96
43_D 116_R 1.44 0.96
81_A 314_M 1.434 0.96
28_F 358_Y 1.414 0.95
134_F 180_V 1.408 0.95
93_V 134_F 1.406 0.95
132_V 136_I 1.4 0.95
13_L 17_V 1.397 0.95
104_F 119_W 1.377 0.95
233_A 237_N 1.377 0.95
121_A 125_I 1.364 0.94
181_I 207_A 1.363 0.94
28_F 56_H 1.361 0.94
216_L 272_F 1.347 0.94
227_D 231_L 1.344 0.94
14_L 343_V 1.342 0.93
140_N 164_L 1.335 0.93
40_A 49_V 1.335 0.93
340_L 344_L 1.325 0.93
8_R 240_S 1.324 0.93
179_M 301_V 1.307 0.92
18_I 21_V 1.303 0.92
49_V 188_L 1.297 0.92
212_M 272_F 1.296 0.92
225_G 230_V 1.296 0.92
108_G 116_R 1.296 0.92
340_L 364_R 1.289 0.92
124_V 128_L 1.288 0.92
126_G 130_P 1.288 0.92
226_I 231_L 1.287 0.92
346_F 349_I 1.277 0.91
201_Q 205_K 1.268 0.91
90_M 137_A 1.266 0.91
312_F 322_S 1.262 0.90
140_N 169_P 1.259 0.90
32_I 49_V 1.247 0.90
133_V 136_I 1.245 0.90
11_W 339_M 1.236 0.89
28_F 191_K 1.233 0.89
226_I 230_V 1.23 0.89
96_S 126_G 1.229 0.89
267_F 300_G 1.222 0.88
70_A 73_A 1.216 0.88
145_V 314_M 1.215 0.88
30_M 131_P 1.208 0.88
96_S 129_V 1.205 0.88
18_I 66_L 1.204 0.87
20_V 302_I 1.194 0.87
47_R 50_I 1.191 0.87
125_I 129_V 1.189 0.87
215_F 304_T 1.188 0.86
48_I 51_N 1.186 0.86
273_F 277_L 1.182 0.86
101_P 104_F 1.168 0.85
225_G 229_F 1.165 0.85
34_C 127_S 1.163 0.85
246_L 249_V 1.161 0.85
28_F 291_F 1.156 0.84
164_L 167_P 1.152 0.84
128_L 132_V 1.15 0.84
299_F 303_F 1.145 0.84
35_L 185_G 1.14 0.83
355_L 359_Y 1.139 0.83
150_T 158_L 1.137 0.83
117_K 121_A 1.129 0.82
289_W 293_M 1.129 0.82
17_V 69_G 1.123 0.82
78_V 313_V 1.12 0.82
48_I 196_I 1.115 0.81
178_G 207_A 1.113 0.81
230_V 233_A 1.113 0.81
160_S 163_Q 1.107 0.81
118_M 121_A 1.099 0.80
89_A 164_L 1.099 0.80
10_I 340_L 1.099 0.80
20_V 299_F 1.094 0.80
89_A 136_I 1.09 0.79
11_W 74_A 1.09 0.79
99_F 122_G 1.087 0.79
128_L 181_I 1.084 0.79
148_A 158_L 1.083 0.79
17_V 347_L 1.082 0.79
78_V 82_A 1.08 0.78
43_D 108_G 1.077 0.78
15_I 70_A 1.072 0.78
69_G 347_L 1.069 0.77
276_L 280_M 1.067 0.77
347_L 351_L 1.067 0.77
270_L 300_G 1.066 0.77
189_Q 282_I 1.065 0.77
116_R 120_D 1.063 0.77
10_I 14_L 1.06 0.77
213_L 217_L 1.057 0.76
269_L 273_F 1.057 0.76
224_V 227_D 1.056 0.76
203_A 206_R 1.055 0.76
350_V 355_L 1.055 0.76
169_P 172_C 1.054 0.76
47_R 108_G 1.051 0.76
208_A 279_V 1.05 0.76
121_A 124_V 1.047 0.75
132_V 170_L 1.044 0.75
277_L 293_M 1.041 0.75
225_G 231_L 1.041 0.75
254_W 308_T 1.041 0.75
73_A 84_S 1.036 0.74
37_P 124_V 1.035 0.74
15_I 78_V 1.031 0.74
236_A 239_P 1.03 0.74
136_I 170_L 1.027 0.73
168_F 241_N 1.026 0.73
98_F 330_T 1.025 0.73
68_G 79_Y 1.021 0.73
198_L 285_G 1.018 0.72
179_M 298_Q 1.017 0.72
23_M 354_T 1.01 0.72
39_V 196_I 1.007 0.71
109_K 354_T 1.005 0.71
197_H 287_P 1.004 0.71
67_A 340_L 1.004 0.71
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results:
PDB Chains Cov P(%) HHΔ   Acc
3hb3B10.2467.20.978Contact Map0.438
2kncA10.14295.90.979Contact Map0.571
2gsmB20.17463.90.981Contact Map0.408
2m67A10.2092.40.983Contact Map0.48
1fftB20.21692.40.983Contact Map0.132
3qe7A10.1642.30.983Contact Map0.195
2m20A20.12172.10.983Contact Map0.546
4hg6A10.3731.90.984Contact Map0.282
2yevB20.19311.80.984Contact Map0.459
1v54B20.15341.80.984Contact Map0.597
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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